Umlobi: Marcus Baldwin
Usuku Lokudalwa: 18 Ujuni 2021
Ukuvuselela Usuku: 19 Unovemba 2024
Anonim
Posaconazole (Non Inferiority Trial) vs Voriconazole in Invasive Aspergillosis
Ividiyo: Posaconazole (Non Inferiority Trial) vs Voriconazole in Invasive Aspergillosis

-Delile

Amaphilisi wokukhishwa okubambezelekile we-Posaconazole nokumiswa ngomlomo kusetshenziselwa ukuvikela ukutheleleka okunzima kwamafungal kubantu abadala nasebusheni abaneminyaka engu-13 nangaphezulu abanekhono elibuthakathaka lokulwa nokutheleleka. Ukumiswa ngomlomo kwePosaconazole kuphinde kusetshenziselwe ukwelapha ukutheleleka ngemvubelo emlonyeni nasemphinjeni kufaka phakathi ukutheleleka ngemvubelo okungenakulashwa ngempumelelo ngeminye imithi. I-Posaconazole isekilasini lemithi ebizwa ngama-azole antifungals. Isebenza ngokunciphisa ukukhula kwesikhunta okubangela ukutheleleka.

I-Posaconazole iza njengokumiswa ngomlomo (uketshezi) nanjengokukhishwa okulibazisekile (kukhipha umuthi emathunjini ukuvikela ukuwohloka kwemithi ngesisu esidi) ithebhulethi ezothathwa ngomlomo. Amathebulethi akhiphe ukubambezeleka avame ukuthathwa nokudla kabili ngosuku ngosuku lokuqala bese kuthi kanye ngosuku. Ukumiswa ngomlomo kuvame ukuthathwa kathathu ngosuku ngokudla okugcwele noma kungakapheli imizuzu engama-20 ngemuva kokudla. Uma ungakwazi ukuthatha ukumiswa ngomlomo ngokudla okugcwele, kuthathe ngesithasiselo esinomsoco oketshezi noma isiphuzo esine-acid esenziwe nge-carbonated njenge-ginger ale. Udokotela wakho uzonquma ukuthi udinga ukusebenzisa isikhathi esingakanani lo muthi. Thatha i-posaconazole ngezikhathi ezifanayo nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-posaconazole njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.


Shake ukumiswa ngomlomo kahle ngaphambi kokusebenzisa ngakunye ukuxuba umuthi ngokulinganayo.

Njalo sebenzisa isipuni sokulinganisa okuza nokumiswa komlomo kwe-posaconazole ukukala umthamo wakho. Ungahle ungatholi inani elifanele lemithi uma usebenzisa isipuni sasekhaya ukukala umthamo wakho. Isipuni kufanele sihlanzwe kahle ngamanzi ngemuva kokusetshenziswa ngakunye nangaphambi kokugcina.

Gwinya amathebulethi okuphuza ukubambezeleka we-posaconazole ephelele; ungawahlukanisi, ungawahlafune noma uwagxoze. Uma ungeke ukwazi ukuwagwinya wonke amaphilisi wokukhishwa okubambezeleke, tshela udokotela wakho.

Umkhiqizo ngamunye we-posaconazole ukhipha umuthi ngokuhlukile emzimbeni wakho futhi awunakusetshenziswa ngokungafani.Thatha kuphela umkhiqizo we-posaconazole obekwe udokotela wakho futhi ungashintsheli komunye umkhiqizo we-posaconazole ngaphandle kokuthi udokotela wakho athi kufanele.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.


