I-serum globulin electrophoresis

Ukuhlolwa kwe-serum globulin electrophoresis kukala amazinga wamaprotheni abizwa ngama-globulin engxenyeni ewuketshezi yesampula segazi. Lolu ketshezi lubizwa ngokuthi yi-serum.

Kudingeka isampula yegazi.

Kulebhu, uchwepheshe ubeka isampula segazi ephepheni elikhethekile bese efaka amandla kagesi. Amaprotheni ahamba ephepheni futhi akha ama-band akhombisa inani leprotheyini ngalinye.

Landela imiyalo yokuthi udinga ukuzila ukudla ngaphambi kwalolu vivinyo noma cha.

Imithi ethile ingathinta imiphumela yalokhu kuhlolwa. Umhlinzeki wakho wokunakekelwa kwezempilo uzokutshela uma udinga ukuyeka ukusebenzisa noma imiphi imithi. Ungayeki noma imuphi umuthi ngaphambi kokukhuluma nomhlinzeki wakho.

Lapho inaliti ifakwa ukudonsa igazi, abanye abantu bezwa ubuhlungu obulinganiselayo. Abanye bazizwa beshaywa noma betinyelwa kuphela. Ngemuva kwalokho, kungahle kube nokushaywa okuthile noma ukulimazeka okuncane. Lokhu maduzane kuyaphela.

Lokhu kuhlolwa kwenziwa ukubheka amaprotheni e-globulin egazini. Ukuhlonza izinhlobo zama-globulin kungasiza ukuxilonga izinkinga ezithile zezokwelapha.

Ama-globulin ahlukaniswe cishe ngamaqembu amathathu: i-alpha, i-beta, ne-gamma globulins. Ama-glob globulins afaka izinhlobo ezahlukahlukene zama-antibodies afana nama-immunoglobulins (Ig) M, G, no-A.

Izifo ezithile zihlotshaniswa nokukhiqiza ama-immunoglobulin amaningi kakhulu. Isibonelo, iWaldenstrom macroglobulinemia ingumdlavuza wamangqamuzana athile amhlophe egazi. Kuxhunyaniswe nokukhiqiza ama-antibody amaningi e-IgM.

Amabanga amanani ajwayelekile yilawa:

• I-serum globulin: 2.0 kuya ku-3.5 amagremu nge-deciliter ngayinye (g / dL) noma ngama-gramu angama-20 kuye kwangama-35 ilitha (g / L)
• Ingxenye ye-IgM: ama-milligram angama-75 kuya kwangama-300 nge-deciliter (mg / dL) noma ama-milligram angama-750 kuya ku-3,000 ngelitha (mg / L)
• Ingxenye ye-IgG: 650 kuya ku-1,850 mg / dL noma ku-6.5 kuye ku-18.50 g / L
• Ingxenye ye-IgA: 90 kuye ku-350 mg / dL noma ku-900 kuye ku-3,500 mg / L

Ububanzi bamanani ajwayelekile bungahluka kancane phakathi kwamalabhorethri ahlukene. Amanye amalebhu asebenzisa izilinganiso ezahlukahlukene noma avivinye amasampula ahlukile. Khuluma nomhlinzeki wakho mayelana nencazelo yemiphumela yakho ethile yokuhlolwa.

Amaprotheni akhuphukile e-gamma globulin angakhombisa:

• Ukutheleleka okunamandla
• Umdlavuza wegazi nomnkantsha okubandakanya ama-myeloma amaningi, namanye ama-lymphomas nama-leukemias
• Ukuphazamiseka kwamasosha omzimba
• Isifo sesikhathi eside (esingapheli) sokuvuvukala (isibonelo, isifo samathambo kanye ne-systemic lupus erythematosus)
• I-Waldenström macroglobulinemia

Kunengozi encane kakhulu ethintekayo ekuthatheni igazi lakho. Imithambo nemithambo iyehluka ngobukhulu ukusuka komunye umuntu iye komunye, futhi kusukela kolunye uhlangothi lomzimba kuye kolunye. Ukuthatha igazi kwabanye abantu kungaba nzima kakhulu ukwedlula kwabanye.

Ezinye izingozi ezihambisana nokudonswa igazi zincane, kepha zingafaka:

• Ukopha ngokweqile
• Ukuquleka noma uzizwe unekhanda elincane
• Ukubhoboza okuningi ukuthola imithambo
• I-hematoma (i-blood buildup ngaphansi kwesikhumba)
• Ukutheleleka (ingozi encane noma kunini lapho isikhumba siphukile)

Ama-immunoglobulin amaningi

• Ukuhlolwa kwegazi

IChernecky CC, iBerger BJ. I-Immunoelectrophoresis - i-serum nomchamo. Ku: IChernecky CC, iBerger BJ, ama-eds. Ukuhlolwa Kwelabhoratri Nezinqubo Zokuxilonga. Umhlaka 6. ISt Louis, MO: Elsevier Saunders; 2013: 667-692.

UDominiczak MH, uFraser WD. Amaprotheni egazi ne-plasma. Ku: Baynes JW, Dominiczak MH, ama-eds. I-Medical Biochemistry. Umhlaka 5. IPhiladelphia, PA: Elsevier; 2019: isahluko 40.