I-Trametinib

-Delile

• Ngaphambi kokuthatha i-trametinib,
• I-Trametinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukuthatha i-trametinib bese ushayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Trametinib isetshenziswa yodwa noma ihlanganiswe ne-dabrafenib (Tafinlar) ukwelapha izinhlobo ezithile ze-melanoma (uhlobo lomdlavuza wesikhumba) ongeke welashwe ngokuhlinzwa noma osabalele kwezinye izingxenye zomzimba. Isetshenziswa ngokuhlangana ne-dabrafenib ukwelapha nokuvimbela ukubuya kohlobo oluthile lwe-melanoma ngemuva kokuhlinzwa ukuyikhipha kanye nanoma yimaphi ama-lymph node athintekile. I-Trametinib isetshenziswa futhi ngokuhlangana ne-dabrafenib ukwelapha uhlobo oluthile lomdlavuza wamaphaphu ongewona omncane (i-NSCLC) osabalalele ezicutshini eziseduze noma kwezinye izingxenye zomzimba. Isetshenziswa ngokuhlangana ne-dabrafenib ukwelapha uhlobo oluthile lomdlavuza wegilo osabalalele ezicutshini eziseduze noma kwezinye izingxenye zomzimba, ezingenakulashwa ngezinye izindlela zokwelapha. UTrametinib usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo sephrotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunqanda ukusabalala kwamangqamuzana omdlavuza.

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I-Trametinib iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa kanye ngosuku esiswini esingenalutho, okungenani ihora eli-1 ngaphambi noma amahora amabili ngemuva kokudla. Thatha i-trametinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-trametinib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho. Ungayeki ukuthatha i-trametinib ngaphandle kokukhuluma nodokotela wakho.

Udokotela wakho angalungisa umthamo wakho we-trametinib ngokuya ngempendulo yakho ekwelashweni nanoma yimiphi imiphumela emibi ohlangabezana nayo. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-trametinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-trametinib, noma imiphi eminye imithi, noma iziphi izithako ezikumaphilisi e-trametinib. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha.
• utshele udokotela wakho uma ngabe uke waba nesifo samaphaphu noma izinkinga zokuphefumula; isifo sikashukela; izinkinga zokopha noma amahlule egazi; i-colitis (ukuvuvukala kwekholoni); izinkinga zesisu; umfutho wegazi ophakeme; inhliziyo, iso, isibindi noma isifo sezinso; noma yiziphi ezinye izimo zezokwelapha.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Akufanele ukhulelwe ngenkathi uthatha i-trametinib. Kufanele usebenzise ukulawulwa kokuzalwa ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nge-trametinib nezinyanga ezi-4 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ukhulelwa ngenkathi uthatha i-trametinib, shayela udokotela wakho. I-Trametinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa noma uhlela ukuncelisa. Akufanele uncelise ibele ngenkathi uthatha i-trametinib nezinyanga ezi-4 ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala kwabesifazane. Khuluma nodokotela wakho ngezingozi zokuthatha i-trametinib.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma kungaphansi kwamahora angu-12 kuze kufike umthamo wakho olandelayo ohleliwe, weqa umthamo ongabanjwanga bese uqhubeka nesimiso sakho sokulinganisa okujwayelekile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Trametinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isikhumba esomile
• izilonda emlonyeni nasolimini
• umlomo owomile
• ukuhlanza
• ukulahlekelwa isifiso sokudla
• shintsha emandleni okunambitha ukudla
• ukukhathala

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukuthatha i-trametinib bese ushayela udokotela wakho ngokushesha:

• ukopha okungajwayelekile noma ukulinyazwa
• ezinegazi noma ezimnyama, izitulo zokulinda
• ukukhwehlela noma ukuphalaza igazi noma into ebukeka njengezizathu zekhofi
• ekhaleni
• isifo sohudo esibi
• ubuhlungu besisu
• isicanucanu
• imfiva
• Ukugodola
• ukushaya kwenhliziyo okusheshayo, okungajwayelekile, noma okushaya ngamandla
• ukuphefumula kanzima
• ubuhlungu besifuba
• ukuvuvukala kobuso, izingalo, imilenze, amaqakala, noma izinyawo
• isiyezi, ikhanda elikhanyayo, noma ubuthakathaka
• ukuphelelwa umoya
• ubuhlungu bomlenze, ukuvuvukala, isisa, ubomvu, noma imfudumalo
• ikhanda elibi kakhulu
• ukukhwehlela
• ukungaboni kahle
• shintsha embonweni, kufaka phakathi ukubona ama-halos (uhlaka olufiphele oluzungeze izinto) noma amachashazi anemibala
• ukulahleka kombono
• ubuhlungu beso
• amehlo omile, abomvu, noma avuvukile
• ukuqubuka, isikhumba esibomvu, noma izinduna
• insumpa
• isigaxa esibomvu esopha noma esingapholi
• shintsha ngosayizi noma umbala wemvukuzane
• ukulunywa
• amabhamuza, izilonda, noma izilonda esikhunjeni noma ezipikili
• ukuluma, ukushisa, ubomvu, ukuvuvukala, ukuxebuka noma ukuqhuma, amabhamuza, noma izilonda ezintendeni zezandla noma ematheni ezinyawo
• ukuchama kaningi
• ukoma okwandisiwe

I-Trametinib ingakhuphula ubungozi bokuthi uzoba nomdlavuza omusha wesikhumba noma eminye imidlavuza. Khuluma nodokotela wakho ngezingozi zokuthatha lo muthi.

I-Trametinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivaliwe ngokuqinile, kude nomswakama nokukhanya, futhi lapho izingane zingafinyeleli khona. Ungafaki amaphilisi kwezinye iziqukathi, njengamabhokisi amaphilisi ansuku zonke noma amasonto. Yigcine esiqandisini, kodwa ungayifaki iqhwa. Ungayikhiphi i-desiccant (iphakethe elincane elifakwe nemithi yokubamba umswakama) ebhodleleni lakho.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• izinkinga zokubona

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze abone ukuthi kuphephile yini kuwe ukuthola i-trametinib nokuhlola impendulo yomzimba wakho ku-trametinib. Udokotela wakho uzobuye ahlole isikhumba sakho ukuthola noma yiziphi izinguquko ngaphambi kokuqala ukwelashwa, njalo ezinyangeni ezimbili ngesikhathi sokwelashwa kwakho, futhi kuze kube izinyanga eziyisithupha emva kokwelashwa. Udokotela wakho uzophinde ahlole umfutho wegazi lakho ngezikhathi ezithile lapho kudingeka.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Mekinist^®