IBosutinib

-Delile

• Ngaphambi kokuthatha i-bosutinib,
• I-Bosutinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

I-Bosutinib isetshenziselwa ukwelapha uhlobo oluthile lwe-myeloid leukemia engamahlalakhona (i-CML; uhlobo lomdlavuza wamangqamuzana amhlophe egazi), kufaka phakathi ukwelashwa kubantu okusanda kutholakala ukuthi banaso lesi simo nakulabo abangasakwazi ukuzuza kweminye imithi ye-CML noma ngubani ongakwazi ukuthatha le mithi ngenxa yemiphumela emibi. UBosutinib usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo sephrotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunqanda ukusabalala kwamangqamuzana omdlavuza.

IBosutinib iza njengethebhulethi ezothathwa ngomlomo. Kuvame ukuthathwa nokudla kanye ngosuku. Thatha i-bosutinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-bosutinib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze. Uma noma imaphi amaphilisi ephukile noma echotshoziwe, ungawathinti ngezandla zakho.

Udokotela wakho angamisa ukwelashwa kwakho okwesikhashana noma unomphela noma alungise umthamo wakho we-bosutinib ngokuya ngempendulo yakho ekwelashweni nanoma yimiphi imiphumela emibi oyitholayo. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Qhubeka nokuthatha i-bosutinib noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-bosutinib ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-bosutinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-bosutinib noma ezinye izithako ezibhebheni ze-bosutinib. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ama-antifungal athile afana ne-ketoconazole ne-itraconazole (Sporanox); i-aprepitant (Hlela); imishanguzo ethile esetshenziselwa ukwelapha i-human immunodeficiency virus (HIV) efana ne-indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), ne-saquinavir (Invirase); imithi yokwehlisa isisu i-asidi (i-proton-pump inhibitors) njenge-esomeprazole (Nexium), i-lansoprazole (i-Prevacid), i-omeprazole (i-Prilosec), i-pantoprazole (i-Protonix), ne-rabeprazole (i-AcipHex); i-diltiazem (iCardizem, iCartia, iTiazac); i-erythromycin (E.E.S., E-Mycin, Erythrocin); nefazodone; i-rifabutin (i-Mycobutin); ne-rifampin (iRifadin, iRimactane eRifamate, eRifater). Eminye imishanguzo eminingi ingaxhumana ne-bosutinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• uma uthatha ama-antacids, njenge-aluminium hydroxide / magnesium hydroxide (Maalox), i-calcium carbonate (Tums) noma i-calcium carbonate ne-magnesium (i-Rolaids) noma imishanguzo yokwehlisa i-acid esiswini, njenge-cimetidine (Tagamet), i-famotidine (i-Pepcid), noma i-ranitidine (iZantac), thatha amahora amabili ngaphambi noma ngemuva kwamahora amabili uthathe i-bosutinib.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• utshele udokotela wakho uma uke waba nesifo sezinso, isibindi noma senhliziyo.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uzodinga ukuthatha ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa futhi akufanele ukhulelwe ngenkathi uthatha i-bosutinib. Kufanele usebenzise indlela ephumelelayo yokulawula ukubeletha ngenkathi welashwa nge-bosutinib nangamasonto ama-2 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ukhulelwa ngenkathi uthatha i-bosutinib, shayela udokotela wakho. IBosutinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngenkathi uthatha i-bosutinib namasonto ama-2 ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala kwabesilisa nabesifazane. Khuluma nodokotela wakho ngezingozi zokuthatha i-bosutinib.

Ungadli isithelo samagilebhisi, uphuze ijusi lamagilebhisi, noma uthathe noma isiphi isengezo esine-grapefruit ekhishwe ngenkathi uthatha lo muthi.

Thatha umthamo ophuthelwe ngokudla ngokushesha nje lapho usakukhumbula.Kodwa-ke, uma sekudlule amahora angaphezu kwe-12 kusuka kumthamo wakho wokugcina, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Bosutinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• ukulahlekelwa isifiso sokudla
• ukukhathala noma ubuthakathaka

• shintsha emandleni okunambitha ukudla
• kukhala ezindlebeni

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• isicanucanu
• ukuhlanza
• isifo sohudo
• ubuhlungu bendawo yesisu ngokuzumayo
• ukopha noma ukulimaza okungachazeki
• igazi emchameni noma esitulweni
• shintsha kumvamisa wokuchama
• ukwandisa noma ukunciphisa inani lomchamo
• isiyezi
• umkhuhlane, umphimbo obuhlungu, amakhaza, noma ezinye izimpawu zokutheleleka
• ukuphefumula kanye nokukhwehlela
• ubuhlungu besifuba
• ukuvuvukala kobuso, izandla, amaqakala, izinyawo, noma imilenze ephansi
• ukuzuza kwesisindo ngokungazelelwe
• ukuphuzi kwesikhumba namehlo
• umchamo omnyama noma ophuzi wetiye
• isifuba
• ukuqubuka
• ukulunywa
• ukuphefumula kanzima noma ukugwinya

I-Bosutinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-bosutinib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UBosulif^®