Everolimus

-Delile

• Ngaphambi kokuthatha i-everolimus,
• I-Everolimus ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

Ukuthatha i-everolimus kunganciphisa ikhono lakho lokulwa nokutheleleka kubhaktheriya, amagciwane, nesikhunta futhi kwandise ingozi yokuthi uzothola ukutheleleka okungathi sína noma okusongela ukuphila. Uma uke waba ne-hepatitis B (uhlobo lwesifo sesibindi) esikhathini esedlule, ukutheleleka kwakho kungasebenza futhi ungahle ube nezimpawu ngesikhathi ukwelashwa kwakho ne-everolimus. Tshela udokotela wakho uma ngabe uke waba ne-hepatitis B noma wake waba nayo noma uma unayo noma ucabanga ukuthi ungaba nanoma yiluphi uhlobo lokutheleleka manje. Tshela udokotela wakho kanye nosokhemisi uma uthatha eminye imithi ecindezela amasosha omzimba njenge-azathioprine (Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), dexamethasone (Decadron, Dexpak), methotrexate (Rheumatrex, Trexall), prednisolone (Orapred, Pediapred, Prelone), prednisone (Sterapred), sirolimus (Rapamune), kanye ne-tacrolimus (Prograf). Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukukhathala ngokweqile; ukuphuzi kwesikhumba noma kwamehlo; ukulahlekelwa ukudla; isicanucanu; ubuhlungu obuhlangene; umchamo omnyama; indle ephaphathekile; ubuhlungu engxenyeni engenhla yangakwesokudla yesisu; ukuqubuka; ukuchama okunzima, okubuhlungu, noma okuvamile; ubuhlungu bezindlebe noma amanzi; ubuhlungu besono kanye nengcindezi; noma umphimbo obuhlungu, ukukhwehlela, umkhuhlane, ukubanda, ukungazizwa kahle noma ezinye izimpawu zokutheleleka.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ukuze ahlole impendulo yomzimba wakho ku-everolimus.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha [i-Zortress] noma ipheshana lemininingwane yesiguli [i-Afinitor, i-Afinitor Disperz]) lapho uqala ukwelashwa nge-everolimus futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokuthatha i-everolimus.

Ezigulini ezithatha i-everolimus ukuvimbela ukwenqatshwa kokufakelwa kabusha:

Kumele uthathe i-everolimus ngaphansi kweso likadokotela onolwazi ngokunakekela ukufakelwa kweziguli nokunikeza imishanguzo ecindezela amasosha omzimba.

Ingozi yokuthi uzoba nomdlavuza, ikakhulukazi i-lymphoma (umdlavuza wengxenye yamasosha omzimba) noma umdlavuza wesikhumba uyanda ngesikhathi sokwelashwa kwakho ne-everolimus. Tshela udokotela wakho uma wena noma omunye emndenini wakho unomdlavuza wesikhumba noma uke waba nesikhumba esifanele. Ukuze wehlise amathuba okuba nomdlavuza wesikhumba, hlela ukugwema ukukhanya kwelanga okungadingekile noma isikhathi eside noma ukukhanya kwe-ultraviolet (imibhede yokushuka kanye nezibani zelanga) futhi ugqoke izingubo zokuzivikela, izibuko zelanga, nesikrini selanga ngenkathi welashwa. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: indawo ebomvu, ephakanyisiwe, noma emhlophe esikhunjeni; izilonda ezintsha, izigaxa, noma ukushintsha kombala esikhunjeni; izilonda ezingapholi; izigaxa noma uquqaba noma kuphi emzimbeni wakho; izinguquko zesikhumba; ukujuluka ebusuku; izindlala ezivuvukile entanyeni, emakhwapheni, noma emgodini; ukuphefumula kanzima; ubuhlungu besifuba; noma ubuthakathaka noma ukukhathala okungapheli.

Ukuthatha i-everolimus kungakhuphula ubungozi bokuthi uzoba nokutheleleka okuthile okungajwayelekile futhi okungathi sína, kufaka phakathi ukutheleleka ngegciwane le-BK, igciwane elibucayi elingalimaza izinso futhi libangele izinso elitshalwe kabusha lihluleke), kanye ne-leukoencephalopathy eqhubekayo ye-multifocal (PML; okungajwayelekile ukutheleleka kobuchopho okungenakulashwa, ukuvinjelwa, noma ukwelashwa okuvame ukudala ukufa noma ukukhubazeka okukhulu). Shayela udokotela wakho ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo ze-PML: ubuthakathaka ohlangothini olulodwa lomzimba oluba kubi ngokuhamba kwesikhathi; ubulukhuni bezingalo noma bemilenze; izinguquko ekucabangeni kwakho, ekuhambeni, ekulinganiseni, ekukhulumeni, ekubukeni kwamehlo, noma emandleni okuhlala izinsuku ezimbalwa; ikhanda; ukuquleka; ukudideka; noma izinguquko zobuntu.

