Ukufakelwa kabusha kwe-Fecal microbiota

Ukufakelwa kwe-Fecal microbiota (FMT) kusiza ukufaka amanye amabhaktheriya "amabi" ekholoni lakho ngamagciwane "amahle". Inqubo isiza ukubuyisa amabhaktheriya amahle abulewe noma anqunyelwe ukusetshenziswa kwama-antibiotic. Ukubuyisela le bhalansi kukholoni kwenza kube lula ukulwa nokutheleleka.

I-FMT ibandakanya ukuqoqa indle kumnikeli onempilo. Umhlinzeki wakho wokunakekelwa kwezempilo uzokucela ukuthi ukhombe umnikeli. Iningi labantu likhetha ilungu lomndeni noma umngane oseduze. Umnikeli akumele asebenzise ama-antibiotic ezinsukwini ezimbili kuya kwezi-3 ezedlule. Bazohlolelwa noma yikuphi ukutheleleka okusegazini noma kwendle.

Uma sekuqoqiwe, indle yomnikeli ixutshwa namanzi anosawoti bese iyahlungwa. Ingxube yendle ibese idluliselwa kumgudu wakho wokugaya ukudla (ikholoni) ngokusebenzisa ithubhu edlula kwi-colonoscope (ithubhu elincane, eliguquguqukayo elinekhamera encane). Ama-bacteria amahle angaphinde angeniswe emzimbeni ngendlela yeshubhu elingena esiswini ngomlomo. Enye indlela ukugwinya i-capsule equkethe indle yabanikeli abomisiwe.

Amathumbu amakhulu anenani elikhulu lamagciwane. Lawa mabhaktheriya ahlala emathunjini akho abalulekile empilweni yakho, futhi akhula ngendlela elinganiselayo.

Elinye lala magciwane libizwa AmaClostridioides difficile (I-C difficile). Ngamanani amancane, akubangeli izinkinga.

• Kodwa-ke, uma umuntu ethola imithamo ephindaphindiwe noma ephezulu yama-antibiotic yokutheleleka kwenye indawo emzimbeni, amabhaktheriya amaningi ajwayelekile emathunjini angasuswa. Amagciwane akhula futhi akhiphe ubuthi.
• Umphumela ungahle ube ukuthi kuningi kakhulu kwe- C ukwehlukana.
• Le toxin idala ukuthi ulwelwesi lwamathumbu amakhulu luvuvuke futhi luvuvuke, lubangele umkhuhlane, uhudo, nokopha.

Amanye ama-antibiotic kwesinye isikhathi angaletha C ukwehlukana amagciwane alawulwa. Uma lokhu kungaphumeleli, i-FMT isetshenziselwa ukufaka okunye esikhundleni se- C ukwehlukana ngamagciwane "amahle" futhi ubuyisele ibhalansi.

I-FMT nayo ingasetshenziselwa ukwelapha izimo ezinjenge:

• Isifo samathumbu esicasulayo
• Isifo seCrohn
• Ukuqunjelwa
• I-ulcerative colitis

Ukwelashwa kwezimo ngaphandle kokuphindelela C ukwehlukana colitis kubhekwa njengokuhlola okwamanje futhi akusetshenziswa kabanzi noma kwaziwa ukuthi kuyasebenza.

Izingozi ze-FMT zingafaka okulandelayo:

• Ukusabela emithini oyinikezwayo ngenkathi kwenziwa inqubo
• Ukopha okukhulu noma okuqhubekayo ngesikhathi senqubo
• Izinkinga zokuphefumula
• Ukusabalala kwezifo kusuka kumnikeli (uma umnikeli engahloliswanga kahle, okuyinto engajwayelekile)
• Ukutheleleka ngesikhathi se-colonoscopy (okungajwayelekile kakhulu)
• Amahlule egazi (angavamile kakhulu)

Umnikeli kungenzeka athathe i-laxative ngobusuku obandulela inqubo ukuze bakwazi ukunyakaza amathumbu ngakusasa ekuseni. Bazoqoqa isampula lendle enkomishini ehlanzekile bese beletha nalo ngosuku lwenqubo.

Khuluma nomhlinzeki wakho nganoma yikuphi ukungezwani komzimba nayo yonke imithi oyiphuzayo. Ungayeki ukuthatha noma imuphi umuthi ngaphandle kokukhuluma nomhlinzeki wakho. Uzodinga ukuyeka ukuthatha noma yimaphi ama-antibiotic ezinsukwini ezimbili kuya kwezi-3 ngaphambi kwenqubo.

Ungadinga ukulandela ukudla oketshezi. Ungacelwa ukuthi uthathe ama-laxatives ngobusuku obandulela inqubo. Uzodinga ukulungiselela ikholonoscopy ngobusuku obandulela i-FMT. Udokotela wakho uzokunika imiyalo.

Ngaphambi kwenqubo, uzonikezwa imithi ezokukwenza ungalali ukuze ungezwa ukungakhululeki noma ube nenkumbulo yokuhlolwa.

Uzolala ngohlangothi lwakho cishe amahora amabili ngemuva kwenqubo enesisombululo emathunjini akho. Unganikezwa i-loperamide (Imodium) ukusiza ukubambezela izibilini zakho ukuze isisombululo sihlale sikhona ngalesi sikhathi.

Uzobuyela ekhaya ngalo lolo suku lwenqubo uma usudlulise ingxube yezihlalo. Uzodinga ukugibela uye ekhaya, ngakho-ke qiniseka ukuthi ukuhlelela ngaphambi kwesikhathi. Kufanele ugweme ukushayela, ukuphuza utshwala, noma yikuphi ukuphakamisa okunzima.

Ungaba nomkhuhlane osezingeni eliphansi ngobusuku obalandela inqubo. Ungaba nokuqunjelwa, igesi, ukuqumba, nokuqunjelwa izinsuku ezimbalwa ngemuva kwenqubo.

Umhlinzeki wakho uzokuyalela ngohlobo lokudla nemithi okudingeka uyithathe ngemuva kwenqubo.

Lokhu kwelashwa okusindisa impilo kuphephe kakhulu, kuyasebenza futhi kubiza kancane. I-FMT isiza ngokubuyisa izimbali ezijwayelekile ngesitokisi sabanikeli. Lokhu nakho kusiza ekutholeni ukusebenza kwamathumbu akho okujwayelekile kanye nempilo.

I-fecal bacteriotherapy; Ukufakelwa kwesihlalo; Ukufakelwa kabusha kwe-Fecal; C. difficile colitis - ukufakelwa indle; I-Clostridium difficile - ukufakelwa kwe-fecal; I-Clostridioides difficile - ukufakelwa kwe-fecal; Pseudomembranous colitis - ukufakelwa indle

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USchneider A, uMaric L. Fecal ukufakelwa kwe-microbiota njengokwelashwa kwesifo samathumbu esivuthayo. Ku: Shen B, ed. Izifo Zamathumbu Okungenelela. ISan Diego, CA: I-Elsevier Academic Press; 2018: isahluko 28.

ISurawicz CM, uBrandt LJ. Ama-Probiotic kanye nokufakelwa kabusha kwe-fecal microbiota. Ku: Feldman M, Friedman LS, Brandt LJ, ama-eds. ISleisenger neFordtran's Gastrointestinal and Liver Disease: IPathophysiology / Diagnosis / Management. Umhlaka 10. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 130.