Amaprotheni asebenza ngo-C

Amaprotheni asebenza nge-C (CRP) akhiqizwa yisibindi. Izinga le-CRP liyakhuphuka lapho kunokuvuvukala emzimbeni wonke. Ngenye yeqembu lamaprotheni abizwa ngokuthi ama-acute phase reactants akhuphuka ngokuphendula ukuvuvukala. Amazinga ama-acute phase reactants akhula ngokuphendula amaprotheni athile okuvuvukala abizwa ngama-cytokines. Lawa maprotheni akhiqizwa ngamaseli amhlophe egazi ngesikhathi sokuvuvukala.

Lo mbhalo ukhuluma ngokuhlolwa kwegazi okwenziwe ukukala inani leCRP egazini lakho.

Kudingeka isampula yegazi. Lokhu kuvame ukuthathwa emthanjeni. Inqubo ibizwa ngokuthi i-venipuncture.

Azikho izinyathelo ezikhethekile ezidingekayo ukulungiselela lolu vivinyo.

Lapho inaliti ifakwa ukudonsa igazi, abanye abantu bezwa ubuhlungu obulinganiselayo. Abanye bangazizwa nje ngokuhlatshwa noma ukuzwa okuhlabayo. Ngemuva kwalokho, kungahle kube nokushaywa okuthile.

Ukuhlolwa kweCRP ukuhlolwa okujwayelekile ukubheka ukuvuvukala emzimbeni. Akusona isivivinyo esithile. Lokho kusho ukuthi kungaveza ukuthi unokuvuvukala kwenye indawo emzimbeni wakho, kepha akukwazi ukukhomba indawo ngqo. Ukuhlolwa kweCRP kuvame ukwenziwa nge-ESR noma nge-sedimentation test test nayo ebheka ukuvuvukala.

Ungaba nalolu vivinyo ku:

• Hlola ukuqhuma kwezifo ezivuthayo ezifana nesifo samathambo, i-lupus, noma i-vasculitis.
• Thola ukuthi umuthi olwa nokuvuvukala uyasebenza yini ukwelapha isifo noma isimo.

Kodwa-ke, izinga eliphansi le-CRP akusho ngaso sonke isikhathi ukuthi akukho ukuvuvukala okukhona. Amaleveli e-CRP angeke akhuliswe kubantu abane-rheumatoid arthritis ne-lupus. Isizathu salokhu asaziwa.

Ukuhlolwa okubucayi kwe-CRP, okubizwa ngokuthi yi-high-sensitivity C-reactive test (hs-CRP) assay, kuyatholakala ukucacisa ubungozi bomuntu besifo senhliziyo.

Amanani ajwayelekile e-CRP ayahlukahluka kuye ngelabhu kuya kwelabhu. Ngokuvamile, kunamazinga aphansi we-CRP atholakalayo egazini. Amazinga avame ukwanda kancane ngokukhula, ubulili besifazane kanye nabase-Afrika baseMelika.

Ukwanda kwe-serum CRP kuhlobene nezici zendabuko zenhliziyo engcupheni futhi kungakhombisa indima yalezi zinto ezinobungozi ekubangeleni ukuvuvukala kwemithambo yegazi.

Ngokusho kwe-American Heart Association, imiphumela ye-hs-CRP ekunqumeni ubungozi besifo senhliziyo ingahunyushwa kanjena:

• Usengozini encane yokuthola isifo senhliziyo nemithambo yegazi uma izinga lakho le-hs-CRP liphansi kuno-1.0 mg / L.
• Usengozini enkulu yokuba nesifo senhliziyo uma amazinga akho aphakathi kuka-1.0 mg / L no-3.0 mg / L.
• Usengozini enkulu yesifo senhliziyo uma izinga lakho le-hs-CRP liphakeme kuno-3.0 mg / L.

Qaphela: Amabanga wamanani ajwayelekile angahluka kancane kumalabhorethri ahlukile. Khuluma nomhlinzeki wakho wezokunakekelwa kwempilo mayelana nencazelo yemiphumela yakho ethile yokuhlolwa.

Izibonelo ezingenhla zibonisa izilinganiso ezivamile zemiphumela yalezi zivivinyo. Amanye ama-laboratories asebenzisa izilinganiso ezahlukahlukene noma angahlola izinhlobo ezahlukene.

Ukuhlolwa okuqondile kusho ukuthi unokuvuvukala emzimbeni. Lokhu kungabangelwa izimo ezahlukahlukene, kufaka phakathi:

• Umdlavuza
• Izifo zezicubu ezixhuma
• Isifo senhliziyo
• Ukutheleleka
• Izifo zamathumbu ezivuthayo (IBD)
• ILupus
• Inyumoniya
• Isifo samathambo
• Umkhuhlane we-rheumatic fever
• Isifo sofuba

Lolu hlu aluhlanganisi konke.

Qaphela: Imiphumela emihle ye-CRP nayo iyenzeka engxenyeni yokugcina yokukhulelwa noma ngokusebenzisa amaphilisi okulawula ukubeletha (izivimbelinzalo zomlomo).

Izingozi ezihambisana nokudonswa igazi zincane, kepha zingafaka:

• Ukopha ngokweqile
• Ukuquleka noma uzizwe unekhanda elincane
• I-hematoma (ukuqoqwa kwegazi ngaphansi kwesikhumba)
• Ukutheleleka (ingozi encane noma kunini lapho isikhumba siphukile)

CRP; Amaprotheni asebenza ngokuzwela okuphezulu kakhulu we-C; hs-CRP

• Ukuhlolwa kwegazi

IChernecky CC, iBerger BJ. C. Ku: IChernecky CC, uBerger BJ, ama-eds. Ukuhlolwa Kwelabhoratri Nezinqubo Zokuxilonga. Umhlaka 6. ISt Louis, MO: Elsevier Saunders; 2013: 266-432.

UDJ wezokudla. Ama-amino acid, ama-peptide, namaprotheni. Ku: Rifai N, ed. I-Tietz Textbook ye-Clinical Chemistry kanye ne-Molecular Diagnostics. Umhlaka 6. ISt Louis, MO: Elsevier; 2018: isahluko 28.

Ridker PM, Libby P, Buring JE. Izimpawu zobungozi kanye nokuvimbela okuyinhloko kwesifo senhliziyo. Ku: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, ama-eds. Isifo Senhliziyo SikaBraunwald: Incwadi Yemithi Yezinhliziyo Nemithambo. Umhla ka-11. IPhiladelphia, PA: Elsevier; 2019: isahluko 45.