Eltrombopag

-Delile

• Ngaphambi kokuthatha i-eltrombopag,
• I-Eltrombopag ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

Uma une-hepatitis C engapheli (ukutheleleka ngegciwane okuqhubekayo okungalimaza isibindi) bese uthatha i-eltrombopag nemithi ye-hepatitis C ebizwa nge-interferon (Peginterferon, Pegintron, abanye) ne-ribavirin (iCopegus, iRebetol, iRibasphere, abanye), kukhona ingozi eyengeziwe yokuthi uzoba nokulimala okukhulu kwesibindi. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukuphuzi kwesikhumba noma kwamehlo, umchamo omnyama, ukukhathala ngokweqile, ubuhlungu engxenyeni engaphezulu yesisu, ukuvuvukala kwesisu, noma ukudideka.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zaselabhorathri ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-eltrombopag.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-eltrombopag futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokuthatha i-eltrombopag.

I-Eltrombopag isetshenziselwa ukwandisa inani lama-platelet (amaseli asiza i-clot yegazi) ukunciphisa ingozi yokopha kubantu abadala kanye nezingane ezineminyaka engu-1 ubudala nangaphezulu abane-immune thrombocytopenia engapheli (i-ITP; isimo esiqhubekayo esingadala ukulimaza okungavamile noma ukopha ngenxa yenani eliphansi ngokungajwayelekile lama-platelet egazini) futhi abangasizwanga noma abangalashwa ngezinye izindlela zokwelashwa, kufaka phakathi imishanguzo noma ukuhlinzwa ukususa ubende. I-Eltrombopag nayo isetshenziselwa ukukhulisa inani lama-platelet kubantu abane-hepatitis C (ukutheleleka ngegciwane okungalimaza isibindi) ukuze baqale futhi baqhubeke nokwelashwa nge-interferon (Peginterferon, Pegintron, abanye) kanye ne-ribavirin (iRebetol). I-Eltrombopag isetshenziswa futhi ngokuhlangana neminye imithi yokwelapha i-aplastic anemia (isimo lapho umzimba ungenzi amaseli egazi amasha ngokwanele) kubantu abadala nasezinganeni ezineminyaka engu-2 nangaphezulu. Ibuye isetshenziselwe ukwelapha i-aplastic anemia kubantu abadala abangazange basizwe ngeminye imithi. I-Eltrombopag isetshenziselwa ukwandisa inani lama-platelet ngokwanele ukunciphisa ubungozi bokuphuma kwegazi kubantu abane-ITP noma i-aplastic anemia, noma ukuvumela ukwelashwa nge-interferon ne-ribavirin kubantu abane-hepatitis C. Kodwa-ke ayisetshenziswanga ukukhulisa inani lama-platelet izinga elijwayelekile. I-Eltrombopag akufanele isetshenziselwe ukwelapha abantu abanezinombolo eziphansi zama-platelet ngenxa yezimo ezingezizo ze-ITP, hepatitis C, noma i-aplastic anemia. U-Eltrombopag usesigabeni semithi ebizwa ngama-thrombopoietin receptor agonists. Isebenza ngokwenza amaseli emnkantsheni wethambo akhiqize ama-platelet amaningi.

I-Eltrombopag iza njengethebhulethi nanjengempuphu yokumiswa ngomlomo (uketshezi) ukuthatha ngomlomo. Imvamisa kuthathwa kanye ngosuku esiswini esingenalutho, okungenani ihora eli-1 ngaphambi noma amahora amabili ngemuva kokudla. Thatha i-eltrombopag ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-eltrombopag njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Thatha i-eltrombopag okungenani amahora amabili ngaphambi noma amahora amane ngemuva kokudla noma ukuphuza ukudla okuqukethe i-calcium eningi, njengemikhiqizo yobisi, amajusi aqiniswe nge-calcium, okusanhlamvu, i-oatmeal, nezinkwa; ithrawuthi; izimbaza; imifino eluhlaza enamaqabunga njengesipinashi nemifino ye-collard; kanye ne-tofu neminye imikhiqizo yesoya. Buza udokotela wakho ukuthi awuqinisekile yini ukuthi ukudla kuqukethe i-calcium eningi. Ungakuthola kuwusizo ukuthatha i-eltrombopag eduze nasekuqaleni noma ekupheleni kosuku lwakho ukuze uzokwazi ukudla lokhu kudla ngesikhathi sakho esiningi sokuvuka.

