Ama-amino acid we-Plasma

I-Plasma amino acid ukuhlolwa kokuhlola okwenziwa ezinganeni ezibheka inani lama-amino acid egazini. Ama-amino acid ayizakhi zokwakha amaprotheni emzimbeni.

Isikhathi esiningi, igazi likhishwa emthanjeni ongaphakathi endololwaneni noma ngemuva kwesandla.

Ezinsaneni noma ezinganeni ezincane, ithuluzi elibukhali elibizwa ngokuthi i-lancet lingasetshenziselwa ukubhoboza isikhumba.

• Igazi liqoqa kuthubhu encane yengilazi ebizwa nge-pipette, noma kwi-slide noma kumugqa wokuhlola.
• Kubekwa ibhandishi phezu kwale ndawo ukunqanda ukuphuma kwegazi.

Isampuli yegazi ithunyelwa elebhu. Kunezinhlobo eziningi zezindlela ezisetshenziselwa ukunquma amazinga e-amino acid egazini.

Umuntu ohlolwayo akufanele adle amahora amane ngaphambi kokuhlolwa.

Kungaba nobuhlungu obuncane noma udosi lapho kufakwa inaliti. Ungase futhi uzizwe ushaywa yisiza ngemuva kokukhishwa kwegazi. Induku yenaliti kungenzeka idale ukuthi usana noma ingane ikhale.

Lokhu kuhlolwa kwenziwa ukukala izinga lama-amino acid egazini.

Izinga elikhulisiwe le-amino acid ethile liyisibonakaliso esinamandla. Lokhu kukhombisa ukuthi kunenkinga ngekhono lomzimba lokudiliza (ukugaya) i-amino acid.

Ukuhlolwa kungasetshenziselwa ukubheka amazinga anciphile ama-amino acid egazini.

Ukukhuphuka noma ukwehla kwamazinga ama-amino acid egazini kungenzeka ngemfiva, ukungondleki ngokwanele, kanye nezimo ezithile zezokwelapha.

Zonke izilinganiso zingama-micromoles ngelitha ngalinye (µmol / L). Amanani ajwayelekile angahluka phakathi kwamalabhorethri ahlukene. Khuluma nomhlinzeki wakho wezokunakekelwa kwempilo ngemiphumela yakho ethile yokuhlolwa.

U-Alanine:

• Izingane: 200 kuya ku-450
• Abantu abadala: 230 kuya ku-510

I-Alpha-aminoadipic acid:

• Izingane: azitholakalanga
• Abantu abadala: abatholakalanga

I-Alpha-amino-N-butyric acid:

• Izingane: 8 kuya ku-37
• Abantu abadala: 15 kuya ku-41

I-Arginine:

• Izingane: 44 kuya ku-120
• Abantu abadala: 13 kuya ku-64

I-Asparagine:

• Izingane: 15 kuya ku-40
• Abantu abadala: 45 kuya ku-130

I-Aspartic acid:

• Izingane: 0 kuya ku-26
• Abantu abadala: 0 kuye ku-6

I-beta-alanine:

• Izingane: 0 kuya ku-49
• Abantu abadala: 0 kuye ku-29

I-beta-amino-isobutyric acid:

• Izingane: azitholakalanga
• Abantu abadala: abatholakalanga

I-Carnosine:

• Izingane: azitholakalanga
• Abantu abadala: abatholakalanga

I-Citrulline:

• Izingane: 16 kuya ku-32
• Abantu abadala: 16 kuya ku-55

I-cystine:

• Izingane: 19 kuya ku-47
• Abantu abadala: 30 kuya ku-65

I-Glutamic acid:

• Izingane: 32 kuya ku-140
• Abantu abadala: 18 kuya ku-98

I-Glutamine:

• Izingane: 420 kuya ku-730
• Abantu abadala: 390 kuya ku-650

IGlycine:

• Izingane: 110 kuya ku-240
• Abantu abadala: 170 kuya ku-330

I-Histidine:

• Izingane: 68 kuya ku-120
• Abantu abadala: 26 kuya ku-120

I-Hydroxyproline:

• Izingane: 0 kuya ku-5
• Abantu abadala: abatholakalanga

Isoleucine:

• Izingane: 37 kuya ku-140
• Abantu abadala: 42 kuya ku-100

I-Leucine:

