I-Bedaquiline

-Delile

• Ngaphambi kokuthatha i-bedaquiline,
• I-Bedaquiline ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Bedaquiline kufanele isetshenziselwe kuphela ukwelapha abantu abanofuba olungazweli emishanguzweni (MDR-TB; ukutheleleka okungathi sína okuthinta amaphaphu nezinye izingxenye zomzimba futhi okungalashwa okungenani ngemithi emibili evame ukusetshenziselwa welapha isimo) lapho ezinye izindlela zokwelapha zingenakusetshenziswa. Esifundweni somtholampilo, kube nokufa okuningi phakathi kwabantu abathathe i-bedaquiline kunabantu abangawuthathi umuthi. Kodwa-ke, i-MDR-TB iyisifo esisongela impilo, ngakho-ke wena nodokotela wakho ninganquma ukuthi kufanele nelashwa nge-bedaquiline uma ezinye izindlela zokwelapha zingenakusetshenziswa.

I-Bedaquiline ingadala ushintsho olubucayi noma olusongela impilo esigqi senhliziyo yakho. Uzodinga ukuba ne-electrocardiogram (ECG; isivivinyo esilinganisa umsebenzi kagesi wenhliziyo) ngaphambi kokwelashwa kwakho nezikhathi eziningana ngesikhathi sokwelashwa kwakho ukubona ukuthi lo muthi usithinta kanjani isigqi senhliziyo yakho. Tshela udokotela wakho uma wena noma omunye emndenini wakho enesikhathi eside i-QT syndrome (inkinga yenhliziyo engajwayelekile engadala ukushaya kwenhliziyo okungajwayelekile, ukuquleka, noma ukufa okungazelelwe) futhi uma uke waba nokushaya kwenhliziyo okuhamba kancane noma okungajwayelekile, indlala yegilo engasebenzi, amazinga aphansi we-calcium, i-magnesium, noma i-potassium egazini lakho, ukwehluleka kwenhliziyo, noma ukuhlaselwa yinhliziyo muva nje. Tshela udokotela kanye nosokhemisi wakho uma usebenzisa noma iyiphi yale mithi elandelayo: azithromycin (Zithromax), ciprofloxacin (Cipro), clarithromycin (Biaxin), clofazimine (Lamprene), erythromycin (EES, E-Mycin, Erythrocin), gemifloxacin (Factive) , levofloxacin (Levaquin), moxifloxacin (Avelox), ne-telithromycin (Ketek). Uma uhlakulela ukushaya kwenhliziyo okusheshayo noma okungajwayelekile noma uma uquleka, shayela udokotela wakho ngokushesha.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-bedaquiline futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokuthatha i-bedaquiline.

I-Bedaquiline isetshenziswa kanye neminye imishanguzo okungenani emithathu yokwelapha isifo sofuba esingazweli emishanguzweni (MDR-TB; ukutheleleka okungathi sína okuthinta amaphaphu nezinye izingxenye zomzimba futhi okungalashwa ngeminye imishanguzo ejwayele ukusetshenziselwa ukwelapha isimo) kubantu abadala nezingane ezineminyaka engu-5 nangaphezulu abanesisindo okungenani esingama-33 lbs (15 kg) athinte amaphaphu. I-Bedaquiline akufanele isetshenziselwe ukwelapha i-TB ethinta kakhulu ezinye izitho zomzimba. I-Bedaquiline isekilasini lemithi ebizwa ngama-anti-mycobacterials. Isebenza ngokubulala amagciwane abanga i-MDR-TB.

IBedaquiline iza njengethebhulethi yokuphuza ngomlomo ngamanzi. Imvamisa kuthathwa ngokudla kanye ngosuku amasonto ama-2 bese kathathu ngesonto amasonto angama-22. Uma uthatha i-bedaquiline kathathu ngesonto, vumela okungenani amahora angama-48 phakathi kwemithamo. Thatha i-bedaquiline ngasikhathi sosuku nangezinsuku ezifanayo zesonto masonto onke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-bedaquiline njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Uma wena noma ingane yakho ningakwazi ukugwinya ithebhulethi engu-20 mg ephelele, ningahle niyihlephule ibe uhhafu kukora wamaphuzu.

Uma wena noma ingane yakho ningakwazi ukuwagwinya amaphilisi angama-20 mg ephelele noma engxenyeni, amaphilisi angachithwa kutipuni elilodwa lamanzi (5 ml) wamanzi enkomishini yokuphuza (awekho ngaphezu kwamathebulethi ayi-5). Ungayiphuza le ngxube ngokushesha noma ukwenza kube lula ukuyifaka, engeza okungenani isipuni esingu-1 (5 ml) samanzi angeziwe, umkhiqizo wobisi, ujusi we-apula, ujusi we-orange, ujusi we-cranberry, noma isiphuzo se-carbonated, noma okunye, ukudla okuthambile engezwe. Bese ugwinya yonke ingxube ngokushesha. Ngemuva kokuthatha umthamo, hlambulula inkomishi ngesamba esincane soketshezi olungeziwe noma ukudla okuthambile bese uyithatha ngokushesha ukuze uqiniseke ukuthi uthola wonke umthamo. Uma udinga amaphilisi angaphezu kwamahlanu angama-20 mg we-bedaquiline, phinda izinyathelo ezingenhla uze ufike kumthamo wakho onqunyiwe.