Ngaphambi kokuthatha i-posaconazole,

  • Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-posaconazole; eminye imishanguzo efana ne-fluconazole (Diflucan), isavuconazonium (Cresemba), itraconazole (Onmel, Sporanox), ketoconazole (Extina, Nizoral, Xolegel), noma i-voriconazole (Vfend); i-simethicone; noma imiphi eminye imithi; noma yiziphi izithako kumikhiqizo ye-posaconazole. Buza usokhemisi wakho ukuthola uhlu lwezithako.
  • Tshela udokotela wakho uma uthatha noma imiphi yale mithi elandelayo: i-atorvastatin (Lipitor, eCaduet), imithi yohlobo lwe-ergot efana ne-bromocriptine (i-Cycloset, i-Parlodel), i-cabergoline, i-dihydroergotamine (i-DHE 45, i-Migranal), i-ergoloid mesylates (i-Hydergine), i-ergonovine , i-ergotamine (i-Ergomar, eCafergot, eMigergot), ne-methylergonovine (Methergine); i-lovastatin (Altoprev, ku-Advicor); ipimozide (i-Orap); i-quinidine (ku-Nuedexta); simvastatin (Zocor, eSimcor, eVytorin); noma i-sirolimus (Rapamune). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-posaconazole uma uthatha eyodwa noma ngaphezulu yale mithi.
  • Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-benzodiazepines efana ne-alprazolam (Xanax), i-diazepam (i-Valium), i-midazolam, ne-triazolam (i-Halcion); ama-calcium channel blocker afana ne-diltiazem (Cardizem, Cartia, Tiazac, abanye), felodipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab CR, Procardia), kanye ne-verapamil (Calan, Covera, Verelan, abanye); i-cyclosporine (Gengraf, Neoral, Sandimmune); i-digoxin (i-Lanoxin); i-efavirenz (iSustiva, e-Atripla); i-erythromycin (E.E.S., ERYC, Erythrocin, abanye), fosamprenavir (Lexiva); i-glipizide (iGlucotrol); i-phenytoin (iDilantin, Phenytek); i-rifabutin (i-Mycobutin); i-ritonavir (i-Norvir) ethathwe ne-atazanavir (Reyataz); tacrolimus (Astagraf, Envarsus XR, Prograf); vinblastine; kanye ne-vincristine (Marquibo Kit). Uma uthatha ukumiswa ngomlomo kwe-posaconazole, phinda utshele udokotela wakho ukuthi uthatha i-cimetidine (Tagamet), i-esomeprazole (Nexium, eVimovo), noma i-metoclopramide (Reglan). Eminye imishanguzo eminingi ingaxhumana ne-posaconazole, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
  • utshele udokotela wakho uma ngabe uke waba nokushaya kwenhliziyo okuhamba kancane noma okungajwayelekile; isikhathi se-QT eside (inkinga yenhliziyo engajwayelekile engadala ukushaya kwenhliziyo okungajwayelekile, ukuquleka, noma ukufa ngokuzuma); izinkinga zokujikeleza kwegazi; amazinga aphansi we-calcium, i-magnesium, noma i-potassium egazini lakho; noma izinso, noma isifo sesibindi.
  • tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-posaconazole, shayela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.


Uma uthatha ukumiswa ngomlomo, thatha isilinganiso esilahlekile ngokushesha nje lapho usikhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

Uma uthatha amaphilisi okukhipha okulibazisekile, thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma kungaphakathi kwamahora ayi-12 wedosi yakho elandelayo, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Posaconazole ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

  • imfiva
  • ikhanda
  • Ukugodola noma ukuqhaqhazela
  • isiyezi
  • ubuthakathaka
  • ukuvuvukala kwezandla, izinyawo, amaqakala, noma imilenze engezansi
  • isifo sohudo
  • ukuhlanza
  • ubuhlungu besisu
  • ukuqunjelwa
  • isilungulela
  • ukuqubuka
  • ukulunywa
  • ubuhlungu emuva noma imisipha
  • izilonda ezindebeni, emlonyeni, noma emphinjeni
  • ubunzima bokulala noma ukulala
  • ukujuluka okwandayo
  • ukuphuma kwamakhala
  • ukukhwehlela
  • Umphimbo obuhlungu

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, shayela udokotela wakho ngokushesha:

  • ukulimaza noma ukopha okungavamile
  • ukukhathala ngokweqile
  • ukungabi namandla
  • ukulahlekelwa isifiso sokudla
  • isicanucanu
  • ubuhlungu engxenyeni engenhla kwesokudla yesisu
  • ukuphuzi kwesikhumba noma kwamehlo
  • izimpawu ezinjengomkhuhlane
  • umchamo omnyama
  • indle ephaphathekile
  • ukushesha, ukushaya ngamandla, noma ukushaya kwenhliziyo okungajwayelekile
  • ukulahlekelwa ngokuzumayo okungazelelwe
  • ukuphelelwa umoya

I-Posaconazole ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Ungafaki ukumiswa okomlomo.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-posaconazole.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho. Uma usenezimpawu zokutheleleka ngemuva kokuqeda ukuthatha i-posaconazole, shayela udokotela wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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