I-Sorafenib

-Delile

• Ngaphambi kokuthatha i-sorafenib,
• I-Sorafenib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Sorafenib isetshenziselwa ukwelapha i-renal cell carcinoma (RCC; uhlobo lomdlavuza oqala ezinso). I-Sorafenib ibuye isetshenziselwe ukwelapha i-hepatocellular carcinoma (uhlobo lomdlavuza wesibindi) ongeke welashwe ngokuhlinzwa nohlobo oluthile lomdlavuza wegilo osabalalele kwezinye izingxenye zomzimba futhi ongakwazi ukwelashwa nge-iodine enemisebe. USorafenib usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo sephrotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunqanda ukusabalala kwamangqamuzana omdlavuza.

ISorafenib iza njengethebhulethi ezothathwa ngomlomo. Kuvame ukuthathwa kabili ngosuku. I-Sorafenib ithathwa ngaphandle kokudla, ihora eli-1 ngaphambi noma amahora amabili ngemuva kokudla. Thatha i-sorafenib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-sorafenib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya amaphilisi wonke ngamanzi. Musa ukuhlukanisa, ukuhlafuna, noma ukuchoboza.

Udokotela wakho anganciphisa umthamo wakho we-sorafenib ngesikhathi sokwelashwa kwakho, noma angakutshela ukuthi uyeke okwesikhashana noma unomphela ukuthatha i-sorafenib isikhathi esithile uma uba nemiphumela emibi. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho nge-sorafenib.

Qhubeka nokuthatha i-sorafenib noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-sorafenib ngaphandle kokukhuluma nodokotela wakho.

ISorafenib ayitholakali ezikhemisi. Ungathola kuphela i-sorafenib ngeposi kusuka ekhemisi ekhethekile. Buza udokotela wakho uma unemibuzo mayelana nokuthola imithi yakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-sorafenib,

• Tshela udokotela kanye nosokhemisi wakho uma une-allergies ku-sorafenib, noma imiphi eminye imishanguzo, noma ezinye izithako kumathebulethi e-sorafenib. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma unomdlavuza wamaphaphu futhi uthola ukwelashwa nge-carboplatin (Paraplatin) kanye ne-paclitaxel (Abraxane, Onxol, Taxol) noma i-gemcitabine (Gemzar) ne-cisplatin (Platinol). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-sorafenib uma unomdlavuza wamaphaphu futhi uthola le mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela noma engabhaliswanga, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: imishanguzo ethile yama-arrhythmias afana ne-amiodarone (Nexterone, Pacerone), dofetilide (Tikosyn), dronedarone (Multaq), procainamide, quinidine (eNuedexta), ne-sotalol (Betapace, Sorine, Sotylize); ama-anticoagulants (ama-thinner egazi) afana ne-warfarin (Coumadin, Jantoven); i-carbamazepine (i-Equetro, iTegretol, iTeril); i-dexamethasone; ibutilide (Corvert); i-irinotecan (iCamptosar); i-neomycin; i-phenobarbital; i-phenytoin (iDilantin, Phenytek); i-rifabutin (i-Mycobutin); noma i-rifampin (i-Rifadin, i-Rimactane). Eminye imishanguzo eminingi ingaxhumana ne-sorafenib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma uke waba nomfutho ophakeme wegazi, izinkinga zokopha, ubuhlungu besifuba, izinkinga zenhliziyo, ukwandiswa kwe-QT (isigqi senhliziyo esingajwayelekile esingaholela ekuphelelweni amandla, ekulahlekelweni ukwazi, ekuqulekeni, noma ekufeni okungazelelwe), amazinga aphansi i-potassium, i-calcium, noma i-magnesium egazini lakho, ukushaya kwenhliziyo okungajwayelekile, ukwehluleka kwenhliziyo, izinkinga zezinso ngaphandle komdlavuza wezinso, noma izinkinga zesibindi ngaphandle komdlavuza wesibindi.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Kuzofanele wenze ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa. Uma ungowesifazane okwaziyo ukukhulelwa, kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho nezinyanga eziyisithupha ngemuva komthamo wakho wokugcina. Uma ungowesilisa nomlingani wesifazane ongakhulelwa, kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho nezinyanga ezi-3 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ukhulelwa ngenkathi uthatha i-sorafenib, shayela udokotela wakho ngokushesha. I-Sorafenib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa noma uhlela ukuncelisa. Akufanele uncelise ibele ngenkathi uthatha i-sorafenib namasonto ama-2 ngemuva komthamo wakho wokugcina.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-sorafenib.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Yeqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa esivamile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Sorafenib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukukhathala
• ubuthakathaka
• ukubomvu kwesikhumba
• ukulahleka kwezinwele
• ukulunywa
• isikhumba esomile noma esikhanyayo
• ukulahlekelwa isifiso sokudla
• ukuqunjelwa
• isifo sohudo
• umlomo owomile
• ukuncipha komzimba
• ubuhlungu obuhlangene
• ukuba ndikindiki, ubuhlungu noma ukuhayiza ezandleni noma ezinyaweni
• ikhanda

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• ukulimaza noma ukopha okungavamile
• izitulo ezimnyama kanye / noma zokulinda
• igazi elibomvu endle
• ukuhlanza okunegazi
• izinto zokuhlanza ezibukeka njengezizathu zekhofi
• imfiva
• ubuhlungu obukhulu besisu
• isicanucanu
• ukuhlanza
• ubuhlungu besifuba
• ukuphelelwa umoya
• isiyezi noma ukuquleka
• ukujuluka okweqile
• ukushesha, ukushaya ngamandla, noma ukushaya kwenhliziyo okungajwayelekile
• ikhanda elibuhlungu ngokuzumayo
• ukudideka
• izinguquko embonweni
• isithuthwane
• ukuqubuka
• ububomvu, ubuhlungu, ukuvuvukala noma amabhamuza ezintendeni zezandla noma ematheni ezinyawo
• ukuqhuma kwesikhumba nokuxebuka
• isifuba
• ukulunywa
• ukubomvu kwesikhumba
• izilonda zomlomo
• umchamo omnyama
• ukuphuzi kwesikhumba noma kwamehlo
• ubuhlungu engxenyeni engenhla kwesokudla yesisu

I-Sorafenib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• isifo sohudo
• ukuqubuka noma ezinye izinkinga zesikhumba

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-sorafenib. Udokotela wakho uzobuye ahlole umfutho wegazi lakho njalo ngesonto phakathi namasonto ayisithupha okuqala okwelashwa kwakho futhi ngezikhathi ezithile lapho kudingeka.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UNexavar^®