I-Ado-trastuzumab Emtansine Injection

-Delile

• Ngaphambi kokuthola i-ado-trastuzumab emtansine,
• I-Ado-trastuzumab emtansine ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Ado-trastuzumab emtansine ingadala izinkinga zesibindi ezinzima noma ezisongela impilo. Tshela udokotela wakho uma ngabe uke waba nesifo sesibindi, noma i-hepatitis. Udokotela wakho uzo-oda izivivinyo zaselebhu njalo ngaphambi nangesikhathi sokwelashwa kwakho ukubona ukuthi i-ado-trastuzumab emtansine iyasithinta yini isibindi sakho. Udokotela wakho angakutshela ukuthi akufanele uthole le mithi uma izivivinyo zibonisa ukuthi unenkinga yesibindi. Tshela udokotela wakho kanye nosokhemisi ngayo yonke imithi oyiphuzayo ukuze bakwazi ukubheka ukuthi ngabe ikhona yini imishanguzo yakho engakhuphula ubungozi bokuthi uzoba nokulimala kwesibindi ngesikhathi ukwelashwa kwakho nge-ado-trastuzumab emtansine. Shayela udokotela wakho ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo: isicanucanu, ukuhlanza, ukukhathala ngokweqile, ukungabi namandla, ukulahlekelwa isifiso sokudla, ubuhlungu engxenyeni engakwesokudla esiswini, ukuphuzi kwesikhumba noma kwamehlo, umchamo onombala omnyama, izimpawu ezinjengomkhuhlane, ukudideka, ukozela, noma ukukhuluma okungacaci.

I-Ado-trastuzumab emtansine nayo ingadala izinkinga zenhliziyo ezinkulu noma ezisongela impilo. Tshela udokotela wakho uma uke waba nesifo senhliziyo, isifo senhliziyo, ubuhlungu besifuba, noma ukushaya kwenhliziyo okungajwayelekile. Udokotela wakho uzo-oda ukuhlolwa ngaphambi nangesikhathi sokwelashwa kwakho ukuze abone ukuthi inhliziyo yakho isebenza kahle ngokwanele yini ukuthi uthole ngokuphepha i-ado-trastuzumab emtansine. Udokotela wakho angakutshela ukuthi akufanele uthole le mithi uma izivivinyo zibonisa ukuthi amandla enhliziyo yakho okupompa igazi anciphile. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukukhwehlela; ukuphelelwa umoya; ukuvuvukala kwezingalo, izandla, izinyawo, amaqakala noma imilenze engezansi; ukukhuluphala (ngaphezu kwamakhilogremu ama-5 [cishe ama-2.3 kilograms] ngamahora angama-24); isiyezi; ukulahlekelwa ukwazi; noma ukushaya kwenhliziyo okusheshayo, okungajwayelekile, noma okushaya ngamandla.

Tshela udokotela wakho uma ukhulelwe noma uma wena noma umlingani wakho uhlela ukukhulelwa. I-Ado-trastuzumab emtansine ingalimaza ingane yakho engakazalwa. Uma ungakhulelwa, kuzodingeka ube nokuhlolwa kokukhulelwa okungekuhle ngaphambi kokuqala ukwelashwa nge-ado-trastuzumab emtansine. Kufanele usebenzise ukulawulwa kokubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nezinyanga eziyi-7 ngemuva komthamo wakho wokugcina. Uma ungowesilisa futhi umlingani wakho angakhulelwa, kufanele usebenzise ukulawulwa kokubeletha ngenkathi uthola lo muthi, nezinyanga ezi-4 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma wena noma umlingani wakho ukhulelwa ngesikhathi sokwelashwa kwakho nge-ado-trastuzumab emtansine, shayela udokotela wakho ngokushesha.

Khuluma nodokotela wakho ngezingozi zokuthola umjovo we-ado-trastuzumab emtansine.

Umjovo we-Ado-trastuzumab emtansine usetshenziselwa ukwelapha uhlobo oluthile lomdlavuza webele osusabalele kwezinye izingxenye zomzimba futhi awuzange uthuthuke noma uye waba mubi ngemuva kokwelashwa ngeminye imithi. I-Ado-trastuzumab emtansine nayo iyasetshenziswa ngemuva kokuhlinzwa kohlobo oluthile lomdlavuza webele kwabesifazane abake bathola ukwelashwa ngeminye imithi yokwelapha ngamakhemikhali ngaphambi kokuhlinzwa, kodwa kwakusenomdlavuza osasele ezicutshini ezisuswe ngesikhathi sokuhlinzwa. I-Ado-trastuzumab emtansine isekilasini lemithi ebizwa ngama-anti-drug conjugates. Isebenza ngokubulala amangqamuzana omdlavuza.

Umjovo we-Ado-trastuzumab emtansine uza njengempuphu ezoxutshwa noketshezi bese ufakwa (ujove kancane) emthanjeni kadokotela noma ngumhlengikazi esibhedlela noma esikhungweni sezokwelapha. Kuvamise ukujova kanye njalo emavikini amathathu. Ubude bokwelashwa kwakho buncike ekutheni umzimba wakho uphendula kahle kanjani emithini nasemiphumeleni oyitholayo.

