I-Boceprevir

-Delile

• Ngaphambi kokuthatha i-boceprevir,
• I-Boceprevir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Boceprevir isetshenziswa kanye neminye imithi emibili (i-ribavirin [i-Copegus, i-Rebetol] ne-peginterferon alfa [Pegasys]) ukwelapha i-hepatitis C engamahlalakhona (ukutheleleka ngegciwane okuqhubekayo okulimaza isibindi) kubantu abangakalashwa ngalesi simo noma Isimo asizange sibe ngcono ngenkathi belashwa nge-ribavirin ne-peginterferon alfa kuphela. IBoceprevir isekilasini lemithi ebizwa ngama-protease inhibitors. Isebenza ngokunciphisa inani le-virus ye-hepatitis C (HCV) emzimbeni. IBoceprevir kungenzeka ingavimbeli ukusabalala kwesifo sokusha kwesibindi kohlobo C kwabanye abantu.

IBoceprevir iza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa ngokudla noma ngesikhwama esincane kathathu ngosuku (njalo ngamahora ayi-7 kuye kwayi-9). Thatha i-boceprevir ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-boceprevir njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Uzothatha i-peginterferon alfa ne-ribavirin amasonto ama-4 ngaphambi kokuthi uqale ukwelashwa nge-boceprevir. Ngemuva kwalokho uzothatha yonke imishanguzo emithathu amasonto ayi-12 kuye kwangama-44. Ngemuva kwalesi sikhathi, uzoyeka ukuthatha i-boceprevir, kepha ungaqhubeka nokuthatha i-peginterferon alfa ne-ribavirin ngenombolo eyengeziwe yamasonto. Ubude bokwelashwa kwakho buxhomeke esimeni sakho, ukuthi uphendula kahle kanjani emithini, nokuthi ngabe unemiphumela emibi kakhulu yini. Qhubeka nokuthatha i-boceprevir, i-peginterferon alfa, ne-ribavirin inqobo nje uma kunqunywe udokotela wakho. Ungayeki ukuthatha noma iyiphi yale mithi ngaphandle kokukhuluma nodokotela wakho noma ngabe uzizwa uphilile.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-boceprevir futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-boceprevir,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-boceprevir, noma imiphi eminye imithi, noma iziphi izithako ezikuma-capsule we-boceprevir. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• utshele udokotela wakho uma uthatha noma iyiphi yale mithi elandelayo noma imikhiqizo yamakhambi: i-alfuzosin (i-Uroxatral); imithi ye-ergot efana ne-dihydroergotamine (i-DHE 45, i-Migranal), i-ergonovine, i-ergotamine (i-Ergomar, eCafergot, eMigergot) noma i-methylergonovine; i-cisapride (Propulsid) (ayitholakali e-U.S.); i-drospirenone (kwezinye izinto zokuvimbela inzalo zomlomo ezifana neBeyaz, Gianvi, Ocella, Safyral, Yasmin, Yaz, neZarah); i-lovastatin (Altoprev, Mevacor); imithi ethile yokuquleka efana ne-carbamazepine (Carbatrol, Equetro, Tegretol), phenobarbital, noma phenytoin (Dilantin); i-midazolam ethathwe ngomlomo; ipimozide (i-Orap); i-rifampin (i-Rifadin, i-Rimactane, e-IsonaRif, e-Rifamate, e-Rifater); i-sildenafil (uphawu lwe-Revatio kuphela olusetshenziselwa isifo samaphaphu); simvastatin (Simcor, eVytorin); i-tadalafil (kuphela i-Adcirca brand esetshenziselwa isifo samaphaphu); ISt John's wort; noma i-triazolam (Halcion). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-boceprevir uma uthatha eyodwa noma ngaphezulu yale mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-alprazolam (i-Niravam, i-Xanax); ama-anticoagulants (’ama-thinner egazi’) afana ne-warfarin (Coumadin); imishanguzo yokulwa nobungozi efana ne-itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), ne-voriconazole (Vfend); i-atorvastatin (Lipitor, eCaduet); i-bosentan (iTracleer); i-budesonide (iPulmicort, iRhinocort, iSymbicort); i-buprenorphine (i-Buprenex, i-Butrans, i-Subutex, i-Suboxone); ama-calcium channel blocker afana ne-felodipine (Plendil), i-nicardipine (i-Cardene), ne-nifedipine (i-Adalat, i-Afeditab, i-Procardia); i-clarithromycin (i-Biaxin); i-colchicine (Colcrys, ku-Col-Probenecid); i-cyclosporine (Gengraf, Neoral, Sandimmune); i-desipramine (i-Norpramin); i-dexamethasone; imithi ethile yokungasebenzi kahle kwe-erectile njenge-sildenafil (Viagra), i-tadalafil (i-Cialis), ne-vardenafil (i-Levitra, i-Staxyn); imishanguzo ethile ye-HIV efana ne-atazanavir ethathwe nge-ritonavir, i-darunavir ethathwe nge-ritonavir, i-efavirenz (i-Sustiva, e-Atripla), i-lopinavir ethathwe nge-ritonavir, ne-ritonavir (i-Norvir, e-Kaletra); imithi ethile yokushaya kwenhliziyo okungajwayelekile njenge-amiodarone (Cordarone, Pacerone), digoxin (Lanoxin), flecainide (Tambocor), propafenone (Rythmol), ne-quinidine; i-methadone (i-Dolophine, i-Methadose); i-midazolam inikezwe ngemithambo (emthanjeni); i-rifabutin (i-Mycobutin); i-salmeterol (iSerevent, e-Advair); i-sirolimus (i-Rapamune); itacrolimus (Prograf); ne-trazodone. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma ngabe wake wafakelwa isitho somzimba, futhi uma uke waba khona noma wake waba ne-anemia (akwanele ngokwanele amaseli abomvu egazini ukuthwala umoya-mpilo uye kuwo wonke umzimba), igciwane lesandulela-ngculazi (i-HIV), lithole ukungasebenzi komzimba i-syndrome (i-AIDS), noma yisiphi esinye isimo esithinta amasosha akho omzimba, noma i-hepatitis B (ukutheleleka ngegciwane okulimaza isibindi) noma yiluphi uhlobo lwesifo sesibindi ngaphandle kwe-hepatitis C.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-boceprevir.
• Tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma kungenzeka ukhulelwe. Uma ungowesilisa, tshela udokotela wakho uma umlingani wakho ekhulelwe, ehlela ukukhulelwa, noma angakhulelwa. I-Boceprevir kumele ithathwe nge-ribavirin engalimaza umbungu kakhulu. Kufanele usebenzise izindlela ezimbili zokulawula ukubeletha ukuvimbela ukukhulelwa kuwe noma kumlingani wakho ngesikhathi sokwelashwa kwakho nale mithi nangezinyanga eziyisithupha ngemuva kokwelashwa kwakho. Khuluma nodokotela wakho mayelana nokuthi yiziphi izindlela okufanele uzisebenzise; Izindlela zokuvimbela inzalo zamahomoni (amaphilisi okulawula ukubeletha, iziqeshana, izimila, izindandatho, noma imijovo) kungenzeka zingasebenzi kahle kwabesifazane abathatha le mithi. Wena noma umlingani wakho kumele nihlolelwe ukukhulelwa inyanga nenyanga ngesikhathi sokwelashwa kanye nezinyanga eziyisithupha ngemuva kokwelashwa kwakho. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha le mithi, shayela udokotela wakho ngokushesha.
• tshela udokotela wakho uma uncelisa.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ophuthelwe ngokudla ngokushesha nje lapho usakukhumbula. Kodwa-ke, uma kungamahora ama-2 noma ngaphansi ngaphambi kwesikhathi esihleliwe sedosi yakho elandelayo, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Boceprevir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• isifo sohudo
• shintsha emandleni okunambitha
• ukulahlekelwa isifiso sokudla
• ukukhathala ngokweqile
• ubunzima bokulala noma ukulala
• ukucasuka
• ukulahleka kwezinwele
• isikhumba esomile
• ukuqubuka

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuphelelwa umoya
• isiyezi
• ukuquleka
• ubuthakathaka
• umphimbo obuhlungu, umkhuhlane, amakhaza nezinye izimpawu zokutheleleka

I-Boceprevir ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Ungagcina ama-capsule ekamelweni lokushisa futhi ungashisi ngokweqile nomswakama (hhayi endlini yangasese) izinyanga ezintathu. Ungagcina futhi ama-capsule esiqandisini kuze kuphele usuku lokuphelelwa isikhathi oluprintwe kulebula. Lahla noma imuphi umuthi osuphelelwe yisikhathi noma ongasadingeki. Khuluma nosokhemisi wakho ngokulahlwa okufanele kwemithi yakho.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-boceprevir.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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