I-Agranulocytosis

Amaseli egazi amhlophe alwa nezifo ezivela kubhaktheriya, amagciwane, isikhunta namanye amagciwane. Uhlobo olulodwa olubalulekile lwengqamuzana yegazi elimhlophe yi-granulocyte, eyenziwe emnkantsheni wethambo futhi ihamba egazini umzimba wonke. Ama-granulocyte aqonda ukutheleleka, abuthana ezindaweni zokutheleleka, abhubhise amagciwane.

Lapho umzimba unama-granulocyte ambalwa kakhulu, isimo sibizwa ngokuthi i-agranulocytosis. Lokhu kwenza kube nzima emzimbeni ukulwa namagciwane. Ngenxa yalokho, lo muntu kungenzeka agule kakhulu ezifweni.

I-Agranulocytosis ingabangelwa ngu:

• Ukuphazamiseka okuzenzakalelayo
• Izifo zomnkantsha wamathambo, njenge-myelodysplasia noma i-leukemia enkulu ye-granular lymphocyte (LGL)
• Imithi ethile esetshenziselwa ukwelapha izifo, kubandakanya umdlavuza
• Izidakamizwa ezithile zasemgwaqweni
• Ukungondleki kahle
• Ukulungiselela ukufakelwa umnkantsha wethambo
• Inkinga ngezakhi zofuzo

Izimpawu zalesi simo zingafaka:

• Imfiva
• Amakhaza
• UMalaise
• Ubuthakathaka obujwayelekile
• Umphimbo obuhlungu
• Izilonda zomlomo nezomphimbo
• Ubuhlungu bamathambo
• Inyumoniya
• Ukushaqeka

Kuzokwenziwa ukuhlolwa kokwehlukaniswa kwegazi ukukala iphesenti lohlobo ngalunye lwamaseli amhlophe egazi egazini lakho.

Olunye uvivinyo lokuthola lesi simo lungafaka:

• I-bone marrow biopsy
• Isilonda somlomo sesilonda
• Izifundo ze-neutrophil antibody (ukuhlolwa kwegazi)

Ukwelashwa kuya ngesizathu sokubalwa kwamaseli egazi amhlophe aphansi. Isibonelo, uma umuthi uyimbangela, ukuyeka noma ukushintshela komunye umuthi kungasiza. Kwezinye izimo, kuzosetshenziswa imithi yokusiza umzimba ekwenzeni amangqamuzana amhlophe egazi amaningi.

Ukwelapha noma ukususa imbangela kuvame ukuletha imiphumela emihle.

Uma uthola ukwelashwa noma uthatha umuthi ongadala i-agranulocytosis, umhlinzeki wakho wokunakekelwa kwezempilo uzosebenzisa ukuhlolwa kwegazi ukukuqapha.

IGranulocytopenia; IGranulopenia

• Amaseli egazi

Ukupheka JR. Ama-syndromes okwehluleka komnkantsha wamathambo. Ku: Hsi ED, ed. I-Hematopathology. 3rd ed. IPhiladelphia, PA: Elsevier; 2018: isahluko 5.

IKlokkevold PR, uMealey BL. Ithonya lezimo zesistimu. Ku: Newman MG, Takei HH, Klokkevold PR, Carranza FA, eds. I-Clinical Periodontology kaNewman noCarranza. Umhlaka 13. IPhiladelphia, PA: Elsevier; 2019: isahluko 14.

USive J, Foggo V. Isifo se-Haematological. Ku: Uphaphe A, uRandall D, iWaterhouse M, ama-eds. I-Kumar and Clarke's Clinical Medicine. Umhlaka 10. IPhiladelphia, PA: Elsevier; 2021: isahluko 17.