Ukushoda kwe-fibrinogen engokwemvelo

Ukushoda kwe-fibrinogen ye-Congenital kuyisifo esingajwayelekile kakhulu, esizuzwe njengefa lapho igazi lingagcwali ngokwejwayelekile. Ithinta iphrotheni ebizwa nge-fibrinogen. Le phrotheni iyadingeka ukuze igazi lijiye.

Lesi sifo singenxa yezakhi zofuzo ezingavamile. I-Fibrinogen iyathinteka kuye ngokuthi izakhi zofuzo zitholwa kanjani:

• Lapho isakhi esingajwayelekile sidluliselwa kubazali bobabili, umuntu uzoba nokuntuleka okuphelele kwe-fibrinogen (afibrinogenemia).
• Lapho isakhi esingajwayelekile sidluliswa sisuka kumzali oyedwa, umuntu uzoba nezinga elincishisiwe le-fibrinogen (hypofibrinogenemia) noma abe nenkinga yokusebenza kwe-fibrinogen (dysfibrinogenemia). Kwesinye isikhathi, lezi zinkinga ezimbili ze-fibrinogen zingenzeka kumuntu ofanayo.

Abantu abanenkinga ephelele ye-fibrinogen bangaba nalezi zimpawu ezilandelayo zokopha:

• Ukulimaza kalula
• Ukopha kusuka enkabeni yesibindi ngemuva nje kokuzalwa
• Ukopha ezinhlakeni zomlomo
• Ukopha ebuchosheni (kuyaqabukela kakhulu)
• Ukopha emalungeni
• Ukopha kakhulu ngemuva kokulimala noma ukuhlinzwa
• Ukopha okungapheli kalula

Abantu abanezinga elincishisiwe le-fibrinogen bopha kancane futhi ukopha akunamandla kangako. Labo abanenkinga yokusebenza kwe-fibrinogen kaningi abanazo izimpawu.

Uma umhlinzeki wakho wezokunakekelwa kwempilo esola le nkinga, uzoba nokuhlolwa kwelabhu ukuqinisekisa uhlobo nobukhulu besifo.

Izivivinyo zifaka:

• Isikhathi sokopha
• Ukuhlolwa kwe-Fibrinogen nesikhathi sokubuyisa kabusha ukuhlola izinga nekhwalithi ye-fibrin
• Isikhathi esithile se-thromboplastin (PTT)
• Isikhathi se-Prothrombin (PT)
• Isikhathi se-Thrombin

Izindlela zokwelapha ezilandelayo zingasetshenziselwa iziqephu zokopha noma ukulungiselela ukuhlinzwa:

• I-Cryoprecipitate (umkhiqizo wegazi oqukethe i-fibrinogen egxilile nezinye izinto ezijiyisayo)
• I-Fibrinogen (RiaSTAP)
• I-Plasma (ingxenye engamanzi yegazi equkethe izinto ezijiyisayo)

Abantu abanalesi simo kufanele bathole umuthi wokugomela i-hepatitis B. Ukuba nokumpontshelwa okuningi kuphakamisa amathuba akho okuthola i-hepatitis.

Ukopha ngokweqile kuvamile ngalesi simo. Lezi ziqephu zingaba nzima, noma zibulale. Ukopha ebuchosheni kuyimbangela ehamba phambili yokufa kubantu abanalesi sifo.

Izinkinga zingafaka:

• Amahlule egazi ngokwelashwa
• Ukuthuthukiswa kwama-antibodies (inhibitors) ku-fibrinogen ngokwelashwa
• Ukopha emathunjini
• Ukuphuphuma kwesisu
• Ukudwengulwa kobende
• Ukuphulukiswa kancane kwamanxeba

Shayela umhlinzeki wakho noma ufune usizo oluphuthumayo uma wopha ngokweqile.

Tshela udokotela wakho ohlinzayo ngaphambi kokuhlinzwa uma wazi noma usola ukuthi unenkinga yokopha.

Lesi yisimo esizuzwe njengefa. Akukho ukuvimbela okwaziwayo.

I-Afibrinogenemia; I-Hypofibrinogenemia; I-Dysfibrinogenemia; Ukuntuleka kwe-Factor I

UGailani D, Wheeler AP, Neff AT. Ukukhubazeka okujwayelekile kwe-coagulation factor. Ku: Hoffman R, Benz EJ, Silberstein LE, et al, ama-eds. I-Hematology: Izimiso Eziyisisekelo Nokuzijwayeza. Umhla wesi-7. IPhiladelphia, PA: Elsevier; 2018: isahluko 137.

I-Ragni MV. Ukuphazamiseka kokopha: ukuswela kwe-coagulation factor. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-25. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 174.