I-Apixaban

-Delile

• Ngaphambi kokuthatha i-apixaban,
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

Uma une-fibrillation ye-atrial (isimo lapho inhliziyo ishaya ngokungajwayelekile, ikhulisa amathuba okuba namahlule emzimbeni, futhi mhlawumbe kubangele ukushaywa unhlangothi) futhi uthatha i-apixaban ukusiza ukuvimbela imivimbo noma amahlule angathi sína egazini, usengozini enkulu ukushaywa unhlangothi ngemuva kokuyeka ukusebenzisa le mithi. Ungayeki ukuthatha i-apixaban ngaphandle kokukhuluma nodokotela wakho. Qhubeka nokuthatha i-apixaban noma ngabe uzizwa uphilile. Qiniseka ukuthi ugcwalisa kadokotela wakho ngaphambi kokuphelelwa yimithi ukuze ungaphuthelwa yimithamo ye-apixaban. Uma udinga ukuyeka ukuthatha i-apixaban, udokotela wakho angahle anikeze enye i-anticoagulant ('blood thinner') ukusiza ukuvimbela igazi ukuba lingakhi futhi likwenze ube nesifo sohlangothi.

Uma une-epidural noma i-spinal anesthesia noma i-puncture yomgogodla ngenkathi uthatha 'i-blood thinner' efana ne-apixaban, usengozini yokuba nefomu le-clot yegazi emgogodleni noma ezungeze umgogodla wakho ongakwenza ukuthi ukhubazeke. Tshela udokotela wakho uma une-catheter ye-epidural esele emzimbeni wakho noma uke waba nokuphindaphinda ama-epidural noma umgogodla ophindaphindiwe, ukukhubazeka komgogodla noma ukuhlinzwa komgogodla. Tshela udokotela kanye nosokhemisi wakho uma ngabe uthatha noma ikuphi kokulandelayo: i-anagrelide (Agrylin); i-aspirin nezinye izidakamizwa ezingezona ukuvuvukala (ama-NSAID) njenge-ibuprofen (Advil, Motrin, abanye), indomethacin (Indocin, Tivorbex), ketoprofen, ne-naproxen (Aleve, Anaprox, abanye); i-cilostazol (i-Pletal); i-clopidogrel (i-Plavix); i-dipyridamole (i-Persantine); i-eptifibatide (i-Integrilin); i-heparin; i-prasugrel (i-Effient); i-ticagrelor (Brilinta); i-ticlopidine; tirofiban (Aggrastat), kanye ne-warfarin (Coumadin, Jantoven). Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ubuthakathaka bemisipha (ikakhulukazi emilenzeni nasezinyaweni), ukuba ndikindiki noma ukuhayiza (ikakhulukazi emilenzeni yakho), noma ukwehluleka ukulawula amathumbu noma isinye.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-apixaban futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokuthatha i-apixaban.

I-Apixaban isetshenziselwa ukusiza ukuvimbela imivimbo noma amahlule egazini kubantu abane-fibrillation ye-atrial (isimo lapho inhliziyo ishaya ngokungahambi kahle, ikhulisa amathuba okuba namahlule emzimbeni futhi mhlawumbe abangele ukushaywa unhlangothi) okungabangelwa yisifo se-valve senhliziyo. I-Apixaban ibuye isetshenziselwe ukuvimbela i-vein thrombosis ejulile (i-DVT; i-clot yegazi, imvamisa emlenzeni) kanye ne-pulmonary embolism (PE; i-clot yegazi emaphashini) kubantu abathola i-hip esikhundleni noma ukuhlinzwa okuguqula amadolo. I-Apixaban nayo isetshenziselwa ukwelapha i-DVT ne-PE futhi ingaqhutshwa ukuvimbela i-DVT ne-PE ukuthi ingenzeki futhi ngemuva kokuthi ukwelashwa kokuqala kuqediwe. U-Apixaban usesigabeni semithi ebizwa nge-factor Xa inhibitors. Isebenza ngokuvimba isenzo sento ethile yemvelo esiza amahlule egazi ukuthi akhe.

I-Apixaban iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa ngokudla noma ngaphandle kokudla kabili ngosuku. Lapho i-apixaban ithathwa ukuvimbela i-DVT ne-PE ngemuva kokuhlinzwa kwe-hip noma idolo, isilinganiso sokuqala kufanele sithathwe okungenani amahora ayi-12 kuye kwangama-24 ngemuva kokuhlinzwa. I-Apixaban ivame ukuthathwa izinsuku ezingama-35 ngemuva kokuhlinzwa kokufakwa kwe-hip kanye nezinsuku eziyi-12 ngemuva kokuhlinzwa kokufakwa kwedolo. Thatha i-apixaban ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-apixaban njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Uma ungakwazi ukugwinya amaphilisi, ungawachoboza uhlanganise namanzi, ijusi le-apula, noma i-appleauce. Gwinya ingxube ngemuva nje kokuyilungisa. I-Apixaban nayo inganikezwa ezinhlotsheni ezithile zamashubhu wokondla. Buza udokotela wakho ukuthi kufanele yini uphuze le mithi kuthubhu yakho yokondla. Landela izinkomba zikadokotela wakho ngokucophelela.

