I-Choriocarcinoma

I-Choriocarcinoma ngumdlavuza okhula ngokushesha owenzeka esibelethweni sowesifazane (esibelethweni). Amaseli angajwayelekile aqala ezicutshini obekungaba yi-placenta. Lesi isitho esikhula ngesikhathi sokukhulelwa ukondla umbungu.

I-Choriocarcinoma uhlobo lwesifo se-gestational trophoblastic disease.

I-Choriocarcinoma ngumdlavuza ongajwayelekile owenzeka njengokukhulelwa okungajwayelekile. Ingane ingakhula noma ingakhuli kulolu hlobo lokukhulelwa.

Umdlavuza kungenzeka futhi ngemuva kokukhulelwa okujwayelekile. Kepha kuvame ukwenzeka ngemvukuzane ephelele ye-hydatidiform. Lokhu ukukhula okwenzeka ngaphakathi esibelethweni ekuqaleni kokukhulelwa. Izicubu ezingajwayelekile ezivela emvukuzaneni zingaqhubeka zikhule noma sekuzanywe ukususwa, futhi zingaba nomdlavuza. Cishe ingxenye eyodwa yabo bonke abesifazane abane-choriocarcinoma babenemvukuzane ye-hydatidiform, noma ukukhulelwa kwe-molar.

I-Choriocarcinomas nayo ingenzeka ngemuva kokukhulelwa kwangaphambi kwesikhathi okungaqhubeki (ukukhulelwa kwesisu). Kungenzeka futhi ngemuva kokukhulelwa kwe-ectopic noma isimila sangasese.

Uphawu olungaba khona ukopha okungavamile noma okungajwayelekile kwesitho sowesifazane sowesifazane osanda kuba nemvukuzane ye-hydatidiform noma ukukhulelwa.

Ezinye izimpawu zingafaka:

• Ukopha okungafanele kwesitho sangasese sowesifazane
• Ubuhlungu, obungahlotshaniswa nokopha, noma ngenxa yokwandiswa kwama-ovari okuvame ukwenzeka nge-choriocarcinoma

Ukuhlolwa kokukhulelwa kuzoba ne-positive, noma ngabe ungakhulelwe. Izinga lokukhulelwa (HCG) lizobe liphakeme.

Ukuhlolwa kwe-pelvic kungathola isibeletho esandisiwe nama-ovari.

Ukuhlolwa kwegazi okungenziwa kufaka phakathi:

• I-serum yokulinganisa i-HCG
• Qedela ukubalwa kwegazi
• Ukuhlolwa kokusebenza kwezinso
• Ukuhlolwa kokusebenza kwesibindi

Ukuhlola ukuhlolwa okungenziwa kufaka phakathi:

• Iskena se-CT
• I-MRI
• I-pelvic ultrasound
• I-x-ray yesifuba

Kufanele ubhekwe ngokucophelela ngemuva kwemvukuzane ye-hydatidiform noma ekupheleni kokukhulelwa. Ukuxilongwa kwasekuqaleni kwe-choriocarcinoma kungathuthukisa umphumela.

Ngemuva kokutholakala kwakho, kuzokwenziwa umlando nokuhlolwa ngokucophelela ukuqinisekisa ukuthi umdlavuza awusabalalanga kwezinye izitho. I-Chemotherapy yilona hlobo oluphambili lokwelashwa.

I-Hysterectomy ukususa isisu nokwelashwa ngemisebe ayidingeki kakhulu.

Unganciphisa ukucindezela kokugula ngokujoyina iqembu lokusekela umdlavuza. Ukwabelana nabanye abanokuhlangenwe nakho okuvamile nezinkinga kungakusiza ungazizwa uwedwa.

Abesifazane abaningi umdlavuza wabo ongakasabalali bayelapheka futhi basazokwazi ukuthola izingane. I-choriocarcinoma ingabuya zingakapheli izinyanga ezimbalwa iye eminyakeni emi-3 ngemuva kokwelashwa.

Isimo kunzima ukuselapha uma umdlavuza ususakazekile futhi kwenzeka okukodwa noma okuningi kokulandelayo:

• Izifo zisakazekela esibindi noma ebuchosheni
• Izinga le-hormone yokukhulelwa (HCG) liphakeme kune-40,000 mIU / mL lapho kuqala ukwelashwa
• Umdlavuza ubuya ngemuva kokwelashwa ngamakhemikhali
• Izimpawu noma ukukhulelwa kwenzeke ngaphezu kwezinyanga ezi-4 ngaphambi kokuba ukwelashwa kuqale
• I-Choriocarcinoma yenzeka ngemuva kokukhulelwa okwaholela ekuzalweni kwengane

Abesifazane abaningi (cishe ama-70%) abanombono omubi ekuqaleni baya ekuxolelweni (isimo esingenazifo).

Shayela i-aphoyintimenti nomhlinzeki wakho wezokunakekelwa kwempilo uma uba nezimpawu kungakapheli unyaka owodwa ngemuva kwemvukuzane ye-hydatidiform noma ukukhulelwa.

Chorioblastoma; Isimila se-trophoblastic; Chorioepithelioma; I-neoplasia yokukhulelwa kwesisu; Umdlavuza - choriocarcinoma

Iwebhusayithi yeNational Cancer Institute. Ukwelashwa kwezifo ze-Gestational trophoblastic (PDQ) - inguqulo yezobuchwepheshe yezempilo. www.cancer.gov/cancertopics/pdq/treatment/gestationaltrophoblastic/HealthProfessional. Kubuyekezwe uDisemba 17, 2019. Kufinyelelwe ngoJuni 25, 2020.

USalani R, uBixel K, uCopeland LJ. Izifo ezimbi nokukhulelwa. Ku: Landon MB, Galan HL, Jauniaux ERM, et al, ama-eds. Ama-Obstetrics kaGabbe: Ukukhulelwa Okujwayelekile Nenkinga. Umhla wesi-7. IPhiladelphia, PA: Elsevier; 2021: isahluko 55.