Ukuhlolwa komchamo we-PBG

I-Porphobilinogen (PBG) ingenye yezinhlobo eziningana zama-porphyrins atholakala emzimbeni wakho. Ama-Porphyrins asiza ukwakha izinto eziningi ezibalulekile emzimbeni. Enye yazo i-hemoglobin, iphrotheni emangqamuzaneni abomvu egazi athwala umoya-mpilo egazini. Ama-Porphyrins ngokuvamile ashiya umzimba wakho ngomchamo noma indle. Uma le nqubo ingenzeki, ama-porphyrins afana ne-PBG angakha emzimbeni wakho.

Lo mbhalo uchaza isivivinyo ukukala inani le-PBG kusampula yomchamo.

Ngemuva kokunikeza isampula yomchamo, iyahlolwa ebhodini. Lokhu kubizwa ngokuthi yisampula yomchamo engahleliwe.

Uma kudingeka, umhlinzeki wakho wezokunakekelwa kwempilo angakucela ukuthi uqoqe umchamo wakho ekhaya ngaphezu kwamahora angama-24. Lokhu kubizwa ngokuthi yisampula yamahora angama-24. Umhlinzeki wakho uzokutshela ukuthi ungakwenza kanjani lokhu. Landela imiyalo ngqo.

Umhlinzeki wakho angakutshela ukuthi uyeke ukuthatha imishanguzo okwesikhashana okungathinta imiphumela yokuhlolwa. Qiniseka ukuthi utshela umhlinzeki wakho ngayo yonke imithi oyiphuzayo. Lokhu kufaka phakathi:

• Ama-antibiotic nemithi elwa nefungal
• Izidakamizwa ezilwa nokukhathazeka
• Amaphilisi okuvimbela inzalo
• Imithi yesifo sikashukela
• Imithi yezinhlungu
• Imithi yokulala

Ungalokothi uyeke ukuthatha noma imuphi umuthi ngaphandle kokuqala ukhulume nomhlinzeki wakho.

Lokhu kuhlolwa kuhilela ukuchama okuvamile kuphela, futhi akukho ukungaphatheki kahle.

Lokhu kuhlolwa kungenziwa uma umhlinzeki wakho esola i-porphyria noma esinye isifo esihlobene nezinga le-PBG elingajwayelekile.

Ngesampula yomchamo engahleliwe, umphumela wokuhlolwa omubi uthathwa njengokujwayelekile.

Uma ukuhlolwa kwenziwa kusampula yamahora angama-24, inani elijwayelekile lingaphansi kwama-milligram ama-4 ngamahora angama-24 (ama-micromoles ayi-18 ngamahora angama-24).

Ububanzi bamanani ajwayelekile bungahluka kancane phakathi kwamalabhorethri ahlukene. Amanye amalebhu asebenzisa izilinganiso ezahlukahlukene noma angahlola izinhlobo ezihlukile. Khuluma nomhlinzeki wakho mayelana nencazelo yemiphumela yakho ethile yokuhlolwa.

Izinga elikhulisiwe le-PBG emchameni kungenzeka ngenxa:

• Isibindi
• Ubuthi bomthofu
• Umdlavuza wesibindi
• I-Porphyria (izinhlobo eziningana)

Azikho izingozi ngalokhu kuhlolwa.

Ukuhlolwa kwe-Porphobilinogen; I-Porphyria - umchamo; I-PBG

• Uhlelo lwesilisa lomchamo

I-Fuller SJ, iWiley JS. I-Heme biosynthesis nokuphazamiseka kwayo: i-porphyrias kanye ne-sideroblastic anemias. Ku: Hoffman R, Benz EJ, Silberstein LE, et al, ama-eds. I-Hematology: Izimiso Eziyisisekelo Nokuzijwayeza. Umhla wesi-7. IPhiladelphia, PA: Elsevier; 2018: isahluko 38.

URiley RS, uMcPherson RA. Ukuhlolwa okuyisisekelo komchamo. Ku: McPherson RA, Pincus MR, abahleli. UHenry’s Clinical Diagnosis and Management by Laboratory Methods. Umhla ka-23. ISt Louis, MO: Elsevier; 2017: isahluko 28.