Izinga le-Vitamin B12

Izinga likavithamini B12 ukuhlolwa kwegazi okulinganisa ukuthi uvithamini B12 ongakanani osegazini lakho.

Kudingeka isampula yegazi.

Akufanele udle noma uphuze amahora angaba yisithupha kuya kwayisishiyagalombili ngaphambi kokuhlolwa.

Imithi ethile ingathinta imiphumela yalokhu kuhlolwa. Umhlinzeki wakho wokunakekelwa kwezempilo uzokutshela uma udinga ukuyeka ukusebenzisa noma imiphi imithi. UNGAYIMISI noma imuphi umuthi ngaphambi kokukhuluma nomhlinzeki wakho.

Imithi engathinta imiphumela yokuhlolwa ifaka phakathi:

• I-Colchicine
• I-Neomycin
• I-Para-aminosalicylic acid
• Phenytoin

Lapho inaliti ifakwa ukudonsa igazi, abanye abantu bezwa ubuhlungu obulinganiselayo. Abanye bazizwa beshaywa noma betinyelwa kuphela. Ngemuva kwalokho, kungahle kube nokushaywa okuthile noma ukulimazeka okuncane. Lokhu maduzane kuyaphela.

Lokhu kuhlolwa kuvame ukwenziwa lapho okunye ukuhlolwa kwegazi kusikisela isimo okuthiwa i-megaloblastic anemia. I-anemia ekhathazayo iyindlela ye-megaloblastic anemia ebangelwa ukumuncwa kwe-vitamin B12. Lokhu kungenzeka lapho isisu senza into encane umzimba odinga ukumunca kahle uvithamini B12.

Umhlinzeki wakho futhi angancoma ukuhlolwa kukavithamini B12 uma unezimpawu ezithile zesistimu yezinzwa. Izinga eliphansi le-B12 lingadala ukuba ndikindiki noma ukuhayiza ezingalweni nasemilenzeni, ubuthakathaka, nokulahlekelwa ibhalansi.

Ezinye izimo okungenziwa ukuhlolwa kuzo zifaka:

• Ukudideka okukhulu okungazelelwe (delirium)
• Ukulahleka kokusebenza kobuchopho (ukuwohloka komqondo)
• Ukuwohloka komqondo ngenxa yezimbangela ze-metabolic
• Ukungajwayelekile kwemizwa, njenge-peripheral neuropathy

Amanani ajwayelekile angama-picograms ayi-160 kuya kwayi-950 ngemililitha (pg / mL), noma ama-picomoles ayi-118 kuye kwangama-701 ngelitha ngalinye (pmol / L).

Ububanzi bamanani ajwayelekile bungahluka kancane phakathi kwamalabhorethri ahlukene. Amanye amalebhu asebenzisa izilinganiso ezahlukahlukene noma angahlola amasampula ahlukile. Khuluma nomhlinzeki wakho mayelana nokuthi imiphumela yakho ethile yokuhlolwa isho ukuthini.

Amanani angaphansi kuka-160 pg / mL (118 pmol / L) ayizimpawu zokushoda kukavithamini B12. Abantu abanale nkinga kungenzeka babe noma bahlakulele izimpawu.

Abantu abadala asebekhulile abanevithamini B12 elingaphansi kuka-100 pg / mL (74 pmol / L) nabo bangaba nezimpawu. Ukushoda kufanele kuqinisekiswe ngokuhlola izinga lezinto ezisegazini elibizwa ngokuthi i-methylmalonic acid. Izinga eliphakeme likhombisa ukuntuleka kweqiniso kwe-B12.

Izimbangela zokushoda kukavithamini B12 zifaka:

• Ayanele i-vitamin B12 ekudleni (okungajwayelekile, ngaphandle kokudla okuqinile kwemifino)
• Izifo ezibanga i-malabsorption (isibonelo, isifo se-celiac nesifo se-Crohn)
• Ukuntuleka kwesici esingaphakathi, iphrotheni esiza amathumbu ukuthi amunce uvithamini B12
• Ngaphezulu kokukhiqizwa kokushisa okujwayelekile (ngokwesibonelo, nge-hyperthyroidism)
• Ukukhulelwa

Izinga lenyuka levithamini B12 alijwayelekile. Imvamisa, i-vitamin B12 eyeqile iyasuswa emchameni.

Izimo ezingakhuphula izinga le-B12 zifaka:

• Isifo sesibindi (njenge-cirrhosis noma i-hepatitis)
• Izinkinga ze-Myeloproliferative (ngokwesibonelo, i-polycythemia vera ne-leukemia engapheli emithambo yegazi)

Kunengozi encane ethintekayo ekuthatheni igazi lakho. Imithambo nemithambo yegazi kuyahluka ngosayizi komunye umuntu kuya kolunye uhlangothi lomzimba kuya kolunye. Ukuthatha igazi kwabanye abantu kungaba nzima kakhulu ukwedlula kwabanye.

Ezinye izingozi ezihambisana nokudonswa igazi zincane, kepha zingafaka:

• Ukopha ngokweqile
• Ukuquleka noma uzizwe unekhanda elincane
• Ukubhoboza okuningi ukuthola imithambo
• I-hematoma (i-blood buildup ngaphansi kwesikhumba)
• Ukutheleleka (ingozi encane noma kunini lapho isikhumba siphukile)

Ukuhlolwa kweCobalamin; I-anemia enamandla - izinga levithamini B12

UMarcogliese AN, Yee DL. Izinsizakusebenza ze-hematologist: ukuphawula okuhunyushiwe kanye namanani ayizethenjwa akhethiwe wezingane ezisanda kuzalwa, ezingane kanye nabantu abadala. Ku: Hoffman R, Benz EJ, Silberstein LE, et al, ama-eds. I-Hematology: Izimiso Eziyisisekelo Nokuzijwayeza. Umhla wesi-7. IPhiladelphia, PA: Elsevier; 2018: isahluko 162.

UMason JB, iBooth SL. Amavithamini, umkhondo wamaminerali, namanye ama-micronutrients. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 205.