I-Dolutegravir

-Delile

• Ngaphambi kokuthatha i-dolutegravir,
• IDolutegravir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, yeka ukuthatha i-dolutegravir bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Dolutegravir isetshenziswa neminye imithi yokwelapha ukutheleleka ngegciwane lesandulela ngculazi (i-HIV) kubantu abadala nasezinganeni ezinamasonto amane ubudala nangaphezulu ezinesisindo okungenani esingu-6.6 lbs (3 kg). Isetshenziswa futhi ngokuhlangana ne-rilpivirine (Edurant) ukwelapha i-HIV kubantu abadala abathile ukubuyisela imishanguzo yabo ye-HIV ethathwe okungenani izinyanga eziyisithupha. IDolutegravir isekilasini lemithi ebizwa nge-HIV integrase inhibitors. Isebenza ngokunciphisa inani le-HIV egazini lakho nokwandisa inani lamaseli omzimba asiza ukulwa nezifo emzimbeni wakho. Yize i-dolutegravir ingayelaphi i-HIV, ukuyisebenzisa kanye neminye imishanguzo kunganciphisa amathuba okuba ne-immunodeficiency syndrome (i-AIDS) kanye nezifo ezihlobene ne-HIV ezinjengezifo ezibucayi noma umdlavuza. Ukuthatha le mithi kanye nokwenza ucansi oluphephile nokwenza ezinye izinguquko empilweni kunganciphisa ubungozi bokudlulisela (ukusabalalisa) igciwane le-HIV kwabanye abantu.

IDolutegravir iza njengethebhulethi futhi njengethebhulethi yokumiswa (ithebhulethi ezoncibilika kuketshezi) ukuthatha ngomlomo. Imvamisa kuthathwa kanye noma kabili ngosuku noma ngaphandle kokudla. Thatha i-dolutegravir cishe ngesikhathi esifanayo (ama) nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-dolutegravir njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Musa ukuhlafuna, ukusika, noma ukuchoboza amaphilisi wokumiswa ngomlomo. Ungaligwinya lonke ithebhulethi, eyodwa ngasikhathi, noma uwahlanganise namanzi okuphuza ngaphambi kokuwasebenzisa.

Uma uxuba amaphilisi wokumiswa ngomlomo emanzini okuphuza, engeza inombolo enqunyiwe yamathebulethi enkomishini yokulinganisa. Uma uthatha ithebhulethi (1) noma ama-tablet amathathu wokumiswa ngomlomo, engeza ithisipuni elilodwa (5 ml) lamanzi okuphuza enkomishini. Uma uthatha amaphilisi ama-4, 5, noma ama-6 wokumiswa ngomlomo, engeza amathisipuni ama-2 (10 ml) wamanzi okuphuza enkomishini. Ungasebenzisi noma yiluphi olunye uketshezi ukuncibilikisa ithebhulethi. Swayipha inkomishi imizuzu engu-1 noma emibili noma kuze kube yilapho ingxube ichithwa ngokuphelele; ingxube izovela ifu. Lapho ithebhulethi (ama) yokulengiswa ichithwa ngokuphelele, phuza ingxube ngemuva kokuyixuba. Uma sekuphele imizuzu engaphezu kwengu-30 ngemuva kokuxuba ingxube, yilahle leyo ngxube.

Uma unikeza ingane amaphilisi engxube yokulengiswa, qiniseka ukuthi imile lapho iwathatha. Uma kusele ingxube enkomishini, engeza enye isipuni 1 (5 ml) yamanzi okuphuza enkomishini, ujikeleze, bese unikeza ingane konke ukuze uqiniseke ukuthi ingane ithola umthamo ophelele.

Uma unikeza usana ingxube yamathebulethi, sebenzisa isirinji yomlomo enikezwe ukukala nokunikeza umthamo. Beka ichopho lesiponji enkomishini yokufaka umthamo ngomxube olungiselelwe ukuyidonsela esirinji. Faka ichopho lesipontsho somlomo emlonyeni wengane ngokumelene nengaphakathi lesihlathi. Nciphisa kancane i-plunger ukuze unikeze umthamo kancane. Vumela ingane isikhathi sokugwinya ingxube. Faka enye isipuni esingu-1 (5 ml) samanzi okuphuza enkomishini bese uswayipha.Dweba inhlanganisela esele enjinini bese uyinika lonke usana. Phinda uma kukhona enye ingxube esiseleni ukuze uqiniseke ukuthi usana luthola umthamo ophelele. Ingxube kufanele inikezwe ingane kungakapheli imizuzu engama-30 ixubekile. Ngemuva komthamo, geza izinkomishi nezipetu ngokuhlukile ngamanzi. Vumela izingxenye ukuthi zome ngokuphelele ngaphambi kokuhlanganisa kabusha nokugcina.

