I-Sodium Oxybate

-Delile

• Ukuze ulungiselele amanani we-sodium oxybate, landela lezi zinyathelo:
• Ngaphambi kokuthatha i-sodium oxybate,
• I-sodium oxybate ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Lezi zimpawu ezilandelayo azivamile, kepha uma uhlangabezana nenye yazo noma leyo ebhalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-sodium oxybate elinye igama le-GHB, into evame ukuthengiswa ngokungemthetho futhi ihlukunyezwe, ikakhulukazi ngabantu abadala ezindaweni zokuxhumana njengama-nightclub. Tshela udokotela wakho uma usebenzisa noma wake wasebenzisa izidakamizwa zasemgwaqweni, noma uma usebenzise ngokweqile imithi kadokotela. I-oxybate ye-sodium ingaba yingozi uma ithathwa ngabantu okungewona lowo muntu ebinikezwe yona. Ungathengisi noma unikeze i-oxybate yakho ye-sodium kunoma ngubani omunye umuntu; ukuthengisa noma ukuwabelana nabanye kuphambene nomthetho. Gcina umoya we-sodium endaweni ephephile, njengekhabethe elikhiyiwe noma ibhokisi, ukuze kungabikho omunye umuntu ongayithatha ngephutha noma ngenhloso. Gcina umkhondo wokuthi kungakanani uketshezi olusele ebhodleleni lakho ukuze wazi ukuthi kukhona okushodayo.

I-sodium oxybate ingadala imiphumela emibi kakhulu, kufaka phakathi izinkinga zokuphefumula ezinzima noma ezisongela impilo. Tshela udokotela wakho uma uphuza amaphilisi okulala. Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-sodium oxybate ngenkathi uthatha lo muthi. Futhi, tshela udokotela wakho uma uphuza imishanguzo yokudambisa imishanguzo; i-benzodiazepines efana ne-alprazolam (i-Xanax), i-chlordiazepoxide (i-Librium), i-clonazepam (i-Klonopin), i-diazepam (i-Diastat, i-Valium), i-estazolam, i-flurazepam, i-lorazepam (i-Ativan), i-oxazepam, i-temazepam (i-Restoril) ne-triazol imithi yokugula kwengqondo, isicanucanu, noma ukuquleka; ukuphumula kwemisipha; noma imithi yezinhlungu ze-narcotic. Udokotela wakho kungadingeka ukuthi ushintshe imithamo yemithi yakho futhi akuhlole ngokucophelela. Ungaphuzi iziphuzo ezidakayo ngenkathi uthatha i-sodium oxybate.

I-sodium oxbate ayitholakali ezikhemisi ezidayisa izinto ezidayiswayo. I-sodium oxbate itholakala kuphela ngohlelo lokusabalalisa olukhawulelwe olubizwa nge-Xywav neXyrem REMS Program. Kuluhlelo olukhethekile lokusabalalisa imishanguzo nokunikeza imininingwane ngemithi. Imithi yakho izothunyelwa kuwe ngeposi ekhemisi emaphakathi ngemuva kokufunda imininingwane futhi wakhuluma nosokhemisi. Buza udokotela wakho uma unemibuzo mayelana nokuthi uzowuthola kanjani umuthi wakho.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-sodium oxybate futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungathola futhi iMihlahlandlela Yezokwelapha kwiwebhusayithi ye-FDA: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm.

Gcina wonke ama-aphoyintimenti nodokotela wakho.

Khuluma nodokotela wakho ngezingozi zokuthatha i-sodium oxybate.

I-oxybate ye-sodium isetshenziselwa ukuvimbela ukuhlaselwa kwe-cataplexy (iziqephu zobuthakathaka bemisipha eziqala ngokuzumayo futhi zihlale isikhashana) nokulala ngokweqile emini kubantu abadala nezingane ezineminyaka engu-7 nangaphezulu abane-narcolepsy (ukuphazamiseka kokulala okungadala ubuthongo obukhulu , ukulangazelela okungalawuleki okungazelelwe kokulala ngesikhathi semisebenzi yansuku zonke, kanye ne-cataplexy).I-sodium oxbate isesigabeni semithi ebizwa ngokuthi i-central nervous system depressants. I-sodium oxybate isebenza ukwelapha i-narcolepsy kanye ne-cataplexy ngokunciphisa ukusebenza ebuchosheni.

