Dabrafenib

-Delile

• Ngaphambi kokuthatha i-dabrafenib,
• I-Dabrafenib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu shayela udokotela wakho ngokushesha:

I-Dabrafenib isetshenziswa yodwa noma ihlanganiswe ne-trametinib (i-Mekinist) ukwelapha izinhlobo ezithile ze-melanoma (uhlobo lomdlavuza wesikhumba) ongeke welashwe ngokuhlinzwa noma osabalele kwezinye izingxenye zomzimba. Ibuye isetshenziswe kanye ne-trametinib ukwelapha nokuvimbela ukubuya kohlobo oluthile lwe-melanoma ngemuva kokuhlinzwa ukuyikhipha kanye nanoma yimaphi ama-lymph node athintekile. I-Dabrafenib isetshenziswa futhi ngokuhlangana ne-trametinib ukwelapha uhlobo oluthile lomdlavuza wamaphaphu weseli (non-small) wamaphaphu (NSCLC) osabalalele ezicutshini eziseduze noma kwezinye izingxenye zomzimba. Ibuye isetshenziselwe ukwelapha uhlobo oluthile lomdlavuza wegilo osabalalele ezicutshini eziseduze noma kwezinye izingxenye zomzimba ezingaphendulanga ekwelashweni (ngaphambili) kwangaphambilini. UDabrafenib usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo sephrotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunqanda ukusabalala kwamangqamuzana omdlavuza.

UDabrafenib uza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa kabili ngosuku esiswini esingenalutho, ihora eli-1 ngaphambi noma amahora amabili ngemuva kokudla. Thatha i-dabrafenib cishe ngamahora ayi-12 ngokuhlukana ngezikhathi ezifanayo nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-dabrafenib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho. Ungayeki ukuthatha i-dabrafenib ngaphandle kokukhuluma nodokotela wakho.

Gwinya wonke amaphilisi; ungawavuli, ungawaphuli, noma uwagaye.

Udokotela wakho angalungisa umthamo wakho noma ayeke imishanguzo yakho okwesikhashana noma unomphela kuye ngempendulo yakho ekwelashweni nanoma yimiphi imiphumela emibi oyitholayo. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-dabrafenib futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-dabrafenib,

• Tshela udokotela wakho kanye nosokhemisi uma une-allergies ku-dabrafenib, noma imuphi omunye umuthi, noma iziphi izithako kuma-dabrafenib capsules. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-clarithromycin (i-Biaxin, ku-PrevPac); i-dexamethasone; gemfibrozil (Lopid); ketoconazole; i-midazolam; nefazodone; i-rifampin (iRifadin, eRifamate, eRifater, eRimactane); kanye ne-warfarin (Coumadin, Jantoven). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-dabrafenib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• utshele udokotela wakho uma uke waba nesifo sikashukela noma wake waba naso; ukuntuleka kweglucose-6-phosphate dehydrogenase (G6PD) (isimo sofuzo); izinkinga zokopha; izinkinga zamehlo; ukwehluleka kwenhliziyo noma ezinye izinkinga zenhliziyo; isifo sesibindi noma sezinso; noma esinye isimo sezokwelapha.
• tshela udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa, noma uma uhlela ukuba nobaba wengane. Uma ungowesifazane, kuzodingeka ukuthi uhlolwe ukukhulelwa ngaphambi kokuqala ukwelashwa, futhi kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho namasonto ama-2 ngemuva komthamo wakho wokugcina. Uma ungowesilisa futhi umlingani wakho angakhulelwa, kufanele usebenzise ikhondomu ngenkathi usebenzisa lo muthi, futhi amasonto ama-2 ngemuva kokwelashwa kwakho, noma ngabe uke waba ne-vasectomy (ukuhlinzwa ukuvikela isidoda ekuphumeni emzimbeni wakho futhi kubangele ukukhulelwa) . Kufanele wazi ukuthi lo muthi unganciphisa ukuzala kwabesilisa nabesifazane; noma kunjalo, akufanele ucabange ukuthi awukwazi ukukhulelwa noma ukuthi awukwazi ukukhulelisa omunye umuntu. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-dabrafenib, shayela udokotela wakho. I-Dabrafenib ingalimaza umbungu.
• kufanele wazi ukuthi i-dabrafenib ingahle yehle ukusebenza kwezindlela zokuvimbela inzalo zamahomoni (amaphilisi okulawula ukubeletha, amabala, izindandatho, izimila, nemijovo). Kufanele usebenzise enye indlela yokulawula ukubeletha ukuvimbela ukukhulelwa kuwe noma kumlingani wakho ngesikhathi sokwelashwa kwakho nge-dabrafenib kanye namasonto ama-2 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela.
• tshela udokotela wakho uma uncelisa noma uhlela ukuncelisa. Akufanele uncelise ibele ngenkathi uthatha i-dabrafenib kanye namasonto ama-2 ngemuva komthamo wakho wokugcina.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-dabrafenib.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma kungaphansi kwamahora angu-6 kuze kufike umthamo wakho olandelayo ohleliwe, weqa umthamo ongabanjwanga bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Dabrafenib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• ubuhlungu obuhlangene, besisipha, noma beqolo
• isicanucanu
• isifo sohudo
• ukuqunjelwa
• ukulahlekelwa isifiso sokudla
• ukukhwehlela, ikhala eligobayo, noma umphimbo obuhlungu
• ukulahleka kwezinwele
• ukukhathala