• Izingane: 70 kuya ku-170
• Abantu abadala: 66 kuya ku-170

I-Lysine:

• Izingane: 120 kuya ku-290
• Abantu abadala: 150 kuya ku-220

I-Methionine:

• Izingane: 13 kuya ku-30
• Abantu abadala: 16 kuya ku-30

1-methylhistidine:

• Izingane: azitholakalanga
• Abantu abadala: abatholakalanga

3-methylhistidine:

• Izingane: 0 kuye ku-52
• Abantu abadala: 0 kuye ku-64

I-Ornithine:

• Izingane: 44 kuya ku-90
• Abantu abadala: 27 kuya ku-80

I-Phenylalanine:

• Izingane: 26 kuya ku-86
• Abantu abadala: 41 kuya ku-68

I-Phosphoserine:

• Izingane: 0 kuya ku-12
• Abantu abadala: 0 to 12

I-Phosphoethanolamine:

• Izingane: 0 kuya ku-12
• Abantu abadala: 0 kuye ku-55

Ukuphenya:

• Izingane: 130 kuya ku-290
• Abantu abadala: 110 kuya ku-360

I-Serine:

• Izingane: 93 kuya ku-150
• Abantu abadala: 56 kuya ku-140

I-Taurine:

• Izingane: 11 kuya ku-120
• Abantu abadala: 45 kuya ku-130

Threonine:

• Izingane: 67 kuya ku-150
• Abantu abadala: 92 kuya ku-240

I-Tyrosine:

• Izingane: 26 kuya ku-110
• Abantu abadala: 45 kuya ku-74

I-Valine:

• Izingane: 160 kuya ku-350
• Abantu abadala: 150 kuya ku-310

Izibonelo ezingenhla zibonisa izilinganiso ezivamile zemiphumela yalezi zivivinyo. Amanye ama-laboratories asebenzisa izilinganiso ezahlukahlukene noma angahlola izinhlobo ezahlukene.

Ukwanda kwezinga eliphelele lama-amino acid egazini kungaba ngenxa:

• I-Eclampsia
• Iphutha lokuzalwa lomzimba
• Ukungabekezelelani kwe-Fructose
• I-Ketoacidosis (yesifo sikashukela)
• Ukuhluleka kwezinso
• I-Reye syndrome
• Iphutha laselebhu

Ukwehla kwezinga eliphelele lama-amino acid egazini kungaba ngenxa:

• Ukungasebenzi kahle kwe-adrenal cortical
• Imfiva
• Isifo seHartnup
• Iphutha lokuzalwa lomzimba
• IHuntington chorea
• Ukungondleki
• I-Nephrotic syndrome
• Umkhuhlane wePhlebotomus
• Isifo samathambo
• Iphutha laselebhu

Amanani aphakeme noma aphansi e-plasma amino acid ngamunye kufanele abhekwe neminye imininingwane. Imiphumela engajwayelekile ingahle ibangelwe ukudla, izinkinga zofuzo, noma imiphumela yomuthi.

Ukuhlola izinsana zamazinga akhuphukile ama-amino acid kungasiza ekutholeni izinkinga nge-metabolism. Ukwelashwa kwasekuqaleni kwalezi zimo kungavimbela izinkinga ngokuzayo.

Amino acid ukuhlolwa kwegazi

• Ama-amino acid

UDJ wezokudla. Ama-amino acid, ama-peptide, namaprotheni. Ku: Rifai N, ed. I-Tietz Textbook ye-Clinical Chemistry kanye ne-Molecular Diagnostics. Umhlaka 6. ISt Louis, MO: Elsevier; 2018: isahluko 28.

IKliegman RM, iSt. Geme JW, iBlum NJ, i-Shah SS, iTasker RC, iWilson KM. Amaphutha ku-metabolism yama-amino acid. Ku: Kliegman RM, St Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Incwadi kaNelson Yezingane. Umhlaka 21. IPhiladelphia, PA: Elsevier; 2020: isahl. 103.

URiley RS, uMcPherson RA. Ukuhlolwa okuyisisekelo komchamo. Ku: McPherson RA, Pincus MR, abahleli. UHenry’s Clinical Diagnosis and Management by Laboratory Methods. Umhla ka-23. ISt Louis, MO: Elsevier; 2017: isahluko 28.