Ukuhlolwa kwegazi le-TBG

Ukuhlolwa kwegazi kwe-TBG kukala izinga leprotheyini elihambisa i-hormone yegilo emzimbeni wakho wonke. Le protein ibizwa nge-thyroxine binding globulin (TBG).

Kuthathwa isampuli yegazi bese ithunyelwa elabhorethri ukuze ihlolwe.

Izidakamizwa ezithile kanye nemithi kungathinta imiphumela yokuhlolwa. Umhlinzeki wakho wezokunakekelwa kwempilo angakutshela ukuthi uyeke ukuthatha umuthi othize isikhashana ngaphambi kokuhlolwa. Ungalokothi uyeke ukuthatha noma imuphi umuthi ngaphandle kokuqala ukhulume nomhlinzeki wakho.

Le mithi nezidakamizwa kungakhuphula izinga le-TBG:

• Ama-Estrogens, atholakala kumaphilisi okulawula ukubeletha kanye nasekwelapheni i-estrogen
• I-Heroin
• I-Methadone
• Ama-phenothiazines (imishanguzo ethile yokulwisana nokugula ngengqondo)

Imithi elandelayo inganciphisa amazinga e-TBG:

• I-Depakote noma i-depakene (ebizwa nangokuthi i-valproic acid)
• I-Dilantin (ebizwa nangokuthi i-phenytoin)
• Amanani aphezulu ama-salicylates, kufaka phakathi i-aspirin
• Amahomoni wesilisa, kufaka phakathi i-androgens ne-testosterone
• Prednisone

Lapho inaliti ifakwa ukudonsa igazi, abanye abantu bezwa ubuhlungu obulinganiselayo. Abanye bazizwa beshaywa noma betinyelwa kuphela. Ngemuva kwalokho, kungahle kube nokushaywa okuthile noma ukulinyazeka okuncane. Lokhu maduzane kuyaphela.

Lokhu kuhlolwa kungenziwa ukuthola izinkinga nge-thyroid yakho.

Ibanga elijwayelekile lingama-micrograms ayi-13 kuya kwangu-39 nge-deciliter ngayinye (mcg / dL), noma ama-nanomoles ayi-150 kuye kwangama-360 ilitha ngalinye (nmol / L).

Ububanzi bamanani ajwayelekile bungahluka kancane phakathi kwamalabhorethri ahlukene. Amanye amalebhu asebenzisa izilinganiso ezahlukahlukene noma angahlola amasampula ahlukile. Khuluma nomhlinzeki wakho mayelana nencazelo yemiphumela yakho ethile yokuhlolwa.

Izinga le-TBG elandisiwe kungenzeka ngenxa ye:

• I-porphyria ngezikhathi ezithile (isifo esingajwayelekile somzimba)
• I-Hypothyroidism (i-thyroid engasebenzi)
• Isifo sesibindi
• Ukukhulelwa (amazinga e-TBG ngokuvamile akhula ngesikhathi sokukhulelwa)

Qaphela: Amazinga e-TBG ngokuvamile aphezulu ezinganeni ezisanda kuzalwa.

Ukwehla kwamazinga e-TBG kungenzeka kungenxa yalokhu:

• Ukugula okunamandla
• I-Acromegaly (ukuphazamiseka okubangelwa i-hormone yokukhula eningi kakhulu)
• I-Hyperthyroidism (i-thyroid engasebenzi ngokweqile)
• Ukungondleki
• I-Nephrotic syndrome (izimpawu ezibonisa ukulimala kwezinso zikhona)
• Ukucindezeleka okuvela ekuhlinzekeni

Amazinga aphezulu noma aphansi e-TBG athinta ubudlelwane obuphakathi kwe-T4 ephelele nokuhlolwa kwegazi kwama-T4 kwamahhala. Ukuguqulwa kwamazinga egazi le-TBG kungashintsha umthamo ofanele wokushintshwa kwe-levothyroxine kubantu abane-hypothyroidism.

Kunengozi encane ethintekayo ekuthatheni igazi lakho. Imithambo nemithambo yegazi kuyahluka ngosayizi komunye umuntu kuya kolunye uhlangothi lomzimba kuya kolunye. Ukuthola isampula yegazi kwabanye abantu kungaba nzima kakhulu ukwedlula kwabanye.

Ezinye izingozi zokudonswa igazi zincane, kepha zingafaka:

• Ukopha ngokweqile
• Ukuquleka noma uzizwe unekhanda elincane
• Ukubhoboza okuningi ukuthola imithambo
• I-hematoma (i-blood buildup ngaphansi kwesikhumba)
• Ukutheleleka (ingozi encane noma kunini lapho isikhumba siphukile)

I-serum thyroxine ebopha i-globulin; Izinga le-TBG; Izinga le-Serum TBG; I-Hypothyroidism - i-TBG; Hyperthyroidism - TBG; I-thyroid engasebenzi - i-TBG; Indlala yegilo - TBG

• Ukuhlolwa kwegazi

UGuber HA, uFarag AF. Ukuhlolwa komsebenzi we-endocrine. Ku: McPherson RA, Pincus MR, abahleli. UHenry’s Clinical Diagnosis and Management by Laboratory Methods. Umhla ka-23. ISt Louis, MO: Elsevier; 2017: isahluko 24.

UKruse JA. Izinkinga ze-thyroid. Ku: Parrillo JE, Dellinger RP, ama-eds. Imithi Yokunakekelwa Okubalulekile: Izimiso Zokuxilongwa Nokuphathwa Kwabantu Abadala. Umhlaka 5. IPhiladelphia, PA: Elsevier; 2019: isahluko 57.

USalvatore D, uCohen R, uKopp PA, uLarsen PR. I-pathophysiology ye-thyroid nokuhlolwa kokuxilongwa. Ku: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, abahleli. Incwadi kaWilliams ye-Endocrinology. Umhlaka 14. IPhiladelphia, PA: Elsevier; 2020: isahluko 11.