I-Temsirolimus

-Delile

• Ngaphambi kokuthatha i-temsirolimus,
• I-Temsirolimus ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka:

I-Temsirolimus isetshenziselwa ukwelapha i-renal cell carcinoma (RCC, uhlobo lomdlavuza oluqala ezinso). UTemsirolimus usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo samaprotheni angajwayelekile atshela amangqamuzana omdlavuza ukuthi ande. Lokhu kungasiza ukunciphisa ukukhula kwezimila.

I-Temsirolimus iza njengesisombululo (uketshezi) okufanele sinikezwe ngokumnika (ukujova kancane emthanjeni) ngaphezu kwemizuzu engama-30 kuye kwangama-60. Ngokuvamile kunikezwa udokotela noma umhlengikazi ehhovisi likadokotela noma esikhungweni sokumnika. I-Temsirolimus ivame ukunikezwa kanye ngesonto.

Ungase ube nezimpawu ezinjengezinyosi, ukuqubuka, ukulunywa, ukuphefumula kanzima noma ukugwinya, ukuvuvukala kobuso, ukuqhuma, noma ubuhlungu besifuba. Tshela udokotela wakho noma omunye umhlinzeki wezokunakekelwa kwezempilo uma uhlangabezana nalezi zimpawu ngenkathi uthola i-temsirolimus. Udokotela wakho angakunikeza eminye imithi ukusiza ukuvimbela noma ukukhulula lezi zimpawu. Udokotela wakho mhlawumbe uzokunika le mithi ngaphambi kokuthola umthamo ngamunye we-temsirolimus.

Ngaphambi kokuthatha i-temsirolimus,

• Tshela udokotela wakho uma uxabana ne-temsirolimus, sirolimus, antihistamines, noma imiphi eminye imithi, i-polysorbate 80, noma ezinye izithako ezisenkambisweni ye-temsirolimus. Buza udokotela wakho uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: ama-anticoagulants (’ama-thinner egazi’) njenge-warfarin (i-Coumadin); imishanguzo ethize yokubulala izinhlungu efana ne-itraconazole (Sporanox); ketoconazole (Nizoral); kanye ne-voriconazole (Vfen); i-clarithromycin (i-Biaxin); i-dexamethasone (i-Decadron); imishanguzo ethile esetshenziselwa ukwelapha i-HIV / AIDS njenge-atazanavir (Reyataz), indinavir (Crixivan), i-nelfinavir (i-Viracept), i-nevirapine (i-Viramune), i-ritonavir (i-Norvir), ne-saquinavir (i-Invirase); imithi ethile yokuquleka efana ne-carbamazepine (i-Equetro, iTegretol), i-phenobarbital (i-Luminal), ne-phenytoin (i-Dilantin, i-Phenytek); imithi yokwehlisa i-cholesterol kanye ne-lipids; nefazodone; i-rifabutin (i-Mycobutin); i-rifampin (Rifadin, Rifamate, Rifiter); i-serotonin re-uptake inhibitors ekhethiwe efana ne-citalopram (Celexa), i-duloxetine (i-Cymbalta), i-escitalopram (i-Lexapro), i-fluoxetine (i-Prozac, i-Sarafem), i-fluvoxamine (i-Luvox), i-paroxetine (i-Paxil), ne-sertraline (i-Zoloft); i-sirolimus (i-Rapamune, i-Rapamycin); i-sunitinib (Sutent); kanye ne-telithromycin (Ketek). Eminye imishanguzo eminingi ingaxhumana ne-temsirolimus, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu. Futhi qiniseka ukuthi utshela udokotela kanye nosokhemisi wakho uma uyeka ukuthatha omunye wemithi ebhalwe ngenhla ngenkathi uthola ukwelashwa nge-temsirolimus.
• utshele udokotela wakho ukuthi yimiphi imikhiqizo yamakhambi oyithathayo, ikakhulukazi iSt John's Wort.
• Tshela udokotela wakho uma uke waba nesifo sikashukela, i-cholesterol ephezulu noma i-triglycerides, isimila esimisweni sezinzwa esiyinhloko (ubuchopho noma umgogodla), umdlavuza, noma izinso, isibindi noma isifo samaphaphu.
• tshela udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa, noma uma uhlela ukuba nobaba wengane. Wena noma umlingani wakho akufanele ukhulelwe ngenkathi uthola i-temsirolimus futhi izinyanga ezintathu ngemuva kokuphela kokwelashwa nge-temsirolimus. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-temsirolimus, shayela udokotela wakho ngokushesha. I-Temsirolimus ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngenkathi uthola i-temsirolimus.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthola i-temsirolimus.
• kufanele wazi ukuthi ungaba sengozini yokuthola ukutheleleka ngenkathi uthola i-temsirolimus. Qiniseka ukuthi ugeza izandla njalo futhi ugweme ukuxhumana nabantu abagulayo.
• awunayo imigomo (isb. isimungumungwane, umkhuhlane wenkukhu, noma imikhuhlane) ngaphandle kokukhuluma nodokotela wakho.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Uma uphuthelwa i-aphoyintimenti ukuthola umthamo we-temsirolimus, shayela udokotela wakho ngokushesha.