I-Everolimus ingadala ukujiya kwegazi emithanjeni yegazi yezinso zakho ezifakiwe. Lokhu kungenzeka kakhulu kwenzeke ezinsukwini zokuqala ezingama-30 ngemuva kokufakelwa kwezinso zakho futhi kungadala ukuthi ukufakelwa kungaphumeleli. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: izinhlungu ekuguleni kwakho, iqolo elingezansi, uhlangothi, noma isisu; ukuncipha kokuchama noma ukungabikho ukuchama; igazi emchameni wakho; umchamo onombala omnyama; imfiva; isicanucanu; noma ukuhlanza.

Ukuthatha i-everolimus ngokuhlangana ne-cyclosporine kungadala ukulimala ezinso zakho. Ukuze unciphise le ngozi, udokotela wakho uzolungisa umthamo we-cyclosporine futhi abheke amazinga emithi nokuthi izinso zakho zisebenza kanjani. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukuncipha kokuchama noma ukuvuvukala kwezingalo, izandla, izinyawo, amaqakala noma imilenze engezansi.

Ezifundweni zokwelashwa, abantu abaningi abathathe i-everolimus bafa ezinyangeni ezimbalwa zokuqala ngemuva kokuthola ukufakelwa inhliziyo kunabantu abangazange bathathe i-everolimus. Uma uthole ukufakelwa kwenhliziyo, khuluma nodokotela wakho ngezingozi zokuthatha i-everolimus.

I-Everolimus (i-Afinitor) isetshenziselwa ukwelapha i-renal cell carcinoma (RCC; umdlavuza oqala ezinso) osevele welashwe ngokungaphumeleli ngeminye imithi. I-Everolimus (i-Afinitor) ibuye isetshenziselwe ukwelapha uhlobo oluthile lomdlavuza webele osezingeni eliphezulu osuvele welashwa okungenani ngomunye umuthi. I-Everolimus (i-Afinitor) ibuye isetshenziselwe ukwelapha uhlobo oluthile lomdlavuza wamanyikwe, isisu, amathumbu, noma amaphaphu asakazekile noma athuthukile futhi angenakulashwa ngokuhlinzwa. I-Everolimus (i-Afinitor) ibuye isetshenziselwe ukwelapha izicubu zezinso kubantu abane-tuberous sclerosis complex (TSC; isimo sofuzo esenza ukuthi izicubu zikhule ezithweni eziningi). I-Everolimus (i-Afinitor ne-Afinitor Disperz) isetshenziselwa ukwelapha i-subependymal giant cell astrocytoma (SEGA; uhlobo lwesimila sobuchopho) kubantu abadala kanye nezingane ezineminyaka engu-1 nangaphezulu abane-TSC. I-Everolimus (i-Afinitor Disperz) iyasetshenziswa kanye neminye imithi yokwelapha izinhlobo ezithile zokubanjwa kwabantu abadala nezingane ezineminyaka emibili nangaphezulu abane-TSC. I-Everolimus (i-Zortress) isetshenziswa neminye imithi ukuvimbela ukwenqatshwa kokufakelwa (ukuhlaselwa kwesitho esithwelwe kabusha amasosha omzimba womuntu othole isitho) kubantu abadala abathile abathole ukufakelwa izinso. U-Everolimus usesigabeni semithi ebizwa nge-kinase inhibitors. U-Everolimus welapha umdlavuza ngokuvimba amangqamuzana omdlavuza ukuthi angakhiqizi futhi anciphise ukunikezwa kwegazi kumaseli omdlavuza. I-Everolimus ivimbela ukwenqatshwa kokufakelwa ngokunciphisa umsebenzi wamasosha omzimba.

