Inaliti ye-Ipilimumab

-Delile

• Ngaphambi kokuthola umjovo we-ipilimumab,
• I-Ipilimumab ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi izimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo.

Kusetshenziswa umjovo we-Ipilimumab:

• ukwelapha i-melanoma (uhlobo lomdlavuza wesikhumba) kubantu abadala nasezinganeni ezineminyaka engu-12 nangaphezulu ezingalashwa ngokuhlinzwa noma ezisabalalele kwezinye izingxenye zomzimba.
• ukusiza ukuvimbela i-melanoma ukuthi ingabuyi emuva kokuhlinzwa ukuyikhipha kanye nanoma yimaphi ama-lymph node athintekile.
• ngokuhlangana ne-nivolumab (Opdivo) ukwelapha i-renal cell carcinoma (RCC; uhlobo lomdlavuza oluqala kumaseli ezinso).
• ngokuhlangana ne-nivolumab ukwelapha izinhlobo ezithile zomdlavuza obala ngokocansi (umdlavuza oqala emathunjini amakhulu) kubantu abadala nezingane ezineminyaka engu-12 ubudala nangaphezulu osusakazekele kwezinye izingxenye zomzimba futhi uye waba muncu ngemuva kokwelashwa neminye imishanguzo ye-chemotherapy.
• ngokuhlangana ne-nivolumab ukwelapha i-hepatocellular carcinoma (HCC; uhlobo lomdlavuza wesibindi) kubantu abake baphathwa nge-sorafenib (Nexafar) phambilini.
• ngokuhlanganiswa ne-nivolumab eya ohlotsheni oluthile lomdlavuza wamaphaphu (non-small cell lung lung cancer; NSCLC) kubantu abadala esesakazekele kwezinye izingxenye zomzimba.
• ngokuhlanganiswa ne-nivolumab ne-platinum chemotherapy yokwelapha uhlobo oluthile lwe-NSCLC kubantu abadala olubuyile noma olusabalale kwezinye izingxenye zomzimba.
• ngokuhlanganiswa ne-nivolumab yokwelapha i-mesothelioma enesifo esibuhlungu (uhlobo lomdlavuza oluthinta ulwelwesi lwangaphakathi lwamaphaphu nesifuba) kubantu abadala abangenakususwa ngokuhlinzwa.

Umjovo we-Ipilimumab usesigabeni semithi ebizwa ngama-antibody monoclonal. Isebenza ngokusiza umzimba ukuthi unciphise noma umise ukukhula kwamangqamuzana omdlavuza.

Umjovo we-Ipilimumab uza njengesisombululo (uketshezi) esizofakwa ngaphakathi (emthanjeni) ngudokotela noma umhlengikazi esibhedlela noma esikhungweni sezokwelapha. Lapho i-ipilimumab inikezwa ukwelapha i-melanoma, imvamisa inikezwa ngaphezu kwemizuzu engama-90 kanye njalo emavikini amathathu uma nje udokotela wakho encoma ukuthi uthole ukwelashwa. Lapho i-ipilimumab inikezwa nge-nivolumab ukwelapha i-renal cell carcinoma, i-hepatocellular carcinoma, noma umdlavuza we-colorectal, imvamisa inikezwa ngaphezu kwemizuzu engama-30 kanye njalo emavikini amathathu kuze kube yimithamo emi-4. Lapho i-ipilimumab inikezwa nge-nivolumab noma nge-nivolumab ne-platinum chemotherapy yokwelapha i-NSCLC, imvamisa inikezwa ngaphezu kwemizuzu engama-30 kanye njalo emavikini ayisithupha uma nje udokotela wakho encoma ukuthi uthole ukwelashwa. Lapho i-ipilimumab inikezwa nge-nivolumab yokwelapha i-mesothelioma ebulalayo, ivame ukunikezwa ngaphezu kwemizuzu engama-30 kanye njalo emavikini ayisithupha uma nje udokotela wakho encoma ukuthi uthole ukwelashwa.

Umjovo we-Ipilimumab ungadala ukusabela okubucayi noma okusongela impilo ngesikhathi sokufakwa. Udokotela noma umhlengikazi uzokubuka eduze ngenkathi uthola ukumnika futhi ngemuva nje kokufakwa ukuze aqiniseke ukuthi awunampendulo emikhulu emithini. Tshela udokotela wakho noma umhlengikazi ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo ezingavela ngesikhathi sokufakwa: ukugodola noma ukuqhaqhazela, ukulunywa, ukuqubuka, ukuqhuma, ukuphefumula kanzima, isiyezi, umkhuhlane noma ukuzwa ukuquleka.