I-sodium oxbate iza njengesisombululo (uketshezi) sokuxubana namanzi uthathe ngomlomo. Imvamisa ithathwa kabili ubusuku ngabunye ngoba i-sodium oxybate iyaphela ngemuva kwesikhashana, futhi imiphumela yedosi eyodwa ngeke ihlale ubusuku bonke. Umthamo wokuqala uthathwa ngesikhathi sokulala, kanti umthamo wesibili uthathwa emahoreni ama-2 1/2 kuya kwangu-4 ngemuva komthamo wokuqala. I-oxybate ye-sodium kufanele iphuzwe esiswini esingenalutho, ngakho-ke umthamo wokuqala kufanele uphuzwe okungenani amahora amabili ngemuva kokudla. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi.

Ungathathi imithamo yakho yokulala ngesikhathi se-sodium oxybate kuze kube yilapho wena noma ingane yakho nisembhedeni futhi nilungele ukulala ebusuku. I-sodium oxybate iqala ukusebenza ngokushesha okukhulu, kungakapheli imizuzu emihlanu kuya kwengu-15 ngemuva kokuyithatha. Beka umthamo wakho wesibili we-sodium oxybate endaweni ephephile eduze kombhede wakho (noma endaweni ephephile ongayinikeza ingane yakho) ngaphambi kokulala. Sebenzisa iwashi le-alamu ukuze uqiniseke ukuthi uzovuka ngesikhathi ukuze uthathe umthamo wesibili. Uma wena noma ingane yakho uvuka ngaphambi kokuba i-alamu icishe futhi kube okungenani amahora amabili nesigamu selokhu uthathe umthamo wakho wokuqala, thatha umthamo wakho wesibili, cisha i-alamu, bese ubuyela ekulaleni.

Udokotela wakho mhlawumbe uzokuqala ngomthamo ophansi we-sodium oxybate futhi kancane kancane akhuphule umthamo wakho, hhayi kaningi ngaphezu kwesisodwa njalo ngesonto.

I-sodium oxybate ingaba umkhuba wokwakha. Ungayithathi ngaphezulu noma uyithathe kaningi kunokuyalelwa ngudokotela wakho. Uma uthatha i-oxybate eningi kakhulu ye-sodium, ungahlangabezana nezimpawu ezisongela impilo kufaka phakathi ukuquleka, ukubambezela noma ukumisa ukuphefumula, ukulahlekelwa ukwazi, nokuquleka. Ungase futhi uhlakulele ukulangazelela i-sodium oxybate, uzizwe unesidingo sokuthatha imithamo emikhulu futhi emikhulu, noma ufune ukuqhubeka nokuthatha i-sodium oxybate yize ibangela izimpawu ezingathandeki. Uma uthathe i-oxybate ye-sodium ngamanani amakhulu kunokuyalelwa ngudokotela wakho, futhi ngokungazelelwe uyeke ukuwuthatha, ungahle uhlangabezane nezimpawu zokuhoxa njengobunzima bokulala noma ukulala, ukungahlaliseki, ukukhathazeka, ukucabanga okungavamile, ukulahlekelwa ukuxhumana neqiniso, ukulala , ukucasula isisu, ukuqhaqhazela ingxenye ethile yomzimba ongakwazi ukuyilawula, ukujuluka, ukuqunjelwa yimisipha nokushaya kwenhliziyo okusheshayo.

I-sodium oxybate ingasiza ukulawula izimpawu zakho kepha ngeke iselaphe isimo sakho. Qhubeka uthathe i-oxybate ye-sodium noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-sodium oxybate ngaphandle kokukhuluma nodokotela wakho. Udokotela wakho mhlawumbe uzofuna ukwehlisa umthamo wakho kancane kancane. Uma ngokungazelelwe uyeka ukuthatha i-sodium oxybate, ungahle ube nokuhlaselwa okuningi kwe-cataplexy futhi ungathola ukukhathazeka nobunzima bokulala noma ukulala.

