Ukuhlolwa kwe-Glucose-6-phosphate dehydrogenase

IGlucose-6-phosphate dehydrogenase (G6PD) yiprotheni esiza amangqamuzana abomvu egazi ukuthi asebenze kahle. Ukuhlolwa kwe-G6PD kubheka inani (umsebenzi) wale nto kumaseli abomvu egazi.

Kudingeka isampula yegazi.

Akukho ukulungiselela okukhethekile okudingeka njalo.

Lapho inaliti ifakwa ukudonsa igazi, abanye abantu bezwa ubuhlungu obulinganiselayo. Abanye bazizwa beshaywa noma betinyelwa kuphela. Ngemuva kwalokho, kungahle kube nokushaywa okuthile noma ukulimazeka okuncane. Lokhu maduzane kuyaphela.

Umhlinzeki wakho wokunakekelwa kwezempilo angancoma lokhu kuhlolwa uma unezimpawu zokushoda kwe-G6PD. Lokhu kusho ukuthi awunawo umsebenzi owanele we-G6PD.

Umsebenzi omncane kakhulu we-G6PD uholela ekubhujisweni kwamaseli abomvu egazi. Le nqubo ibizwa ngokuthi i-hemolysis. Lapho le nqubo yenzeka ngenkuthalo, ibizwa ngesiqephu se-hemolytic.

Iziqephu ze-Hemolytic zingabangelwa ukutheleleka, ukudla okuthile (okufana nobhontshisi we-fava), nemithi ethile, kufaka phakathi:

• Izidakamizwa ezisetshenziselwa ukunciphisa umkhuhlane
• I-Nitrofurantoin
• I-Phenacetin
• Okuphambili
• AmaSulfonamides
• Izidakamizwa ze-Thiazide
• I-Tolbutamide
• I-Quinidine

Amanani ajwayelekile ayahluka futhi ancike kulabhorethri esetshenzisiwe. Amanye amalebhu asebenzisa izilinganiso ezahlukahlukene noma avivinye amasampula ahlukile. Khuluma nomhlinzeki wakho mayelana nencazelo yemiphumela yakho ethile yokuhlolwa.

Imiphumela engajwayelekile isho ukuthi unokushoda kwe-G6PD. Lokhu kungadala i-hemolytic anemia ezimweni ezithile.

Kunengozi encane ethintekayo ekuthatheni igazi lakho. Imithambo nemithambo yegazi kuyahluka ngosayizi komunye umuntu kuya kolunye uhlangothi lomzimba kuya kolunye. Ukuthola isampula yegazi kwabanye abantu kungaba nzima kakhulu ukwedlula kwabanye.

Ezinye izingozi ezihambisana nokudonswa igazi zincane, kepha zingafaka:

• Ukopha ngokweqile
• Ukuquleka noma uzizwe unekhanda elincane
• Ukubhoboza okuningi ukuthola imithambo
• I-hematoma (i-blood buildup ngaphansi kwesikhumba)
• Ukutheleleka (ingozi encane noma kunini lapho isikhumba siphukile)

Ukuhlolwa kwe-RBC G6PD; Isikrini se-G6PD

IChernecky CC, iBerger BJ. I-Glucose-6-phosphate dehydrogenase (G6PD, G-6-PD), inani - legazi. Ku: IChernecky CC, iBerger BJ, ama-eds. Ukuhlolwa Kwelebhu kanye Nezinqubo Zokuxilonga. Umhlaka 6. ISt Louis, MO: Elsevier Saunders; 2013: 594-595.

IGallagher PG. Ama-anemia we-hemolytic: ulwelwesi lwegazi elibomvu nokukhubazeka komzimba. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-26. IPhiladelphia, PA: Elsevier; 2020: isahluko152.