Ibrutinib

-Delile

• Ibrutinib isetshenziswa:
• Ngaphambi kokuthatha ibrutinib,
• Ibrutinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Ibrutinib isetshenziswa:

• ukwelapha abantu abane-mantle cell lymphoma (MCL; umdlavuza okhula ngokushesha oqala kumaseli amasosha omzimba) asebevele belashwa okungenani ngomunye umuthi wokwelashwa ngamakhemikhali,
• ukwelapha abantu abane-lymphocytic leukemia (CLL; uhlobo lomdlavuza oluqala kumaseli amhlophe egazi) kanye ne-lymphocytic lymphoma (SLL; uhlobo lomdlavuza oqala kakhulu kuma-lymph node),
• ukwelapha abantu abane-Waldenstrom’s macroglobulinemia (WM; umdlavuza okhula kancane oqala kumaseli athile amhlophe egazi emnkantsheni wakho),
• ukwelapha abantu abane-marginal zone lymphoma (MZL; umdlavuza okhula kancane oqala ngohlobo lwamaseli amhlophe egazi alwa nokutheleleka) asevele elashwe ngohlobo oluthile lwemithi yokwelapha ngamakhemikhali,
• nokwelapha abantu abanesifo esihlala njalo sokuxhunyelelwa (cGVHD; inkinga yokufakelwa kwe-stem-cell hematopoietic [HSCT; inqubo ethatha indawo yomnkantsha onezifo ngomongo wethambo onempilo] engaqala isikhashana ngemuva kokufakelwa bese ihlala isikhathi eside ) ngemuva kokuphathwa ngokungaphumeleli ngomuthi owodwa noma ngaphezulu.

U-Ibrutinib usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba ukusebenza kweprotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunqanda ukusabalala kwamangqamuzana omdlavuza.

U-Ibrutinib uza njenge-capsule kanye nethebulethi ukuthatha ngomlomo. Kuvame ukuthathwa kanye ngosuku. Thatha ibrutinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha ibrutinib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya ifayela le- amaphilisi ephelele ngengilazi yamanzi; ungazivuli, ungaziphuli noma uzihlafune. Gwinya ifayela le- amaphilisi ephelele ngengilazi yamanzi; ungazisiki, uzigaye noma uzihlafune.

Uma uthola umjovo we-obinutuzumab (Gazyva) noma i-rituximab (Rituxan), udokotela wakho angakutshela ukuthi uthathe umthamo wakho we-imbrutinib ngaphambi kokuthola umjovo wakho.

Udokotela wakho anganciphisa umthamo wakho, noma aphazamise noma ayeke isivumelwano sakho. Lokhu kuncike ekutheni umuthi usebenza kanjani kuwe kanye nemiphumela emibi oyitholayo. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Qhubeka uthathe ibrutinib noma ngabe uzizwa uphilile. Ungayeki ukuthatha ibrutinib ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha ibrutinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-ibrutinib, noma imuphi omunye umuthi, noma iziphi izithako kuma-capsules e-ibrutinib noma amaphilisi. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: ama-anticoagulants (’ama-thinner egazi’) njenge-warfarin (i-Coumadin, i-Jantoven); ama-antifungals afana ne-fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), ne-voriconazole (Vfend); imishanguzo yama-antiplatelet efana ne-clopidogrel (Plavix), i-prasugrel (i-Effient), i-ticagrelor (i-Brilinta), ne-ticlopidine; i-aprepitant (Hlela); carbamazepine (Carbatrol, Epitol, Tegretol, Teril); i-clarithromycin (i-Biaxin, i-Prevpac), i-digoxin (i-Lanoxin); i-diltiazem (Cardizem, Cartia, Tiazac, abanye); i-erythromycin (i-EES, i-Erythrocin, eminye), imishanguzo ethile yokwelapha igciwane lengculazi (i-HIV) noma i-immunodeficiency syndrome (i-AIDS) efana ne-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, eKaletra), nase-saquinavir (i-Invirase); i-methotrexate (i-Otrexup, i-Rasuvo, i-Trexall, i-Xatmep); nefazodone; i-phenytoin (iDilantin, Phenytek); i-rifampin (i-Rifadin, i-Rifamate, i-Rimactane, abanye); i-verapamil (Calan, Covera, eTarka, abanye); kanye ne-telithromycin (ayisatholakali e-U.S .; Ketek). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi yimiphi imikhiqizo yamakhambi oyithathayo, ikakhulukazi iSt John's Wort.
• utshele udokotela wakho uma unesifo noma usanda kuhlinzwa. Phinda utshele udokotela wakho uma ubhema noma uke waba nesifo sikashukela, ukushaya kwenhliziyo okungajwayelekile, umfutho wegazi ophakeme (umfutho wegazi ophakeme), i-cholesterol ephezulu, izinkinga zokopha, noma isifo senhliziyo, sezinso noma sesibindi.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, ukuncelisa, noma uma uhlela ukuba nobaba wengane. Akufanele ukhulelwe ngenkathi uthatha ibrutinib. Uma ungowesifazane, kuzodingeka wenze ukuhlolwa kokukhulelwa ngaphambi kokuba uqale ukwelashwa futhi kufanele usebenzise ukuvimbela ukukhulelwa ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nge-ibrutinib kanye nenyanga e-1 ngemuva kokuyeka ukuthatha umuthi. Uma ungowesilisa, wena nomlingani wakho wesifazane kufanele nisebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa nge-ibrutinib futhi niqhubeke inyanga eyodwa ngemuva komthamo wakho wokugcina. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha ibrutinib, shayela udokotela wakho ngokushesha. Ibrutinib ingadala ukulimala kwengane.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha ibrutinib. Udokotela wakho angakutshela ukuthi uyeke ukuthatha ibrutinib izinsuku ezintathu kuya kwezi-7 ngaphambi kokuhlinzwa noma inqubo.