Ungashintshi kusuka kumathebulethi uye kumathebulethi wokumiswa ngaphandle kokukhuluma nodokotela wakho kuqala.

Qhubeka uthathe i-dolutegravir noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-dolutegravir ngaphandle kokukhuluma nodokotela wakho. Lapho ukunikezwa kwakho kwe-dolutegravir kwehla, thola okuningi kudokotela wakho noma ekhemisi. Uma uyeka ukuthatha i-dolutegravir noma uphuthelwe imithamo, isimo sakho singase sibe sibi kakhulu futhi kube nzima ukuselapha ngemithi.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-dolutegravir,

• Tshela udokotela kanye nosokhemisi wakho uma unegciwane ku-dolutegravir, noma imuphi omunye umuthi, noma iziphi izithako ezikumaphilisi e-dolutegravir. Buza usokhemisi wakho noma hlola imininingwane yesiguli somkhiqizi ukuthola uhlu lwezithako.
• tshela udokotela wakho uma uthatha i-dofetilide (Tikosyn). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-dolutegravir uma uthatha lo muthi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, nezithako zokudla okunomsoco, okwenzayo noma ohlela ukukuthatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: i-dalfampridine (Ampyra); eminye imishanguzo ye-HIV kubandakanya i-efavirenz (Sustiva, e-Atripla), etravirine (Intelence), fosamprenavir (Lexiva) ethathwe nge-ritonavir (Norvir), nevirapine (Viramune), kanye ne-tipranavir (Aptivus) ethathwe nge-ritonavir (Norvir); imishanguzo ethile yokuquleka okubandakanya i-carbamazepine (Carbatrol, Equetro, Tegretol), oxcarbazepine (Oxtellar XR, Trileptal), phenobarbital, ne-phenytoin (Dilantin, Phenytek); i-metformin (iGlumetza, iGlucophage, iRiomet); kanye ne-rifampin (Rifadin, Rimactane, eRifamate, eRifater). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• uma uthatha ama-antacids, laxatives, noma ama-multivitamin aqukethe i-aluminium, i-magnesium, noma i-calcium; izithako ze-calcium; izithako zensimbi; i-sucralfate (iCarafate); noma imishanguzo ephukile efana ne-aspirin ebhajethiwe, thatha amahora amabili ngemuva noma amahora ayisithupha ngaphambi kokuthatha i-dolutegravir. Kodwa-ke, uma uthatha i-dolutegravir ngokudla, ungathatha lezi zithasiselo ngasikhathi sinye lapho uphuza khona i-dolutegravir.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma uke waba nesifo sezinso noma uthola ukwelashwa nge-dialysis noma isifo sesibindi kubandakanya i-hepatitis B noma i-hepatitis C.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uzodinga ukwenza ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa. Khuluma nodokotela wakho ngezindlela ezisebenzayo zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma ukhulelwa ngenkathi uthatha i-dolutegravir, shayela udokotela wakho ngokushesha. IDolutegravir ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele uma utheleleke nge-HIV noma uma udla i-dolutegravir.
• kufanele wazi ukuthi ngenkathi uthatha imishanguzo yokwelapha ukutheleleka nge-HIV, amasosha omzimba wakho angaqina futhi aqale ukulwa nezinye izifo ezazivele zisemzimbeni wakho. Lokhu kungadala ukuthi ube nezimpawu zalezo zifo. Uma unezimpawu ezintsha noma eziya ziba zimbi ngemuva kokuqala ukwelashwa nge-dolutegravir, qiniseka ukuthi utshela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

IDolutegravir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ubunzima bokulala noma ukulala
• ikhanda
• ubuhlungu besisu
• igesi
• isifo sohudo
• ukuzuza kwesisindo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, yeka ukuthatha i-dolutegravir bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuqubuka
• imfiva
• ngizizwa ngigula
• ukukhathala ngokweqile
• ubuhlungu bemisipha noma bamalunga
• isikhumba esishayayo noma esikhanyayo
• amabhamuza noma izilonda emlonyeni
• amehlo abomvu noma avuvukile
• ukuvuvukala kwamehlo, ubuso, izindebe, umlomo, ulimi, noma umphimbo
• ukuphefumula kanzima noma ukugwinya
• ophuzi wamehlo noma isikhumba
• umchamo omnyama
• ukunyakaza kwamathumbu anombala okhanyayo
• isicanucanu
• ukuhlanza
• ukulahlekelwa isifiso sokudla
• ubuhlungu engxenyeni engenhla kwesokudla yesisu

IDolutegravir ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Ungasusi i-desiccant (iphakethe elincane eliqukethe into edonsa umswakama ukugcina umuthi womile) ebhodleleni.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho angalawula izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-dolutegravir.

Gcina i-dolutegravir isesandleni. Ungalindi uze uphelelwe yimithi yokugcwalisa imishanguzo yakho.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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