Ukuze ulungiselele amanani we-sodium oxybate, landela lezi zinyathelo:

1. Vula ibhokisi lapho umuthi wakho ungene futhi ususe ibhodlela lomuthi kanye nedivayisi yokulinganisa.
2. Susa idivaysi yokulinganisa ku-wrapper yayo.
3. Vula ibhodlela ngokucindezela phansi kukepisi bese ujikisa ikepisi ngokungqubeka kwewashi (ngakwesokunxele) ngasikhathi sinye.
4. Beka ibhodlela elivulekile limile etafuleni.
5. Bamba ibhodlela limile ngesandla esisodwa. Sebenzisa esinye isandla sakho ukubeka ithiphu yedivayisi yokulinganisa ekuvuleni kwesikhungo phezulu kwebhodlela. Cindezela ithiphu ngokuqinile ekuvuleni.
6. Bamba ibhodlela nokokulinganisa ngesandla esisodwa. Sebenzisa esinye isandla sakho ukubuyela emuva ku-plunger kuze kube ngisho nangokumaka okufana nomthamo kadokotela wakho. Qiniseka ukuthi ugcina ibhodlela limile ukuvumela umuthi ukuba ugelezele kudivayisi yokulinganisa.
7. Susa insimbi yokulinganisa ngaphezulu kwebhodlela. Beka ithiphu yedivayisi yokulinganisa kwenye yezinkomishi zokulinganisa ezinikezwe umuthi.
8. Cindezela phansi ku-plunger ukukhipha umuthi enkomishini yokufaka imithamo.
9. Faka ama-ounces ama-2 (60 milliliters, 1/4 inkomishi, noma izipuni ezingaba ngu-4) zamanzi ompompi enkomishini yokulinganisa. Imithi izonambitheka kangcono uma uyixube namanzi abandayo. Ingabe hhayi hlanganisa umuthi nejusi yezithelo, iziphuzo ezibandayo, noma olunye uketshezi.
10. Phinda izinyathelo 5 kuya ku-9 ukulungisa umthamo we-sodium oxybate enkomishini yesibili yokulinganisa.
11. Beka amakepisi kuzo zombili izinkomishi zokulinganisa Jikela ikepisi ngalinye ngokwewashi (ngakwesokudla) lize lichofoze likhiye endaweni.
12. Hlanza insimbi yokulinganisa ngamanzi.
13. Faka ikepisi ebhodleleni le-sodium oxbate bese ubuyisela ibhodlela nokukala endaweni ephephile lapho kugcinwa khona kude nezingane nezilwane ezifuywayo. Beka zombili izinkomishi zemithi ezilungiselelwe endaweni ephephile eseduze kombhede wakho noma endaweni ephephile ukuze unikeze ingane yakho lapho kungafinyeleleki khona ezinganeni nasezifuyweni.
14. Uma sekuyisikhathi sokuthi uthathe umthamo wokuqala we-sodium oxybate, cindezela phansi ikepisi bese uliphendula ngokungahambisani newashi (ngakwesokunxele). Phuza lonke uketshezi ngenkathi uhleli embhedeni wakho. Beka ikepisi emuva enkomishini, uyiphendukise ngokwewashi (kwesokudla) ukuyikhiya endaweni, bese ulala phansi khona lapho.
15. Uma uvuka amahora ama-2/2 kuya kwangu-4 kamuva ukuthatha umthamo wesibili, phinda isinyathelo 14.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-sodium oxybate,