I-Everolimus iza njengethebhulethi ezothathwa ngomlomo nanjengethebhulethi ezomiswa emanzini futhi ithathe ngomlomo. Lapho i-everolimus ithathwa ukwelapha izimila zezinso, i-SEGA, noma ukuquleka kubantu abane-TSC; RCC; noma umdlavuza webele, i-pancreatic, isisu, amathumbu, noma umdlavuza wamaphaphu, uvame ukuthathwa kanye ngosuku. Lapho i-everolimus ithathwa ukuvimbela ukwenqatshwa kokufakelwa, kuvame ukuthathwa kabili ngosuku (njalo ngamahora ayi-12) ngasikhathi sinye njenge-cyclosporine. I-Everolimus kufanele ihlale ithathwa ngokudla noma njalo ngaphandle kokudla. Thatha i-everolimus cishe ngesikhathi esifanayo (ama) nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-everolimus njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Amaphilisi e-Everolimus angena ngamaphakethe e-blister ngamanye angavulwa ngesikele. Ungavuli i-blister pack uze ulungele ukugwinya ithebhulethi eliqukethe.

Kufanele uthathe amaphilisi e-everolimus noma amaphilisi e-everolimus ukumiswa ngomlomo. Ungathathi inhlanganisela yomibili yale mikhiqizo.

Gwinya wonke amaphilisi ngengilazi egcwele yamanzi; ungawahlukanisi, ungawahlafune noma uwagxoze. Ungathathi amaphilisi achotshoziwe noma aphukile. Tshela udokotela noma usokhemisi wakho uma ungakwazi ukugwinya amaphilisi aphelele.

Uma uphuza amaphilisi ukumiswa ngomlomo (Afinitor Disperz), kufanele uwaxube namanzi ngaphambi kokuwasebenzisa. Ungawagwinyi wonke la maphilisi, futhi ungawahlanganisi nejusi noma yiluphi uketshezi ngaphandle kwamanzi. Ungayilungisi ingxube ngaphezu kwemizuzu engama-60 ngaphambi kokuhlela ukuyisebenzisa, bese uyilahla leyo ngxube uma ingasetshenziswa ngemuva kwemizuzu engama-60. Musa ukulungiselela umuthi endaweni oyisebenzisela ukulungiselela noma ukudla ukudla. Uma uzolungiselela omunye umuntu umuthi, kufanele ugqoke amagilavu ​​ukuvikela ukuxhumana nomuthi. Uma ukhulelwe noma uhlela ukukhulelwa, kufanele ugweme ukulungiselela umuthi omunye umuntu, ngoba ukuxhumana ne-everolimus kungalimaza ingane yakho engakazalwa.

Ungaxuba amaphilisi wokumiswa ngomlomo kusirinji yomlomo noma engilazini encane. Ukulungisa ingxube esirinji yomlomo, susa i-plunger esirinji yomlomo eyi-10-mL bese ufaka inani elinqunyiwe lamaphilisi emgqonyeni wesirinji ngaphandle kokuphula noma ukuchoboza amaphilisi. Ungalungiselela ukufika ku-10 mg we-everolimus esirinji ngasikhathi sinye, ngakho-ke uma umthamo wakho ungaphezu kuka-10 mg, uzodinga ukuwulungiselela ngesirinji yesibili. Faka esikhundleni se-plunger esirinji bese udweba cishe u-5 mL wamanzi kanye no-4 mL womoya kusirinji bese ufaka isirinji esitsheni bese ukhomba ichopho phezulu. Linda imizuzu emithathu ukuvumela amaphilisi ukuthi angene ekumisweni. bese ucosha isipetu bese usijika ngobumnene usibhekise phezulu bese usihlahlela phansi kahlanu. Faka isirinji emlonyeni wesiguli bese ucindezela i-plunger ukuphatha umuthi. Ngemuva kokuthi isiguli sigwinye umuthi, gcwalisa isirinji efanayo nge-5 mL yamanzi kanye ne-4 mL yomoya bese uzungezisa isirinji ukukhipha noma yiziphi izinhlayiya ezisasesipontshini. Nikeza isiguli le ngxube ukuqinisekisa ukuthi ithola yonke imithi.

