Ukuhlolwa kwegazi kwe-LDH isoenzyme

Ukuhlolwa kwe-lactate dehydrogenase (LDH) isoenzyme kubheka ukuthi zingaki izinhlobo ezahlukahlukene ze-LDH ezisegazini.

Kudingeka isampula yegazi.

Umhlinzeki wezokunakekelwa kwempilo angakutshela ukuthi uyeke ukuthatha imithi ethile okwesikhashana ngaphambi kokuhlolwa.

Izidakamizwa ezingakhuphula izilinganiso ze-LDH zifaka:

• Izinzwa zokubulala izinzwa
• I-Aspirin
• I-Colchicine
• Clofibrate
• Cocaine
• Ama-fluorides
• Mithramycin
• Izidakamizwa
• I-Procainamide
• Izitatimende
• Ama-steroid (ama-glucocorticoids)

Ungayeki ukuthatha noma imuphi umuthi ngaphambi kokukhuluma nomhlinzeki wakho.

Lapho kufakwa inaliti ukuze kutholakale igazi, abanye abantu bezwa ubuhlungu obuncane. Abanye bazizwa beshaywa noma betinyelwa kuphela. Ngemuva kwalokho, kungahle kube nokushaywa okuthile noma ukulimazeka okuncane. Lokhu maduzane kuyaphela.

I-LDH iyi-enzyme etholakala ezicutshini eziningi zomzimba njengenhliziyo, isibindi, izinso, imisipha yamathambo, ubuchopho, amaseli egazi namaphaphu. Lapho izicubu zomzimba zilimele, i-LDH idedelwa iye egazini.

Ukuhlolwa kwe-LDH kusiza ukunquma indawo yokulimala kwezicubu.

I-LDH ikhona ngezinhlobo ezinhlanu, ezahluke kancane ngesakhiwo.

• I-LDH-1 itholakala ngokuyinhloko emisipheni yenhliziyo namaseli abomvu egazi.
• I-LDH-2 igxile kumaseli amhlophe egazi.
• I-LDH-3 iphezulu kakhulu emaphashini.
• I-LDH-4 iphezulu kunezinso, i-placenta, namanyikwe.
• I-LDH-5 iphezulu kakhulu emisipheni yesibindi nethambo.

Konke lokhu kungalinganiswa egazini.

Amazinga e-LDH aphezulu kunokujwayelekile angaphakamisa:

• I-hemolytic anemia
• I-Hypotension
• I-mononucleosis ethathelwanayo
• Ischemia yamathumbu (ukushoda kwegazi) kanye ne-infarction (ukufa kwezicubu)
• Ischemic cardiomyopathy
• Isifo sesibindi njenge-hepatitis
• Ukufa kwezicubu zomzimba
• Ukulimala kwemisipha
• Ukukhubazeka kwemisipha
• I-Pancreatitis
• Ukufa kwezicubu zomzimba
• Unhlangothi

Kunobungozi obuncane bokuthathwa kwegazi lakho. Imithambo nemithambo yegazi kuyahluka ngosayizi komunye umuntu kuya kolunye uhlangothi lomzimba kuya kolunye. Ukuthatha igazi kwabanye abantu kungaba nzima kakhulu ukwedlula kwabanye.

Ezinye izingozi ezihambisana nokudonswa igazi zincane kepha zingafaka:

• Ukopha ngokweqile
• Ukuquleka noma uzizwe unekhanda elincane
• Ukubhoboza okuningi ukuthola imithambo
• I-hematoma (ukuqoqwa kwegazi ngaphansi kwesikhumba)
• Ukutheleleka (ingozi encane noma kunini lapho isikhumba siphukile)

LD; LDH; I-Lactic (lactate) dehydrogenase isoenzymes

• Ukuhlolwa kwegazi

ICarty RP, iPincus MR, iSarafraz-Yazdi E.I-enzymology yomtholampilo. Ku: McPherson RA, Pincus MR, abahleli. UHenry’s Clinical Diagnosis and Management by Laboratory Methods. Umhla ka-23. ISt Louis, MO: Elsevier; I-2017: isahluko 20.

IChernecky CC, iBerger BJ. I-isoenzymes ye-Lactate dehydrogenase (LD). Ku: IChernecky CC, iBerger BJ, ama-eds. Ukuhlolwa Kwelabhoratri Nezinqubo Zokuxilonga. Umhlaka 6. ISt Louis, MO: Elsevier Saunders; 2013: 702-703.