Ngenye indlela, ukwenza kube lula ukugwinya, ungaphinde uqede amaphilisi angama-20 mg bese ufaka ekudleni okuthambile okufana neyogathi, i-appleauce, ubhanana ocubuziwe, noma i-oatmeal bese ugwinya yonke ingxube ngokushesha. Ngemuva kokuthatha umthamo, engeza inani elincane lokudla okuthambile futhi uthathe ngokushesha ukuze uqiniseke ukuthi uthola wonke umthamo.

Uma uneshubhu le-nasogastric (NG), udokotela wakho noma usokhemisi uzokuchazela ukuthi ungayilungisa kanjani i-bedaquiline ukunikela ngethumbu le-NG.

Qhubeka nokuthatha i-bedaquiline uze uqede imishanguzo kadokotela futhi ungaphuthelwa imithamo, noma ngabe uzizwa ungcono. Uma uyeka ukuthatha i-bedaquiline maduzane noma weqe imithamo, ukutheleleka kwakho kungenzeka kungalashwa ngokuphelele futhi amabhaktheriya angamelana nemithi elwa namagciwane. Lokhu kuzokwenza ukutheleleka kwakho kube nzima ukuselapha ngokuzayo. Ukwenza kube lula kuwe ukuthatha yonke imithi yakho njengokuyalelwa, ungahlanganyela ohlelweni lokwelashwa olubhekwe ngqo. Kulolu hlelo, umsebenzi wezokunakekelwa kwezempilo uzokunikeza umthamo ngamunye wemithi futhi uzokubuka njengoba ugwinya umuthi.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-bedaquiline,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-bedaquiline, noma imuphi omunye umuthi, noma iziphi izithako ezikumaphilisi e-bedaquiline. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela noma engabhaliswanga, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi uyayisho imithi efakwe kuhlu esigabeni ESIBALULEKILE SESEXWAYISO nanoma yikuphi okulandelayo: carbamazepine (Equetro, Tegretol, Teril, others); imishanguzo ethile yokutheleleka ngegciwane lesandulela ngculazi (i-HIV) okubandakanya i-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), lopinavir (eKaletra), nelfinavir (Viracept), ritonavir (Norvir, eKaletra, eViekira Pak); itraconazole (Onmel, Sporanox); ketoconazole (Nizoral); nefazodone; i-phenobarbital; i-phenytoin (iDilantin); i-rifabutin (i-Mycobutin); i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); kanye ne-rifapentine (Priftin). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-bedaquiline, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• utshele udokotela wakho uma ngabe uke waba ne-HIV noma wake waba nayo, noma isifo sesibindi noma sezinso.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-bedaquiline, shayela udokotela wakho. Uma uncelisa, tshela udokotela wakho uma ingane yakho inamehlo aphuzi noma isikhumba noma izinguquko kumbala womchamo noma isitulo sayo.
• gwema ukuphuza iziphuzo ezidakayo ngenkathi uthatha i-bedaquiline. Ukuphuza utshwala kwandisa ingozi yokuthi uzoba nemiphumela emibi kakhulu nge-bedaquiline.

Khuluma nodokotela wakho mayelana nokudla isithelo samagilebhisi nokuphuza ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Uma uphuthelwa umthamo phakathi namasonto amabili okuqala wokwelashwa kwakho, weqa umthamo ongabanjwanga bese uqhubeka nesimiso sakho sokulinganisa okuvamile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

Uma uphuthelwa umthamo kusuka esontweni lesi-3 kuwo wonke amasonto asele okwelashwa kwakho, thatha isilinganiso esilahlekile ngokudla ngokushesha nje lapho usakukhumbula bese uqhubeka nohlelo lwakho lokulinganisa izikhathi ezi-3 ngesonto. Qiniseka ukuthi kukhona okungenani amahora angama-24 phakathi kokuthatha umthamo ongabanjwanga kanye nomthamo ohleliwe olandelayo. Ungathathi umthamo ophindwe kabili ukwenzela okulahlekile noma uthathe okungaphezu komthamo wakho wamasonto onke esikhathini esiyizinsuku ezingu-7.

I-Bedaquiline ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ubuhlungu obuhlangene
• ikhanda
• ukuqubuka

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukukhathala ngokweqile
• ukulahlekelwa isifiso sokudla
• isicanucanu
• ukuphuzi kwesikhumba noma kwamehlo
• umchamo onombala omnyama
• ukunyakaza okukhanyayo okukhanyayo
• ubuhlungu endaweni ephezulu yesisu
• imfiva
• ekhwehlela igazi
• ubuhlungu besifuba

I-Bedaquiline ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Ukugcine ekamelweni lokushisa kude nokukhanya, ukushisa okweqile nomswakama (hhayi endlini yangasese). Gcina iphakethe le-desiccant (omisa i-ejenti) ebhodleleni lemithi ukugcina amaphilisi omile.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-bedaquiline.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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