I-Temsirolimus ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ubuthakathaka
• ukuvuvukala kwamehlo, izandla, izinyawo, amaqakala, noma imilenze engezansi
• ikhanda
• (amehlo) alumazayo, anamanzi, noma abomvu
• shintsha ngendlela izinto ezinambitha ngayo
• ukuvuvukala, ububomvu, ubuhlungu, noma izilonda emlonyeni noma emphinjeni
• ukulahlekelwa isifiso sokudla
• ukuncipha komzimba
• isicanucanu
• ukuhlanza
• ukuqunjelwa
• isidingo sokuchama kaningi
• ubuhlungu noma ukushisa ngesikhathi uchama
• igazi emchameni
• ukuhlungu obusemhlane
• ubuhlungu bemisipha noma bamalunga
• impumulo enegazi
• izinguquko kuzinzipho noma ezinzwaneni
• isikhumba esomile
• isikhumba esiphaphathekile
• ukukhathala ngokweqile
• ukushaya kwenhliziyo okusheshayo
• induna
• ubunzima bokulala noma ukulala
• ukudana

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• isifuba
• ukuqubuka
• ukulunywa
• ukuphefumula kanzima noma ukugwinya
• ukuqhuma
• ubuhlungu besifuba
• ukuphelelwa umoya
• ukuphefumula okusheshayo noma ukuhefuzela
• ubuhlungu bomlenze, ukuvuvukala, isisa, ubomvu, noma imfudumalo
• ukoma ngokweqile
• indlala eyeqile
• umkhuhlane, umphimbo obuhlungu, amakhaza, ukukhwehlela, nezinye izimpawu zokutheleleka
• ukuquleka
• ubuhlungu obusha noma obukhulayo besisu
• isifo sohudo
• igazi elibomvu endle
• ukuncipha kwenani lomchamo
• ukungaboni kahle
• inkulumo ehamba kancane noma enzima
• ukudideka
• isiyezi noma ukuquleka
• ubuthakathaka noma ukuba ndikindiki kwengalo noma komlenze

I-Temsirolimus ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Le mithi izogcinwa ehhovisi likadokotela wakho noma emtholampilo.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka:

• ukudlikiza
• ukubona izinto ezingekho (ukubona izinto noma ukuzwa amazwi angekho)
• ubunzima bokucabanga kahle, ukuqonda iqiniso, noma ukusebenzisa ukwahlulela okuhle
• ukukhwehlela
• ukuphelelwa umoya
• imfiva
• ubuhlungu obusha noma obukhulayo besisu
• ukuhefuzela noma ukuphefumula ngokushesha
• igazi elibomvu endle
• isifo sohudo
• ubuhlungu bomlenze, ukuvuvukala, isisa, ubomvu, noma imfudumalo

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-temsirolimus.

Buza udokotela wakho uma unemibuzo mayelana nokwelashwa kwakho nge-temsirolimus.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UTorisel^®