Umjovo we-Ado-trastuzumab emtansine ungadala ukusabela okukhulu okuhlobene nokufakwa, okungahle kwenzeke ngesikhathi noma ngemuva nje kokufakwa komuthi. Kufanele kuthathe imizuzu engama-90 ukuthola umthamo wakho wokuqala we-ado-trastuzumab emtansine. Udokotela noma umhlengikazi uzokubheka eduze ukuze abone ukuthi umzimba wakho uphendula kanjani kulo muthi. Uma ungenazo izinkinga ezinkulu lapho uthola umthamo wakho wokuqala we-ado-trastuzumab emtansine, imvamisa kuzothatha imizuzu engama-30 ukuthi uthole isilinganiso ngasinye semithi yakho esele. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, tshela udokotela wakho ngokushesha: ukuqhuma; imfiva; Ukugodola; isiyezi; ikhanda elikhanyayo; ukuquleka; ukuphelelwa umoya; ukuphefumula kanzima; noma ukushaya kwenhliziyo okusheshayo, okungajwayelekile, noma okushaya ngamandla.

Udokotela wakho angadinga ukubambezela ukwelashwa kwakho, anciphise ukumnika, noma ayeke ukwelashwa kwakho uma uhlangabezana nemiphumela ethile emibi. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho nge-ado-trastuzumab emtansine.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola i-ado-trastuzumab emtansine,

• Tshela udokotela wakho kanye nosokhemisi uma une-aleo-trastuzumab emtansine, i-trastuzumab, noma imuphi omunye umuthi, noma yiziphi izithako zomjovo we-ado-trastuzumab emtansine. Buza udokotela wakho noma usokhemisi uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imishanguzo ebhalwe esigabeni ESIBALULEKILE SEXWAYISO nokunye okulandelayo: apixaban (Eliquis), aspirin (Durlaza, e-Aggrenox, abanye), atazanavir (Reyataz, e-Evotaz), cilostazol (Pletal), clarithromycin (Biaxin, e-Prevpac), clopidogrel (Plavix), dabigatran (Pradaxa), dalteparin (Fragmin), dipyridamole (Persantine, e-Aggrenox), edoxaban (Savaysa), enoxaparin (Lovenox), fondaparinux (Arixtra), heparin, indinaonazole (indina) (Onmel, Sporanox), ketoconazole, nefazodone, nelfinavir (Viracept), prasugrel (Effient), ritonavir (Norvir, eKaletra, Technivie, Viekira Pak), rivaroxaban powder (Xarelto), saquinavir (Invirase), telithromycin (Ketirith, ticelekromagcin). Brilinta), vorapaxar (iZontivity), voriconazole (Vfend), ne-warfarin (Coumadin, Jantoven). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma ungowokuzalwa e-Asia, noma uma uke noma uke waba nanoma yiziphi zezimo ezishiwo esigabeni ESIBALULEKILE SESEXWAYISO, ukuphefumula kanzima, ngisho nalapho uphumule, ukwelashwa ngemisebe, noma esinye isimo sezokwelapha.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngenkathi uthola umjovo we-ado-trastuzumab emtansine nezinyanga eziyi-7 ngemuva komthamo wakho wokugcina.

Khuluma nodokotela wakho ngokudla isithelo samagilebhisi nokuphuza ijusi lamagilebhisi ngenkathi uthola lo muthi.

I-Ado-trastuzumab emtansine ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuqunjelwa
• isifo sohudo
• isisu esibuhlungu
• izilonda emlonyeni nasemphinjeni
• umlomo owomile
• izinguquko kwikhono lokunambitha
• ubuhlungu obuhlangene noma besisipha
• ikhanda
• amehlo omile, abomvu, noma acwebe izinyembezi
• ukufiphala kwamehlo
• unenkinga yokulala noma ukuhlala ulele

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• ubuhlungu, ukulunywa, ububomvu, ukuvuvukala, amabhamuza, noma izilonda eduze kwendawo lapho umjovo wafakwa khona
• umkhuhlane, umphimbo obuhlungu, amakhaza, ubunzima bokuchama, ubuhlungu lapho uchama, nezinye izimpawu zokutheleleka
• ukopha ngamakhala nokunye ukopha noma ukulimaza okungavamile
• ezinegazi noma ezimnyama, izitulo zokulinda
• ukuhlanza igazi noma okokusundu okufana nezindawo zekhofi
• ubuhlungu, ukushisa, noma ukuncinza ezandleni noma ezinyaweni, ubuthakathaka bemisipha, inkathazo yokuhamba
• isifuba
• ukuqubuka
• ukulunywa
• ukuphefumula kanzima noma ukugwinya
• isicanucanu; ukuhlanza; ukulahlekelwa ukudla; ukukhathala; ukushaya kwenhliziyo okusheshayo; umchamo omnyama; ukuncipha kwenani lomchamo; ubuhlungu besisu; ukuquleka; ukusangana; noma amajaqamba kanye nama-spasms
• ukuphefumula, ukukhwehlela, ukukhathala ngokweqile

I-Ado-trastuzumab emtansine ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ukopha ngamakhala nokunye ukopha noma ukulimaza okungavamile
• ezinegazi noma ezimnyama, izitulo zokulinda
• ukuhlanza igazi noma okokusundu okufana nezindawo zekhofi

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzoku-oda ukuhlolwa kwelebhu ngaphambi kokuba uqale ukwelashwa kwakho ukuze ubone ukuthi umdlavuza wakho ungelashwa nge-ado-trastuzumab emtansine.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Kadcyla^®