Ukulungisa ingxube engilazini, faka inani elibekiwe lamathebulethi engilazini encane yokuphuza engabambi ngaphezu kwama-100 mL (cishe ama-ounces ama-3) ngaphandle kokuchoboza noma ukuphula amaphilisi. Ungalungiselela ukufika ku-10 mg we-everolimus engilazini ngasikhathi sinye, ngakho-ke uma umthamo wakho ungaphezu kuka-10 mg, uzodinga ukuwulungiselela engilazini yesibili. Faka ama-25 mL (cishe i-ounce elilodwa) lamanzi engilazini. Linda imizuzu emi-3 bese uvuselela kahle ingxube ngesipuni. Yenza isiguli siphuze yonke ingxube ngokushesha. Faka amanye ama-25 ml wamanzi engilazini bese ugoqoza ngesipuni esifanayo ukuze uhlanze noma yiziphi izinhlayiya ezisengilazini. Yenza isiguli siphuze le ngxube ukuze siqiniseke ukuthi siyithola yonke imithi.

Udokotela wakho angalungisa umthamo wakho we-everolimus ngesikhathi sokwelashwa kwakho kuya ngemiphumela yokuhlolwa kwegazi lakho, impendulo yakho emithini, imiphumela emibi oyitholayo, kanye nezinguquko kweminye imithi oyithatha nge-everolimus.Uma uthatha i-everolimus ukwelapha i-SEGA noma ukuquleka, udokotela wakho uzolungisa umthamo wakho hhayi kaningi ngaphezu kwesisodwa njalo emavikini ayi-1 kuye kwayi-2, futhi uma uthatha i-everolimus ukuvimbela ukwenqatshwa kokufakelwa, udokotela wakho uzolungisa umthamo wakho hhayi kaningi kunesikhathi esisodwa njalo ezinsukwini ezi-4 kuya kwezi-5. Udokotela wakho angamisa ukwelashwa kwakho isikhashana uma uhlangabezana nemiphumela emibi kakhulu. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngenkathi welashwa nge-everolimus.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-everolimus,

