I-Ivacaftor

-Delile

• Ngaphambi kokuthatha i-ivacaftor,
• I-Ivacaftor ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Ivacaftor isetshenziselwa ukwelapha izinhlobo ezithile ze-cystic fibrosis (isifo esizalwa naso esidala izinkinga ngokuphefumula, ukugaya ukudla, nokuzala) kubantu abadala nezingane ezinezinyanga ezine ubudala nangaphezulu. I-Ivacaftor kufanele isetshenziswe kuphela kubantu abanokwakheka okuthile kofuzo. Udokotela wakho angalawula ukuhlolwa kwegazi ukusiza ukunquma ukuthi le mithi ikulungele yini. I-Ivacaftor isekilasini lemithi ebizwa nge-cystic fibrosis transmembrane conductance regulator (CFTR) potentiators. Isebenza ngokuthuthukisa ukusebenza kweprotheni emzimbeni ukunciphisa ukwakheka kwamafinyila aminyene emaphashini nokwenza ngcono ezinye izimpawu ze-cystic fibrosis.

I-Ivacaftor iza njengethebhulethi futhi njengama-granules ukuthatha ngomlomo. Imvamisa kuthathwa ngokudla okunamafutha kabili ngosuku, ukuhlukaniswa kwamahora ayi-12. Thatha i-ivacaftor ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-ivacaftor njengoba nje iyalelwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Ukulungiselela umthamo wezinhlamvu ze-ivacaftor, hlanganisa lonke iphakethe lamagremu kusipuni esingu-1 (5 mL) sokudla okubandayo noma okushisa ekamelweni noma oketshezi olufana ne-yogurt, i-appleauce, amanzi, ubisi, ubisi lwebele, ubisi lwebele, noma ijusi. Thatha ingxube kungakapheli ihora eli-1 lokuxuba ama-granules nokudla noma uketshezi.

Thatha umthamo ngamunye we-ivacaftor ngokudla okunamafutha njengamaqanda, ibhotela, ibhotela lamantongomane, i-pizza yoshizi, imikhiqizo yobisi lonke (njengobisi lonke, ushizi, neyogathi), ifomula yezingane nobisi lwebele. Khuluma nodokotela wakho mayelana nokunye ukudla okunamafutha okufanele udle nge-ivacaftor.

I-Ivacaftor ilawula i-cystic fibrosis kepha ayiyelaphi. Qhubeka uthathe i-ivacaftor noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-ivacaftor ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-ivacaftor,

• Tshela udokotela wakho kanye nosokhemisi uma ungenwe i-ivacaftor, noma imiphi eminye imithi, noma iziphi izithako ezikumaphilisi e-ivacaftor. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunomsoco, okwenzayo noma ohlela ukukuthatha. Qinisekisa ukusho noma yikuphi kokulandelayo: ama-antibiotic athile afana ne-clarithromycin (i-Biaxin, e-PrevPac), i-erythromycin (i-E.E.S., i-E-Mycin, i-Ery-Tab, i-Erythrocin), ne-telithromycin (i-Ketek); ezinye izinto zokuvikela ezifana ne-fluconazole (i-Diflucan), i-itraconazole (i-Onmel, i-Sporanox), i-ketoconazole (i-Nizoral), i-posaconazole (i-Noxafil), ne-voriconazole (i-Vfend); i-cyclosporine (Gengraf, Neoral, Sandimmune); i-digoxin (i-Lanoxin); imithi ethile yokuquleka efana ne-carbamazepine (Carbatrol, Epitol, Tegretol, abanye), phenobarbital, ne-phenytoin (Dilantin, Phenytek); i-midazolam; i-rifabutin (i-Mycobutin); i-rifampin (iRifadin, eRifamate, eRifater, eRimactane); tacrolimus (Astagraf, Prograf), noma warfarin (Coumadin, Jantoven). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-ivacaftor, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• utshele udokotela wakho uma uke waba nesifo sesibindi noma sezinso.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-ivacaftor, shayela udokotela wakho.
• kufanele wazi ukuthi i-ivacaftor ingakwenza ube nesiyezi. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.

Ungadli isithelo samagilebhisi noma amawolintshi aseSeville noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Uma ukhumbula umthamo ongabanjwanga kungakapheli amahora angu-6 wesikhathi obehlelelwe ukuwuthatha, thatha umthamo ongabanjwanga ngokushesha ngokudla okuqukethe amafutha. Kodwa-ke, uma kudlule amahora angaphezu kwayi-6 kusukela ngesikhathi esihleliwe, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Ivacaftor ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• ukuqubuka
• ubuhlungu obuhlangene
• ubuhlungu bomlomo nomphimbo
• umkhuhlane, umphimbo obuhlungu, ukuphuma kwamakhala, noma ezinye izimpawu zokutheleleka
• isifo sohudo
• isiyezi

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• isicanucanu
• ukuhlanza
• ukulahlekelwa isifiso sokudla
• ubuhlungu engxenyeni engenhla kwesokudla yesisu
• umchamo omnyama
• ukukhathala ngokweqile
• ukopha okungajwayelekile noma ukulinyazwa
• ukuphuzi kwesikhumba noma kwamehlo
• umbono uyashintsha

I-Ivacaftor ingakhuphula ubungozi bokuthi wena noma ingane yakho nibe nezinkinga zamehlo. Khuluma nodokotela wakho noma udokotela wengane yakho ngezingozi zokuthatha lo muthi.

I-Ivacaftor ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• isiyezi
• isifo sohudo

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzoku-oda ukuhlolwa kwamehlo nokuhlolwa okuthile kwelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze uhlole impendulo yomzimba wakho ku-ivacaftor.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Kalydeco^®