Ukuhlolwa kwegazi le-Porphyrins

Ama-Porphyrins asiza ukwakha izinto eziningi ezibalulekile emzimbeni. Enye yazo i-hemoglobin. Le yiprotheni kumaseli abomvu egazi athwala umoya-mpilo egazini.

Ama-Porphyrins angalinganiswa egazini noma emchameni. Lo mbhalo ukhuluma ngokuhlolwa kwegazi.

Kudingeka isampula yegazi.

Isampula bese lifakwa eqhweni bese liyiswa ngokushesha elabhorethri. Ama-porphyrin amathathu ngokuvamile angalinganiswa ngamanani amancane egazini lomuntu. Kunjalo:

• ICoproporphyrin
• I-Protoporphyrin (PROTO)
• I-Uroporphyrin

I-Protoporphyrin imvamisa itholakala ngenani eliphakeme kakhulu. Ukuhlolwa okuningi kuyadingeka ukukhombisa amazinga ama-porphyrins athile.

Akufanele udle amahora ayi-12 kuya kwayi-14 ngaphambi kwalokhu kuhlolwa. Ungaphuza amanzi ngaphambi kokuhlolwa. Imiphumela yakho yokuhlolwa ingathinteka uma ungalandeli le miyalo.

Lapho inaliti ifakwa ukudonsa igazi, abanye abantu bezwa ubuhlungu obulinganiselayo. Abanye bazizwa beshaywa noma betinyelwa kuphela. Ngemuva kwalokho, kungahle kube nokushaywa okuthile noma ukulinyazeka okuncane. Lokhu maduzane kuyaphela.

Lokhu kuhlolwa kusetshenziselwa ukuxilonga ama-porphyrias. Leli yiqembu lezinkinga ezingavamile ezivame ukudluliselwa ngamalungu omndeni.

Ingasetshenziswa futhi nezinye izivivinyo ukuthola ubuthi bomthofu nohlelo oluthile lwezinzwa nokuphazamiseka kwesikhumba.

Lokhu kuhlolwa kukala ngqo amazinga aphelele we-porphyrin. Kepha, amanani esithenjwa (uhla lwamanani abonwe eqenjini labantu abaphilile) lwezinto ngazinye zifakiwe:

• Ingqikithi yamazinga e-porphyrin: 0 kuya ku-1.0 mcg / dL (0 kuye ku-15 nmol / L)
• Izinga leCoproporphyrin: 2 mcg / dL (30 nmol / L)
• Izinga le-Protoporphyrin: 16 kuya ku-60 mcg / dL (0.28 kuya ku-1.07 µmol / L)
• Izinga le-Uroporphyrin: 2 mcg / dL (2.4 nmol / L)

Ububanzi bamanani ajwayelekile bungahluka kancane phakathi kwamalabhorethri ahlukene. Amanye amalebhu asebenzisa izilinganiso ezahlukahlukene noma avivinye amasampula ahlukile. Khuluma nodokotela wakho mayelana nencazelo yemiphumela yakho ethile yokuhlolwa.

Amazinga akhuphukile ama-coproporphyrins angaba uphawu lwe:

• I-erythropoietic porphyria ezalwa nayo
• I-hepatic coproporphyria
• I-anemia ye-Sideroblastic
• I-variegate porphyria

Izinga le-protoporphyrin elandisiwe lingaba uphawu lwe:

• Ukushoda kwegazi kwezifo ezingamahlalakhona
• I-protoporphyria yokuzalwa erythropoietic
• Ukwanda kwe-erythropoiesis
• Ukutheleleka
• Ukushoda kwe-iron anemia
• Ubuthi bomthofu
• I-anemia ye-Sideroblastic
• Thalassemia
• I-variegate porphyria

Izinga le-uroporphyrin elikhulile lingaba uphawu lwe:

• I-erythropoietic porphyria ezalwa nayo
• I-Porphyria cutanea tarda

Kunengozi encane ethintekayo ekuthatheni igazi lakho. Imithambo nemithambo iyehluka ngobukhulu ukusuka komunye umuntu iye komunye, futhi kusukela kolunye uhlangothi lomzimba kuye kolunye. Ukuthola isampula yegazi kwabanye abantu kungaba nzima kakhulu ukwedlula kwabanye.

Ezinye izingozi ezihambisana nokudonswa igazi zincane, kepha zingafaka:

• Ukopha ngokweqile
• Ukuquleka noma uzizwe unekhanda elincane
• Ukubhoboza okuningi ukuthola imithambo
• I-hematoma (ukuqoqwa kwegazi ngaphansi kwesikhumba)
• Ukutheleleka (ingozi encane noma kunini lapho isikhumba siphukile)

Amazinga e-Protoporphyrin; Ama-Porphyrins - inani; Amazinga we-Coproporphyrin; Isivivinyo se-PROTO

• Ukuhlolwa kwegazi

IChernecky CC, iBerger BJ. Ama-Porphyrins, amanani - igazi. Ku: IChernecky CC, iBerger BJ, ama-eds. Ukuhlolwa Kwelabhoratri Nezinqubo Zokuxilonga. Umhlaka 6. ISt Louis, MO: Elsevier Saunders; 2013: 891-892.

I-Fuller SJ, iWiley JS. I-Heme biosynthesis nokuphazamiseka kwayo: i-porphyrias kanye ne-sideroblastic anemias. Ku: Hoffman R, Benz EJ, Silberstein LE, et al, ama-eds. I-Hematology: Izimiso Eziyisisekelo Nokuzijwayeza. Umhla wesi-7. IPhiladelphia, PA: Elsevier; 2018: isahluko 38.