I-antigen ye-HLA-B27

I-HLA-B27 ukuhlolwa kwegazi ukubheka iphrotheni etholakala ebusweni bamaseli amhlophe egazi. Amaprotheni abizwa ngokuthi yi-human leukocyte antigen B27 (HLA-B27).

Ama-antigen leukocyte antigen (HLAs) angamaprotheni asiza amasosha omzimba ukuthi atshele umehluko phakathi kwamaseli awo nezinto zangaphandle, eziyingozi. Zenziwe ngemiyalo yizakhi zofuzo.

Kudingeka isampula yegazi. Isikhathi esiningi, igazi likhishwa emthanjeni ongaphakathi endololwaneni noma ngemuva kwesandla.

Ezimweni eziningi, azikho izinyathelo ezikhethekile ezidingekayo ukulungiselela isivivinyo.

Lapho inaliti ifakwa ukudonsa igazi, ungezwa ubuhlungu obulinganiselayo, noma umuzwa ohlabayo noma olumayo kuphela. Ngemuva kwalokho, kungahle kube nokushaywa okuthile.

Umhlinzeki wakho wezokunakekelwa kwempilo anga-oda lokhu kuhlolwa ukusiza ukuthola imbangela yobuhlungu obuhlangene, ukuqina, noma ukuvuvukala. Ukuhlolwa kungenziwa kanye nezinye izivivinyo, kufaka phakathi:

• Amaprotheni asebenza ngo-C
• Izinga le-sedimentation ye-Erythrocyte (ESR)
• Isici se-rheumatoid
• Ama-X-ray

Ukuhlolwa kwe-HLA kusetshenziselwa ukufanisa izicubu ezinikelwe nezicubu zomuntu othola ukufakelwa komzimba. Isibonelo, kungenziwa lapho umuntu edinga ukufakelwa izinso noma ukufakelwa umnkantsha wethambo.

Umphumela ojwayelekile (ongemuhle) usho ukuthi i-HLA-B27 ayikho.

Ukuhlolwa okusho ukuthi i-HLA-B27 ikhona. Iphakamisa ingozi enkulu kune-avareji yokuthuthukisa noma ukuba nokuphazamiseka okuthile okuzenzakalelayo. I-autoimmune disorder yisimo esenzeka lapho amasosha omzimba ehlasela ngephutha futhi abhubhise izicubu zomzimba ezinempilo.

Umphumela omuhle ungasiza umhlinzeki wakho enze ukuxilongwa kohlobo lwe-arthritis olubizwa nge-spondyloarthritis. Lolu hlobo lwe-arthritis lubandakanya ukuphazamiseka okulandelayo:

• I-Ankylosing spondylitis
• I-arthritis ehlobene nesifo sikaCrohn noma i-ulcerative colitis
• I-Psoriatic arthritis (i-arthritis ehlotshaniswa ne-psoriasis)
• I-arthritis esebenzayo
• Sacroiliitis (ukuvuvukala kwenhlanganisela ye-sacroiliac)
• Uveitis

Uma unezimpawu noma izimpawu ze-spondyloarthritis, ukuhlolwa okuhle kwe-HLA-B27 kungasiza ukuqinisekisa ukuxilongwa. Kodwa-ke, i-HLA-B27 itholakala kubantu abajwayelekile futhi akusho ukuthi njalo unesifo.

Izingozi zokutholwa ngegazi zincane, kepha zingafaka:

• Ukopha ngokweqile
• Ukuquleka noma uzizwe unekhanda elincane
• I-hematoma (ukuqoqwa kwegazi ngaphansi kwesikhumba)
• Ukutheleleka (ingozi encane noma kunini lapho isikhumba siphukile)

I-antigen leukocyte antigen B27; I-Ankylosing spondylitis-HLA; I-Psoriatic arthritis-HLA; I-arthritis esebenzayo-HLA

• Ukuhlolwa kwegazi

IChernecky CC, iBerger BJ. I-Human Leukocyte Antigen (HLA) B-27 - igazi. Ku: IChernecky CC, iBerger BJ, ama-eds. Ukuhlolwa Kwelabhoratri Nezinqubo Zokuxilonga. Umhlaka 6. ISt Louis, MO: Elsevier Saunders; 2013: 654-655.

UFagoaga NOMA. I-antigen ye-leukocyte antigen: okuyinkimbinkimbi enkulu ye-histocompatibility yomuntu. Ku: McPherson RA, Pincus MR, abahleli. UHenry’s Clinical Diagnosis and Management by Laboratory Methods. Umhla ka-23. ISt Louis, MO: Elsevier; 2017: isahluko 49.

Inman RD. Ama-spondyloarthropathies. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-25. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 265.

UMcPherson RA, Massey HD. Sibutsetelo samasosha omzimba kanye nokuphazamiseka komzimba. Ku: McPherson RA, Pincus MR, abahleli. UHenry’s Clinical Diagnosis and Management by Laboratory Methods. Umhla ka-23. ISt Louis, MO: Elsevier; I-2017: isahluko 43.

Reveille JD. I-Spondyloarthritis. Ku: Rich RR, Fleisher TA, Shearer WT, Schroeder HW, Bambalwa AJ, Weyand CM, eds. I-Clinical Immunology: Izimiso Nokwenza. Umhlaka 5. IPhiladelphia, PA: Elsevier; 2019: isahluko 57.