Ukuhlolwa komchamo weCortisol

Ukuhlolwa komchamo we-cortisol kukala izinga le-cortisol emchameni. ICortisol iyi-hormone ye-glucocorticoid (steroid) ekhiqizwa yi-adrenal gland.

ICortisol nayo ingalinganiswa kusetshenziswa ukuhlolwa kwegazi noma kwamathe.

Kudingeka isampula yamahora angama-24. Uzodinga ukuqoqa umchamo wakho ngaphezu kwamahora angama-24 esitsheni esihlinzekwe ilebhu. Umhlinzeki wakho wezempilo uzokutshela ukuthi ungakwenza kanjani lokhu. Landela imiyalo ngqo.

Ngoba ukukhiqizwa kwe-cortisol yi-adrenal gland kungahluka, ukuhlolwa kungadinga ukwenziwa izikhathi ezintathu noma ngaphezulu ezihlukene ukuthola isithombe esinembe kakhudlwana sokukhiqizwa kwe-cortisol okujwayelekile.

Ungacelwa ukuthi ungenzi noma ikuphi ukuzivocavoca ngamandla ngosuku olwandulela ukuhlolwa.

Ungatshelwa futhi ukuthi uyeke ukuthatha imishanguzo okwesikhashana okungathinta ukuhlolwa, kufaka phakathi:

• Izidakamizwa ezilwa nokuquleka
• I-Estrogen
• I-glucocorticoids eyenziwe ngabantu (i-hydrocortisone, i-prednisone ne-prednisolone)
• I-Androgens

Ukuhlolwa kuhilela ukuchama okuvamile kuphela. Akukho ukungakhululeki.

Isivivinyo senziwa ukuhlola ukukhiqizwa kwe-cortisol okwandisiwe noma okunciphile. ICortisol iyi-hormone ye-glucocorticoid (steroid) ekhishwe kwi-adrenal gland ekuphenduleni i-adrenocorticotropic hormone (ACTH). Le yihomoni ekhishwe endlaleni yobuchopho ebuchosheni. ICortisol ithinta izinhlelo eziningi ezahlukene zomzimba. Idlala indima ku:

• Ukukhula kwamathambo
• Ukulawulwa kwengcindezi yegazi
• Umsebenzi wesistimu yomzimba
• I-metabolism yamafutha, ama-carbohydrate, namaprotheni
• Ukusebenza kwesistimu yezinzwa
• Impendulo yengcindezi

Izifo ezahlukahlukene, ezinjenge-Cushing syndrome nesifo i-Addison, zingaholela ekukhiqizeni kakhulu noma okuncane kakhulu kwe-cortisol. Ukukala izinga lomchamo we-cortisol kungasiza ukuxilonga lezi zimo.

Ibanga elijwayelekile ngama-4 kuye kuma-40 mcg / amahora angama-24 noma i-11 kuye ku-110 nmol / ngosuku.

Ububanzi bamanani ajwayelekile bungahluka kancane phakathi kwamalabhorethri ahlukene. Amanye amalebhu asebenzisa izilinganiso ezahlukahlukene noma angahlola izinhlobo ezihlukile. Khuluma nomhlinzeki wakho mayelana nencazelo yemiphumela yakho ethile yokuhlolwa.

Izinga eliphakeme kunokujwayelekile lingaveza:

• Isifo se-Cushing, lapho i-pituitary gland yenza i-ACTH eningi kakhulu ngenxa yokukhula okweqile kwendlala ye-pituitary noma isimila endleni ye-pituitary
• I-Ectopic Cushing syndrome, lapho isimila esingaphandle kwezindlala zepituitary noma i-adrenal senza i-ACTH eningi kakhulu
• Ukucindezeleka okukhulu
• Isigaxa se-adrenal gland esikhiqiza i-cortisol eningi kakhulu
• Ukucindezeleka okukhulu
• Izinkinga ezivamile zofuzo

Izinga eliphansi kunokujwayelekile lingaveza:

• Isifo i-Addison lapho izindlala ze-adrenal zingakhiqizi i-cortisol eyanele
• I-Hypopituitarism lapho i-pituitary gland ingakhombisi ukuthi i-adrenal gland ikhiqiza i-cortisol eyanele
• Ukucindezelwa komsebenzi ojwayelekile wesibeletho noma we-adrenal ngemithi ye-glucocorticoid kufaka phakathi amaphilisi, okhilimu besikhumba, ama-eyedrops, ama-inhalers, imijovo ehlangene, i-chemotherapy

Azikho izingozi ngalokhu kuhlolwa.

I-cortisol yamahhala yamahora angama-24 (UFC)

• Umgudu womchamo wabesifazane
• Umgudu womchamo wabesilisa

IChernecky CC, iBerger BJ. ICortisol - umchamo. Ku: IChernecky CC, iBerger BJ, ama-eds. Ukuhlolwa Kwelabhoratri Nezinqubo Zokuxilonga. Umhlaka 6. ISt Louis, MO: Elsevier Saunders; 2013: 389-390.

UStewart PM, iNewell-Price JDC. I-adrenal cortex. Ku: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, abahleli. Incwadi kaWilliams ye-Endocrinology. Umhlaka 13. IPhiladelphia, PA: Elsevier; 2016: isahluko 15.