• Tshela udokotela wakho kanye nosokhemisi uma une-aleji ku-sodium oxybate, noma imiphi eminye imishanguzo, noma ezinye izithako ezisesixazululo se-sodium oxybate. Buza usokhemisi wakho noma hlola umhlahlandlela wemithi ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo. Qiniseka ukusho okulandelayo: divalproex (Depakote). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma uke waba nokushoda okuncane kwe-semialdehyde dehydrogenase (isimo esizuzwe njengefa lapho izinto ezithile zakha khona emzimbeni futhi zidale ukubambezeleka nokubambezeleka kokuthuthuka). Udokotela wakho uzokutshela ukuthi ungathathi i-sodium oxybate.
• Tshela udokotela wakho uma ulandela ukudla okunosawoti omncane ngezizathu zokwelashwa. Tshela nodokotela wakho uma uhona; uma uke wacabanga ngokuzilimaza noma ukuzibulala noma uhlele noma uzame ukwenza kanjalo; futhi uma uke waba nesifo samaphaphu noma waba nesifo samaphaphu, ukuphefumula kanzima, i-apnea yokulala (inkinga yokulala ebangela ukuphefumula ukuma isikhashana ngesikhathi sokulala), ukuqubuka, ukudangala noma okunye ukugula kwengqondo, ukwehluleka kwenhliziyo, umfutho wegazi ophakeme, noma isibindi noma isifo sezinso.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-sodium oxybate, shayela udokotela wakho.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-sodium oxybate.
• kufanele wazi ukuthi uzolala kakhulu okungenani amahora awu-6 ngemuva kokuthatha i-sodium oxybate, futhi ungazuma nasemini. Ungashayeli imoto, sebenzisa imishini, undize indiza, noma wenze noma imiphi eminye imisebenzi eyingozi okungenani amahora ayisithupha ngemuva kokuthatha umuthi wakho. Gwema imisebenzi eyingozi ngaso sonke isikhathi uze wazi ukuthi i-sodium oxybate ikuthinta kanjani.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa umthamo wesibili we-sodium oxybate, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yobusuku obulandelayo. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile. Njalo vumela okungenani amahora angu-2/2 phakathi kwamanani we-sodium oxybate.

I-sodium oxybate ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukufafaza umbhede
• ikhanda
• isiyezi
• ngizizwe ngidakiwe
• ukuzamazama kwengxenye yomzimba wakho ongeke ukwazi ukuyilawula
• imizwa yokuba ndikindiki, ukuhayiza, ukubhoboza, ukushisa, noma ukukhasa esikhunjeni
• ubunzima bokuhamba lapho ulele noma uvuka
• isicanucanu
• ukuhlanza
• isifo sohudo
• ubuhlungu besisu
• ukuhlungu obusemhlane
• ubuthakathaka
• ukuvuvukala kwezingalo, izandla, izinyawo, amaqakala, noma imilenze engezansi
• ukujuluka

Eminye imiphumela emibi ingaba mibi. Lezi zimpawu ezilandelayo azivamile, kepha uma uhlangabezana nenye yazo noma leyo ebhalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukulala
• amaphupho angajwayelekile
• ukuyaluza
• ulaka
• ukukhathazeka
• ukudana
• ukudideka noma izinkinga zememori
• ushintsho kusisindo noma isifiso sokudla
• imizwa yecala
• imicabango yokuzilimaza noma ukuzibulala
• ukuzwa ukuthi abanye bafuna ukukulimaza
• ukusangana (ukubona izinto noma ukuzwa amazwi angekho)
• ukulahlekelwa ukuxhumana neqiniso
• izinkinga zokuphefumula, ukuhogela noma ukuphefumula ubuthongo
• ukozela ngokweqile emini

I-sodium oxbate ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivaliwe ngokuqinile, futhi lapho izingane nezilwane ezifuywayo zingafinyeleli khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Thela noma imuphi umuthi osele phansi kusinki uma kungaphezu kwamahora angama-24 ngemuva kokulungiswa. Sika ilebula ebhodleleni ngomaka bese ulahla ibhodlela elingenalutho kudoti. Buza udokotela wakho noma ushayele ikhemisi eliphakathi nendawo uma unemibuzo ngokulahlwa okufanele kwemithi yakho uma kuphelelwe yisikhathi noma kungasadingeki.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ukudideka
• izinkinga ngokuxhumanisa
• ukuyaluza
• ukulahlekelwa ukwazi
• ikhoma
• ukuphefumula kancane, okungajulile, noma okuphazamisekile
• ukulahlekelwa ukulawula isinye
• ukulahlekelwa kwamathumbu
• ukuhlanza
• ukujuluka
• ikhanda
• ukungaboni kahle
• izihlunu zemisipha noma ukujija
• ukudlikiza
• ukushaya kwenhliziyo okuhamba kancane
• izinga lokushisa lomzimba eliphansi
• imisipha ebuthakathaka

Buza udokotela wakho noma ushayele ikhemisi eliphakathi uma unemibuzo mayelana nokugcwalisa imishanguzo yakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Xyrem^®

• I-Sodium ye-Gamma Hydroxybutyrate
• I-GBH Sodium
• I-GHB Sodium
• I-Oxybate Sodium