Ukuhlolwa kwe-Erythropoietin

Ukuhlolwa kwe-erythropoietin kukala inani le-hormone ebizwa ngokuthi i-erythropoietin (EPO) egazini.

I-hormone itshela ama-stem cells emnkantsheni wethambo ukuthi enze amangqamuzana egazi abomvu amaningi. I-EPO yenziwa ngamaseli ezinso. Lawa maseli akhipha ama-EPO amaningi lapho izinga le-oxygen yegazi liphansi.

Kudingeka isampula yegazi.

Akukho ukulungiselela okukhethekile okudingekayo.

Lapho inaliti ifakwa ukudonsa igazi, abanye abantu bezwa ubuhlungu obulinganiselayo. Abanye bazizwa behlatshwa noma bezwa nje kuphela. Ngemuva kwalokho, kungahle kube nokushaywa okuthile.

Lokhu kuhlolwa kungasetshenziselwa ukusiza ukuthola imbangela yokushoda kwegazi, i-polycythemia (ukubala okuphezulu kwamaseli egazi) noma okunye ukuphazamiseka kwemnkantsha.

Ukuguqulwa kwamaseli abomvu wegazi kuzothinta ukukhishwa kwe-EPO. Isibonelo, abantu abane-anemia banamaseli abomvu ambalwa kakhulu, ngakho-ke kukhiqizwa i-EPO eningi.

Ububanzi obujwayelekile bungu-2.6 kuya ku-18.5 milliunits ngemililitha ngayinye (mU / mL).

Izibonelo ezingenhla yizilinganiso ezijwayelekile zemiphumela yalezi zivivinyo. Ububanzi bamanani ajwayelekile bungahluka kancane phakathi kwamalabhorethri ahlukene. Amanye amalebhu asebenzisa izilinganiso ezahlukahlukene noma avivinye amasampula ahlukile. Khuluma nomhlinzeki wakho wezokunakekelwa kwempilo mayelana nencazelo yomphumela wakho wokuhlolwa okhethekile.

Izinga le-EPO elandisiwe lingahle libe ngenxa ye-polycythemia yesibili. Lokhu ukukhiqizwa ngokweqile kwamaseli abomvu egazi okwenzeka ngokuphendula umcimbi onjengezinga eliphansi le-oxygen yegazi. Isimo singenzeka ezindaweni eziphakeme kakhulu noma, kuyaqabukela, ngenxa yesimila esikhipha i-EPO.

Izinga le-EPO elingaphansi kokujwayelekile lingabonakala ekuhlulekeni okungapheli kwezinso, i-anemia yezifo ezingamahlalakhona, noma i-polycythemia vera.

Izingozi ezihambisana nokudonswa igazi zincane, kepha zingafaka:

• Ukopha ngokweqile
• Ukuquleka noma uzizwe unekhanda elincane
• I-hematoma (ukuqoqwa kwegazi ngaphansi kwesikhumba)
• Ukutheleleka (ingozi encane noma kunini lapho isikhumba siphukile)

Serum erythropoietin; EPO

I-Bain BJ. I-peripheral blood smear. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 148.

I-Kaushansky K. Hematopoiesis nezici zokukhula kwe-hematopoietic. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 147.

UKremyanskaya M, Najfeld V, Mascarenhas J, Hoffman R.I-polycythemias. Ku: Hoffman R, Benz EJ, Silberstein LE, et al, ama-eds. I-Hematology: Izimiso Eziyisisekelo Nokuzijwayeza. Umhla wesi-7. IPhiladelphia, PA: Elsevier Saunders; 2018: isahluko 68.

UKumar V, Abbas AK, Aster JC. Iseli elibomvu legazi nokuphazamiseka kokopha. Ku: Kumar P, Clark M, ama-eds. Imitholampilo kaKumar noClarke. Umhlaka 9. IPhiladelphia, PA: Elsevier; I-2017: isahluko 14.