Udokotela wakho angahle anciphise ukumnika, abambezele, noma ayeke ukwelashwa kwakho ngomjovo we-ipilimumab, noma akuphathe ngemithi eyengeziwe kuye ngempendulo yakho emithini kanye nanoma imiphi imiphumela emibi ohlangabezana nayo. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-ipilimumab futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-ipilimumab,

• Tshela udokotela kanye nosokhemisi wakho uma une-aleji kumjovo we-ipilimumab, noma imuphi omunye umuthi, noma iziphi izithako zomjovo we-ipilimumab. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi wake wafakelwa isitho somzimba, isifo sesibindi, noma uma isibindi sakho sonakaliswe umuthi noma ukugula. Futhi, tshela udokotela wakho uma uke waba nesifo sokuzilimaza (isimo lapho amasosha omzimba ahlasela khona ingxenye enempilo yomzimba) njengesifo sikaCrohn (isimo lapho amasosha omzimba ehlasela ulwelwesi lwendlela yokugaya edala ubuhlungu , isifo sohudo, ukwehla kwesisindo, nomkhuhlane), i-ulcerative colitis (isimo esidala ukuvuvukala nezilonda kulwelwesi lwekholoni [amathumbu amakhulu] ne-rectum), i-lupus (isimo lapho amasosha omzimba ahlasela khona izicubu nezitho eziningi kubandakanya isikhumba, amalunga, igazi, nezinso), noma i-sarcoidosis (isimo lapho izingqamuzana zamaseli angajwayelekile zikhula ezingxenyeni ezahlukahlukene zomzimba kubandakanya amaphaphu, isikhumba namehlo).
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uzodinga ukwenza isivivinyo sokukhulelwa ngaphambi kokuthola i-ipilimumab. Kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho ngomjovo we-ipilimumab nezinyanga ezi-3 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ukhulelwa ngenkathi uthola umjovo we-ipilimumab, shayela udokotela wakho ngokushesha. Umjovo we-Ipilimumab ungalimaza umbungu.
• tshela udokotela wakho uma uncelisa noma uhlela ukuncelisa. Akufanele uncelise ibele ngenkathi uthola umjovo we-ipilimumab nezinyanga ezi-3 ngemuva komthamo wakho wokugcina.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

I-Ipilimumab ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ubunzima bokulala noma ukulala
• ubuhlungu obuhlangene

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi izimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo.

• ukuncipha kokuchama, igazi emchameni, ukuvuvukala kwezinyawo, amaqakala, noma imilenze ephansi, noma ukulahlekelwa isifiso sokudla
• uhudo, olunegazi noma olumnyama, okulindile, indle enamathelayo, ubuhlungu besisu obukhulu noma isisa, noma umkhuhlane
• ukukhwehlela, ubuhlungu besifuba, noma ukuphefumula okuncane
• ukukhathala, ukudideka, izinkinga zememori, ukubona izinto ezingekho, ukuqubuka, noma intamo elukhuni
• ukuzwa ukhathele, ukwanda kwesifiso sokudla, ukoma okwandisiwe, ukwanda kokuchama, noma ukunciphisa umzimba
• ukushaya kwenhliziyo okusheshayo, ukuzamazama okungalawuleki kwengxenye yomzimba, ukwanda kwesifiso sokudla, noma ukujuluka
• ukukhathala noma ukuvilapha, ukwanda kokuzwela emakhazeni, ukuqunjelwa, ukuqaqamba kwemisipha nobuthakathaka, ukukhuluphala, ukusinda kunokuya esikhathini okujwayelekile noma okungajwayelekile, ukuncipha kwezinwele, ikhanda elibuhlungu, isiyezi, ukucasuka, ukukhohlwa, ukwehla kokushayela ucansi, noma ukudangala
• ukuphuzi kwesikhumba noma kwamehlo, umchamo omnyama (onombala wetiye), ubuhlungu engxenyeni engaphezulu kwesokudla yesisu, isicanucanu, ukuhlanza, noma ukulimaza okulula noma ukopha
• ubuthakathaka obungavamile bemilenze, izingalo, noma ubuso; noma ukuba ndikindiki noma ukuncinza ezandleni noma ezinyaweni
• ukuqubuka noma ngaphandle kokulunywa, isikhumba noma isikhumba, noma izilonda zomlomo
• ukungaboni kahle, ukubona kabili, ubuhlungu bamehlo noma ubomvu, noma ezinye izinkinga zombono

Umjovo we-Ipilimumab ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Buza usokhemisi wakho noma imiphi imibuzo onayo ngomjovo we-ipilimumab.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ngaphambi nangesikhathi sokwelashwa kwakho ukuze abone ukuthi kuphephile yini ukuthola umjovo we-ipilimumab nokuhlola impendulo yomzimba wakho kumjovo we-ipilimumab.

Kwezinye izimo, udokotela wakho uzo-oda ukuhlolwa kwelebhu ngaphambi kokuba uqale ukwelashwa kwakho ukuze ubone ukuthi umdlavuza wakho ungelashwa nge-ipilimumab.

Buza usokhemisi wakho noma imiphi imibuzo onayo ngomjovo we-ipilimumab.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Yervoy^®