Qhubeka nokuthatha i-apixaban noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-apixaban ngaphandle kokukhuluma nodokotela wakho. Uma uyeka ukuthatha i-apixaban, ingozi yakho yokuqina kwegazi inganda.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-apixaban,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-apixaban, noma imuphi omunye umuthi, noma yiziphi izithako ezibhebheni ze-apixaban. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); i-clarithromycin (i-Biaxin, ku-Prevpac); itraconazole (Onmel, Sporanox); ketoconazole (Nizoral); i-phenytoin (iDilantin, Phenytek); i-rifampin (Rifadin, Rimactane, eRifadin, eRifater); i-ritonavir (iNorvir, eKaletra); i-serotonin reuptake inhibitors (SSRIs) ekhethiwe njenge-citalopram (Celexa), i-fluoxetine (i-Prozac, i-Sarafem, i-Selfemra, ku-Symbyax), i-fluvoxamine (i-Luvox), i-paroxetine (i-Brisdelle, i-Paxil, i-Pexeva) ne-sertraline (i-Zoloft); kanye ne-serotonin ne-norepinephrine reuptake inhibitors (SNRIs) efana ne-duloxetine (Cymbalta), desvenlafaxine (Khedezla, Pristiq), milnacipran (Fetzima, Savella), ne-venlafaxine (Effexor). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-apixaban, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• kufanele wazi ukuthi i-apixaban ingasebenzisana nemithi ethile engasetshenziswa ukukuphatha uma unestroke noma esinye isimo esiphuthumayo sezokwelapha. Uma kunesimo esiphuthumayo, wena noma ilungu lomndeni kufanele utshele udokotela noma abasebenzi bekamelo labezimo eziphuthumayo abakuphathisayo ukuthi uthatha i-apixaban.
• Tshela udokotela wakho uma une-valve yenhliziyo yokufakelwa noma uma wopha kakhulu noma kuphi emzimbeni okungenakunqandwa. Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-apixaban.
• Tshela udokotela wakho uma uke waba nanoma iyiphi inkinga yenkinga yokopha, i-antiphospholipid syndrome (i-APS; isimo esidala amahlule egazi), noma isifo sezinso noma sesibindi.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-apixaban, shayela udokotela wakho.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-apixaban. Udokotela wakho angakutshela ukuthi uyeke ukuthatha i-apixaban ngaphambi kokuhlinzwa noma inqubo. Uma udinga ukuyeka ukuthatha i-apixaban ngoba uyahlinzwa, udokotela wakho angakunikeza umuthi ohlukile ukuvimbela amahlule egazi ngalesi sikhathi. Udokotela wakho uzokutshela ukuthi kufanele uqale nini ukuthatha i-apixaban futhi ngemuva kokuhlinzwa kwakho. Landela lezi zinkomba ngokucophelela.
• Shayela udokotela wakho ngokushesha uma uwa noma uzilimaza, ikakhulukazi uma ushaya ikhanda. Udokotela wakho angadinga ukukuhlola.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• izinsini ezophayo
• ukuphuma kwamakhala
• ukopha okusindayo kwesitho sangasese sowesifazane
• umchamo obomvu, obomvana noma onsundu
• okubomvu noma okumnyama, izitulo zokulinda
• ukukhwehlela noma ukuphalaza igazi noma into ebukeka njengezizathu zekhofi
• ukuvuvukala noma ubuhlungu bamalunga
• ikhanda
• ukuqubuka
• ubuhlungu besifuba noma ukuqina
• ukuvuvukala kobuso noma kolimi
• ukuphefumula kanzima
• isifuba
• uzizwe unesiyezi noma uqulekile

I-Apixaban ivimbela igazi ekunqandeni ngokujwayelekile, ngakho-ke kungathatha isikhathi eside kunokujwayelekile ukuthi uyeke ukopha uma unqunyiwe noma ulimele. Lo muthi ungakudalela ukulimaza noma ukopha kalula. Shayela udokotela wakho ngokushesha uma ukuphuma kwegazi noma ukulimaza kungavamile, kunzima, noma kungenakulawulwa.

I-Apixaban ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Ukugcine ekamelweni lokushisa kude nokukhanya, ukushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ukopha okungajwayelekile noma ukulinyazwa
• umchamo obomvu, onsundu, noma obomvana
• okubomvu noma okumnyama, izitulo zokulinda
• ukukhwehlela noma ukuphalaza igazi noma into ebukeka njengezizathu zekhofi

Gcina wonke ama-aphoyintimenti nodokotela wakho.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• U-Eliquis^®