Gwinya wonke amaphilisi. Ungawahlukanisi, ungawahlafune noma uwagxoze bese uwaxuba abe ngukudla noma uketshezi.

Uma uthatha i-powder yokumiswa ngomlomo, funda ngokucophelela imiyalelo yomkhiqizi yokusetshenziswa eza nomuthi. Le miyalo ichaza ukuthi ungalungiselela kanjani futhi ulinganise umthamo wakho. Hlanganisa impuphu namanzi apholile noma abandayo ngaphambi kokuyisebenzisa. Ungahlanganisi impuphu namanzi ashisayo. Masinyane ngemuva kokulungiselela, gwinya umthamo. Uma ingathathiwe kungakapheli imizuzu engama-30 noma uma kukhona uketshezi olusele, lahla ingxube kudoti (ungayitheli phansi kusinki).

Ungavumeli impuphu ukuthi ithinte isikhumba sakho. Uma uchithela impuphu esikhunjeni sakho, yigeze ngokushesha ngensipho namanzi. Shayela udokotela wakho uma unesikhumba noma uma unemibuzo.

Udokotela wakho kungenzeka akuqale ngomthamo ophansi we-eltrombopag futhi alungise umthamo wakho kuye ngempendulo yakho emithini. Ekuqaleni kokwelashwa kwakho, udokotela wakho uyo-oda ukuhlolwa kwegazi ukubheka izinga leplatelet yakho kanye ngesonto. Udokotela wakho angakhuphula umthamo wakho uma izinga lakho leplatelet liphansi kakhulu. Uma izinga lakho leplatelet liphezulu kakhulu, udokotela wakho anganciphisa umthamo wakho noma angakuniki i-eltrombopag okwesikhashana. Ngemuva kokuthi ukwelashwa kwakho kuqhubeke isikhathi esithile futhi udokotela wakho ethole umthamo we-eltrombopag okusebenzela wena, izinga lakho leplatelet lizohlolwa kaningi. Izinga lakho leplatelet lizophinde lihlolwe masonto onke okungenani amasonto ama-4 ngemuva kokuyeka ukuthatha i-eltrombopag.

Uma une-ITP engapheli, ungathola eminye imithi yokwelapha isimo sakho kanye ne-eltrombopag. Udokotela wakho anganciphisa umthamo wakho wale mithi uma i-eltrombopag isebenza kahle kuwe.

I-Eltrombopag ayisebenzi kuwo wonke umuntu. Uma izinga lakho leplatelet lingakhuli ngokwanele ngemuva kokuthi uthathe i-eltrombopag isikhathi esithile, udokotela wakho angakutshela ukuthi uyeke ukuthatha i-eltrombopag.

