Umjovo weDexrazoxane

-Delile

• Ngaphambi kokuthola umjovo we-dexrazoxane,
• Umjovo weDexrazoxane ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka:

Umjovo we-Dexrazoxane (Totect, Zinecard) usetshenziselwa ukuvimbela noma ukunciphisa ukuqina kwemisipha yenhliziyo ebangelwa i-doxorubicin kwabesifazane abathatha umuthi wokwelapha umdlavuza webele osusabalele kwezinye izingxenye zomzimba. Umjovo weDexrazoxane (Totect, Zinecard) unikezwa kuphela abesifazane asebethole inani elithile le-doxorubicin futhi abazodinga ukwelashwa okuqhubekayo kwe-doxorubicin, ayisetshenziselwa ukuvimbela ukulimala kwenhliziyo kwabesifazane abaqala ukwelashwa nge-doxorubicin. Umjovo we-Dexrazoxane (Totect) usetshenziselwa ukunciphisa ukulimala kwesikhumba nezicubu ezingabangelwa lapho umuthi we-anthracycline chemotherapy onjenge-daunorubicin (Cerubidine), doxorubicin (Adriamycin, Doxil), epirubicin (Ellence) noma idarubicin (Idamycin) ivuza ukuphuma umthambo njengoba ujovwa. Umjovo weDexrazoxane usezigabeni zemithi ebizwa nge-cardioprotectants kanye ne-chemoprotectants. Isebenza ngokumisa imithi ye-chemotherapy ekulimazeni inhliziyo nezicubu.

Umjovo weDexrazoxane uza njengempuphu ezohlanganiswa noketshezi bese ujovwa emthanjeni ngudokotela noma ngumhlengikazi esibhedlela. Lapho umjovo we-dexrazoxane usetshenziselwa ukuvimbela ukulimala kwenhliziyo okubangelwa i-doxorubicin, unikezwa ngaphezu kwemizuzu engu-15 ngaphambi nje komthamo ngamunye we-doxorubicin. Lapho umjovo we-dexrazoxane usetshenziselwa ukuvimbela ukulimala kwezicubu ngemuva kokuthi umuthi we-anthracycline usuphumile emthanjeni, unikezwa ngaphezu kwehora elilodwa kuya kwamabili kanye ngosuku izinsuku ezintathu. Umthamo wokuqala unikezwa ngokushesha okukhulu ngaphakathi kwamahora ayisithupha okuqala ngemuva kokuvela kokuvuza, bese imithamo yesibili neyesithathu inikezwa cishe amahora angama-24 kanye nama-48 ngemuva komthamo wokuqala.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-dexrazoxane,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-dexrazoxane, noma imiphi eminye imithi, noma yiziphi izithako zomjovo we-dexrazoxane. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho imikhiqizo ye-dimethylsulfoxide (DMSO).
• utshele udokotela wakho uma uke waba nesifo senhliziyo, sezinso, noma sesibindi.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uhlele ukuba nobaba wengane. Akufanele ukhulelwe ngenkathi uthola umjovo we-dexrazoxane. Uma uthola umjovo we-dexrazoxane (iZinecard), kufanele usebenzise ukulawulwa kokuzalwa ngesikhathi sokwelashwa kwakho. Uma uthola umjovo we-dexrazoxane (Totect), kufanele usebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa kwakho futhi okungenani izinyanga eziyisithupha ngemuva komthamo wakho wokugcina. Uma ungowesilisa, wena nophathina wakho wesifazane kufanele nisebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa futhi izinyanga ezintathu ngemuva kokuyeka ukuthola umjovo we-dexrazoxane (Totect). Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthola umjovo we-dexrazoxane, shayela udokotela wakho. IDexrazoxane ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngenkathi uthola umjovo we-dexrazoxane (Zinecard). Uma uthola umjovo we-dexrazoxane (Totect), akufanele uncelise ibele ngenkathi uthola ukwelashwa kanye namasonto ama-2 ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala emadodeni. Khuluma nodokotela wakho ngezingozi zokuthola umjovo we-dexrazoxane.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthola umjovo we-dexrazoxane.
• kufanele wazi ukuthi ukwelashwa ngomjovo we-dexrazoxane kuyehla kepha akuqedi ubungozi bokuthi i-doxorubicin izolimaza inhliziyo yakho. Udokotela wakho usazodinga ukukuqapha ngokucophelela ukuze abone ukuthi i-doxorubicin iyithinte kanjani inhliziyo yakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Umjovo weDexrazoxane ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ubuhlungu noma ukuvuvukala endaweni lapho kwajova khona umuthi
• isicanucanu
• ukuhlanza
• isifo sohudo
• ukuqunjelwa
• ubuhlungu besisu
• ukulahlekelwa isifiso sokudla
• isiyezi
• ikhanda
• ukukhathala ngokweqile
• ubunzima bokulala noma ukulala
• ukudana
• ukuvuvukala kwezingalo, izandla, izinyawo, amaqakala, noma imilenze engezansi

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• umphimbo obuhlungu, umkhuhlane, amakhaza, ukukhwehlela, nezinye izimpawu zokutheleleka
• ukulimaza noma ukopha okungavamile
• isikhumba esiphaphathekile
• ubuthakathaka
• ukuphelelwa umoya
• ukuqubuka
• ukulunywa
• isifuba
• ukuphefumula kanzima noma ukugwinya
• ukuvuvukala kwamehlo, ubuso, umlomo, izindebe, ulimi, noma umphimbo
• isiyezi
• ukuquleka

Abanye abantu abathathe umuthi ofana kakhulu nomjovo we-dexrazoxane baba nezindlela ezintsha zomdlavuza. Akukho mininingwane eyanele ongayitshela uma ukuthola umjovo we-dexrazoxane kwandisa ubungozi bokuthi uzoba nohlobo olusha lomdlavuza. Khuluma nodokotela wakho ngezingozi zokuthola lo muthi.

Umjovo weDexrazoxane ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka:

• umphimbo obuhlungu, umkhuhlane, amakhaza nezinye izimpawu zokutheleleka
• ukulimaza noma ukopha okungavamile
• isikhumba esiphaphathekile
• ukuphelelwa umoya
• ukukhathala ngokweqile

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho kumjovo we-dexrazoxane.

Buza udokotela wakho noma usokhemisi noma imiphi imibuzo onayo mayelana nomjovo we-dexrazoxane.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Totect^®
• I-Zinecard^®