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu shayela udokotela wakho ngokushesha:

• izinguquko esikhunjeni (insumpa entsha, isikhumba esibuhlungu, noma iqhubu elibomvu elopha noma lingapholi)
• shintsha ngosayizi noma umbala wemvukuzane
• ukuqubuka, isikhumba esibomvu, noma izinduna
• imfiva
• ukuquleka
• isiyezi, ikhanda elikhanyayo, noma ubuthakathaka
• Ukugodola
• ukuncipha kokuchama
• ukuvuvukala kwezandla, izinyawo, amaqakala, noma imilenze engezansi
• ukuchama kaningi
• ukoma okwandisiwe
• ubuhlungu beso
• izinkophe ezibomvu noma ezivuvukile
• ukuzwela ekukhanyeni
• ukufiphala kombono noma ukushintsha kombono, kufaka phakathi ukubona ama-halos (uhlaka olufiphele oluzungeze izinto) noma amachashazi anemibala
• ukuvuvukala, ubuhlungu, ubomvu, noma ukuxebuka kwesikhumba ezintendeni zezandla nasematheni ezinyawo
• ubuhlungu obuqhubekayo obuqala endaweni yesisu kepha bungasabalala baye emuva
• ukopha okungajwayelekile noma ukulinyazwa
• ezinegazi noma ezimnyama, izitulo zokulinda
• ukukhwehlela noma ukuphalaza igazi noma into ebukeka njengezizathu zekhofi
• ubuhlungu besifuba
• ukuphelelwa umoya
• ukuvuvukala kwezandla, izinyawo, amaqakala noma imilenze engezansi
• ukushaya kwenhliziyo okusheshayo, okungajwayelekile, noma okushaya ngamandla
• ukuphuzi kwesikhumba namehlo

I-Dabrafenib ingakhuphula ubungozi bokuthi uzoba nomdlavuza omusha wesikhumba noma eminye imidlavuza. Khuluma nodokotela wakho ngezingozi zokuthatha lo muthi.

I-Dabrafenib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzoku-oda ukuhlolwa kwelebhu ngaphambi kokuba uqale ukwelashwa kwakho ukuze ubone ukuthi umdlavuza wakho ungelashwa nge-dabrafenib. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-dabrafenib. Udokotela wakho uzohlola isikhumba sakho nganoma yiziphi izinguquko ngaphambili, njalo ezinyangeni ezimbili ngesikhathi sokwelashwa kwakho, futhi kuze kube izinyanga eziyisithupha emva kokwelashwa.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Tafinlar^®