I-Eltrombopag ingasiza ukulawula isimo sakho kepha ngeke iselaphe. Qhubeka uthathe i-eltrombopag noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-eltrombopag ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-eltrombopag,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-eltrombopag, noma imiphi eminye imithi, noma iziphi izithako ezibhebheni ze-eltrombopag. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ama-anticoagulants (ama-thinner egazi) njenge-warfarin (i-Coumadin, i-Jantoven); i-bosentan (iTracleer); imithi yokwehlisa i-cholesterol (ama-statins) njenge-atorvastatin (Lipitor, eCaduet), i-fluvastatin (Lescol), i-pitavastatin (i-Livalo, i-Zypitamag), i-pravastatin (i-Pravachol), i-rosuvastatin (i-Crestor), ne-simvastatin (i-Zocor, i-Flolopid, e-Vytorin); ezetimibe (Zetia, eVytorin); i-glyburide (i-Diabeta, i-Glynase); imatinib (Gleevec); i-irinotecan (Camptosar, Onivyde); i-olmesartan (iBenicar, e-Azor, eTribenzor); i-lapatinib (iTykerb); methotrexate (Rasuvo, Trexall, abanye); mitoxantrone; i-repaglinide (Prandin): i-rifampin (i-Rimactane, i-Rifadin, e-Rifamate, i-Rifater); i-sulfasalazine (i-Azulfidine); i-topotecan (i-Hycamtin), ne-valsartan (i-Diovan, e-Byvalson, e-Entresto, e-Exforge). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.Eminye imithi eminingi ingase futhi ihlanganyele ne-eltrombopag, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• uma uthatha ama-antacids aqukethe i-calcium, i-aluminium, noma i-magnesium (i-Maalox, i-Mylanta, i-Tums) noma i-vithamini noma amaminerali anezela aqukethe i-calcium, i-iron, i-zinc noma i-selenium, thatha i-eltrombopag amahora amabili ngaphambi noma amahora amane ngemuva kokuyithatha.
• Tshela udokotela wakho uma ungowokuzalwa eMpumalanga Asia (amaShayina, amaJapane, amaTaiwan, noma amaKorea) futhi uma uke noma uke waba ne-cataract (ukufiphalisa ilensi yeso okungadala izinkinga zombono), amahlule egazi, noma yisiphi isimo lokho kwandisa ubungozi bokuthi uzoba negazi, izinkinga zokopha, i-myelodysplastic syndrome (MDS; isifo segazi esingaholela kumdlavuza), noma isifo sesibindi. Phinda utshele udokotela wakho uma uke wahlinzwa ukuze ususe ubende.
• utshele udokotela wakho uma ukhulelwe, noma uhlele ukukhulelwa. Akufanele ukhulelwe ngesikhathi sokwelashwa kwakho nge-eltrombopag. Sebenzisa ukulawulwa kokubeletha okusebenzayo ngenkathi uthola ukwelashwa nezinsuku eziyi-7 ngemuva komthamo wakho wokugcina. Uma ukhulelwa ngenkathi uthatha i-eltrombopag, shayela udokotela wakho.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngenkathi uthatha i-eltrombopag.
• qhubeka nokugwema imisebenzi engadala ukulimala nokopha ngesikhathi sokwelashwa kwakho nge-eltrombopag. I-Eltrombopag inikezwa ukunciphisa ubungozi bokuthi uzophuma kakhulu, kepha kusesengozini yokuthi ukuphuma kwegazi kungahle kwenzeke.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Yeqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa esivamile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile. Ungathathi umthamo ongaphezu koyedwa we-eltrombopag ngosuku olulodwa.

I-Eltrombopag ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuhlungu obusemhlane
• ubuhlungu bemisipha noma imithambo
• ikhanda
• izimpawu zomkhuhlane ezifana nomkhuhlane, ikhanda elibuhlungu, umphimbo obuhlungu, ukukhwehlela, ukukhathala, ukugodola nobuhlungu bomzimba
• ubuthakathaka
• ukukhathala ngokweqile
• ukuncipha kokudla
• ubuhlungu noma ukuvuvukala emlonyeni noma emphinjeni
• ukulahleka kwezinwele
• ukuqubuka
• izinguquko zombala wesikhumba
• ukukhukhumala isikhumba, ukuluma, noma ukushisa
• ukuvuvukala kwamaqakala, izinyawo, noma imilenze engezansi
• amazinyo (ezinganeni)

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuvuvukala, ubuhlungu, isisa, imfudumalo noma ubomvu emlenzeni owodwa
• ukuphefumula kancane, ukukhwehlela igazi, ukushaya kwenhliziyo okusheshayo, ukuphefumula okusheshayo, ubuhlungu lapho uphefumula ngokujulile
• ubuhlungu esifubeni, ezingalweni, emuva, entanyeni, emhlathini, noma esiswini, kuqhuma umjuluko obandayo, ikhanda elikhanyayo
• ukukhuluma okuhamba kancane noma okunzima, ukuba buthakathaka okungazelelwe noma ukuba ndikindiki kobuso, ingalo noma umlenze, ikhanda elingalindelekile, izinkinga zokubona okungazelelwe, ukuhamba kanzima ngokungazelelwe
• ubuhlungu besisu, isicanucanu, ukuhlanza, isifo sohudo
• kunamafu, ukufiphala kombono, noma olunye ushintsho lombono

I-Eltrombopag ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Uma umuthi wakho ufike nephakethe le-desiccant (iphakethe elincane eliqukethe into edonsa umswakama ukugcina umuthi womile), shiya iphakethe ebhodleleni kodwa uqaphele ukuthi ungaligwinyi.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ukuqubuka
• ukushaya kwenhliziyo okwehlisiwe
• ukukhathala ngokweqile

Udokotela wakho uzoku-oda ukuhlolwa kwamehlo ngaphambi nangesikhathi sokwelashwa kwakho nge-eltrombopag.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Promacta^®