• Tshela udokotela wakho kanye nosokhemisi uma une-allergen ku-everolimus, sirolimus (Rapamune), temsirolimus (Torisel), noma imuphi omunye umuthi, noma iziphi izithako ezibhebheni ze-everolimus. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela noma engabhaliswanga, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi uyayisho imishanguzo ebhalwe esigabeni ESIBALULEKILE SESEXWAYISO nanoma yikuphi okulandelayo: ama-enzyme aguqula i-angiotensin (ACE) anjenge-benazepril (Lotensin), i-captopril (iCapoten), i-enalapril (i-Vasotec), i-fosinopril (i-Monopril), i-lisinopril Prinivil, Zestril), moexipril (Univasc) perindopril (Aceon), quinapril (Accupril), ramipril (Altace), noma i-trandolapril (Mavik); i-amprenavir (i-Agenerase), i-atazanavir (i-Reyataz), i-aprepitant (i-Emend), i-carbamazepine (i-Carbatrol, i-Epitol, i-Tegretol), i-clarithromycin (i-Biaxin, e-Prevpac), i-digoxin (i-Digitek, i-Lanoxicaps, i-Lanoxin), i-diltiazem (i-Cardizem, i-Cardizem, i-Cardizem, i-Cardisem efavirenz (e-Atripla, Sustiva), erythromycin (EES, E-Mycin, Erythrocin), fluconazole (Diflucan), fosamprenavir (Lexiva), indinavir (Crixivan), itraconazole (Sporanox), ketoconazole (Nizviraz), Nizoral) , nevirapine (Viramune), nicardipine (Cardene), phenobarbital (Luminal), phenytoin (Dilantin, Phenytek), rifabutin (Mycobutin), rifampin (Rifadin, eRifamate, eRifater), rifapentine (Priftint), ritonavir ), saquinavir (Invirase), telithromycin (Ketek), verapamil (Calan, Covera, Isoptin, Verelan) kanye ne-voriconazole (Vfend). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-everolimus, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• utshele udokotela wakho uma uke waba nesifo sikashukela noma ushukela ophakeme wegazi; amazinga aphezulu we-cholesterol noma i-triglycerides egazini lakho; isifo sezinso noma sesibindi; noma yisiphi isimo esivimbela ekugayeni ukudla okuqukethe ushukela, isitashi, noma imikhiqizo yobisi ngokujwayelekile.
• Tshela udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa Uma ungowesifazane okwaziyo ukukhulelwa, kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho namasonto ayi-8 ngemuva komthamo wakho wokugcina. Uma ungowesilisa nomlingani wesifazane ongakhulelwa, kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho namasonto ama-4 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-everolimus, shayela udokotela wakho. U-Everolimus angalimaza umbungu. Utshele udokotela wakho uma uncelisa. Ungancelisi ibele ngesikhathi sokwelashwa kwakho namasonto ama-2 ngemuva komthamo wakho wokugcina.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-everolimus.
• ungenayo imigomo ngaphandle kokukhuluma nodokotela wakho. Ngesikhathi sokwelashwa kwakho ne-everolimus, kufanele ugweme ukuxhumana okuseduze nabanye abantu abasanda kugonywa.
• khuluma nodokotela wengane yakho ngemigomo yokugoma ingane yakho engadinga ukuyithola ngaphambi kokuqala ukwelashwa kwayo nge-everolimus.
• kufanele wazi ukuthi ungaba nezilonda noma ukuvuvukala emlonyeni wakho ngenkathi welashwa nge-everolimus, ikakhulukazi phakathi namasonto ayisishiyagalombili okuqala okwelashwa. Uma uqala ukwelashwa nge-everolimus, udokotela wakho angakunikeza ukugeza umlomo ukuze unciphise amathuba okuthi uthole izilonda zomlomo noma izilonda futhi wehlise ukuqina kwazo. Landela imiyalo kadokotela wakho yokuthi ungayisebenzisa kanjani le washi yomlomo. Tshela udokotela wakho uma uba nezilonda noma uzwa ubuhlungu emlonyeni wakho. Akufanele usebenzise noma yikuphi ukuhlanza umlomo ngaphandle kokukhuluma nodokotela wakho noma usokhemisi ngoba izinhlobo ezithile zomlomo oqukethe utshwala, i-peroxide, iodine, noma i-thyme zingazilimaza izilonda nokuvuvukala.
• kufanele wazi ukuthi amanxeba noma ukusikeka, kufaka phakathi ukusika esikhunjeni okwenziwe ngesikhathi sokufakelwa kwezinso kungaphola kancane kunokujwayelekile noma kungapholi kahle ngesikhathi sokwelashwa kwakho ne-everolimus. Shayela udokotela wakho ngokushesha uma ukusika esikhunjeni kusuka ekufakweni kwakho kwezinso noma esinye isilonda kuba okufudumele, okubomvu, okubuhlungu, noma ukuvuvukala; igcwalisa igazi, uketshezi, noma ubomvu; noma iqala ukuvula.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Uma ukhumbula umthamo ongabanjwanga kungakapheli amahora angu-6 wesikhathi obehlelelwe ukuwuthatha, thatha umthamo ophuthelwe khona manjalo. Kodwa-ke, uma kudlule amahora angaphezu kwayi-6 kusukela ngesikhathi esihleliwe, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Everolimus ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• ukuqunjelwa
• shintsha emandleni okunambitha ukudla
• ukuncipha komzimba
• umlomo owomile
• ubuthakathaka
• ikhanda
• ubunzima bokulala noma ukulala
• ekhaleni
• isikhumba esomile
• induna
• izinkinga ngezinzipho
• ukulahleka kwezinwele
• ubuhlungu ezingalweni, emilenzeni, emuva noma emalungeni
• amajaqamba
• izikhathi ezingaphendulwanga noma ezingajwayelekile zokuya esikhathini
• ukuphuma kwegazi okunzima
• ubunzima bokuthola noma ukugcina ukwakhiwa
• ukukhathazeka
• ulaka noma ezinye izinguquko ekuziphatheni

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• isifuba
• ukulunywa
• ukuvuvukala kwezandla, izinyawo, izingalo, imilenze, amehlo, ubuso, umlomo, izindebe, ulimi, noma umphimbo
• ukushaqeka
• ukuphefumula kanzima noma ukugwinya
• isifuba
• ukuqhuma
• ubuhlungu besifuba
• ukoma ngokweqile noma indlala
• ukopha okungajwayelekile noma ukulinyazwa
• isikhumba esiphaphathekile
• ukushaya kwenhliziyo okusheshayo noma okungajwayelekile
• isiyezi
• isithuthwane

I-Everolimus inganciphisa ukuzala kwabesilisa nabesifazane. Khuluma nodokotela wakho ngezingozi zokuthatha i-everolimus.

I-Everolimus ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi ebhokisini le-blister efikile, ivaliwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Yigcine ekamelweni lokushisa kude nokukhanya nokushisa okweqile nomswakama (hhayi endlini yangasese). Gcina amaphakethe wamabhamuza namaphilisi omile.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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• Isibambisi Disperz^®
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