Ungadli i-grapefruit noma amawolintshi aseSeville (kwesinye isikhathi asetshenziswe kuma-marmalade), noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Qinisekisa ukuthi uphuza amanzi amaningi noma olunye uketshezi nsuku zonke ngenkathi uthatha ibrutinib.

Thatha umthamo ophuthelwe ngokushesha uma uwukhumbula ngalolo suku. Kodwa-ke, uma ungakhumbuli kuze kube usuku olulandelayo, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa okujwayelekile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

Ibrutinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• isicanucanu
• ukuqunjelwa
• ukuhlanza
• ubuhlungu besisu
• isilungulela noma isisu
• ukuncipha kokudla
• ukukhathala ngokweqile noma ubuthakathaka
• imisipha, ithambo, nobuhlungu bamalunga
• ukuphazamiseka kwemisipha
• ukuvuvukala kwezandla, izinyawo, amaqakala, noma imilenze engezansi
• ukuqubuka
• ukulunywa
• izilonda emlonyeni nasemphinjeni
• ukukhathazeka
• ubunzima bokulala noma ukulala
• ukukhwehlela, ukuvuza noma ikhala eligxishiwe
• ukungaboni kahle
• amehlo owomile noma amanzi
• iso elibomvana

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuvuvukala kobuso, umphimbo, ulimi, izindebe namehlo
• ubunzima bokugwinya noma ukuphefumula
• isifuba
• ukulimaza noma ukopha okungavamile
• umchamo obomvana, obomvu, noma onsundu
• ezinegazi noma ezimnyama, izitulo zokulinda
• ukuphuma kwamakhala
• ukuhlanza kwegazi; noma ukugabha igazi noma okokusundu okufana nezindawo zekhofi
• isithuthwane
• ukushaya kwenhliziyo okusheshayo noma okungajwayelekile
• ukuphelelwa umoya
• Ukungaphatheki kahle kwesifuba
• isiyezi, ikhanda elincanyana noma ukuzwa ukuquleka
• umbono uyashintsha
• ikhanda (elihlala isikhathi eside)
• umkhuhlane, ukubanda, ukukhwehlela, isikhumba esibomvu, esifudumele, noma ezinye izimpawu zokutheleleka
• ukudideka
• izinguquko enkulumweni yakho
• ukuncipha kokuchama
• ukuchama okubuhlungu, okuvamile, noma okuphuthumayo

Ibrutinib ingakhuphula ubungozi bokuthuthukisa izinhlobo ezithile zomdlavuza kubandakanya umdlavuza wesikhumba noma ezinye izitho. Khuluma nodokotela wakho ngezingozi zokuthatha ibrutinib.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Yigcine ekamelweni lokushisa kude nokukhanya, ukushisa okweqile nomswakama hhayi endlini yangasese.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho angalawula izivivinyo ezithile zebhu futhi aqaphe umfutho wegazi lakho ukuhlola impendulo yomzimba wakho ku-ibrutinib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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