Inaliti ye-Mitoxantrone

-Delile

• Ngaphambi kokusebenzisa umjovo we-mitoxantrone,
• Umjovo weMitoxantrone ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

IMitoxantrone kufanele inikezwe kuphela ngaphansi kokuqondisa kukadokotela onolwazi ekusetshenzisweni kwemithi yokwelapha ngamakhemikhali.

IMitoxantrone ingadala ukwehla kwenani lamaseli amhlophe egazi. Udokotela wakho uzo-oda ukuhlolwa kwe-laboratory njalo ngaphambi nangesikhathi sokwelashwa kwakho ukubheka ukuthi inani lamaseli amhlophe egazi emzimbeni wakho lehlile. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: umkhuhlane, amakhaza, umphimbo obuhlungu, ukukhwehlela, ukuchama kaningi noma okubuhlungu, noma ezinye izimpawu zokutheleleka.

Umjovo weMitoxantrone ungadala ukulimala enhliziyweni yakho noma kunini ngesikhathi sokwelashwa kwakho noma izinyanga kuya eminyakeni ngemuva kokuphela kokwelashwa kwakho. Lokhu kulimala kwenhliziyo kungaba kubi futhi kungadala ukufa futhi kungenzeka nakubantu abangenazo izingozi zesifo senhliziyo. Udokotela wakho uzokuhlola futhi enze izivivinyo ezithile ukubheka ukuthi inhliziyo yakho isebenza kahle kangakanani ngaphambi kokuqala ukwelashwa nge-mitoxantrone nokuthi ukhombisa noma yiziphi izimpawu zezinkinga zenhliziyo. Uma usebenzisa umjovo we-mitoxantrone we-multiple sclerosis (MS; isimo lapho izinzwa zingasebenzi kahle, kubangele izimpawu ezinjengobuthakathaka; ukuba ndikindiki; ukulahleka kokuhlangana kwemisipha; nezinkinga ngombono, ukukhuluma, nokulawula isinye), udokotela wakho izophinde yenze izivivinyo ezithile ngaphambi komthamo ngamunye womjovo we-mitoxantrone futhi minyaka yonke ngemuva kokuphothula ukwelashwa kwakho. Lezi zivivinyo zingafaka i-electrocardiogram (ECG; ukuhlolwa okurekhoda umsebenzi kagesi wenhliziyo) kanye ne-echocardiogram (ukuhlolwa okusebenzisa amaza omsindo ukukala amandla enhliziyo yakho okumpompa igazi). Udokotela wakho angakutshela ukuthi akufanele uthole le mithi uma izivivinyo zibonisa ukuthi amandla enhliziyo yakho okupompa igazi anciphile. Tshela udokotela wakho uma ngabe uke waba nanoma yiluphi uhlobo lwesifo senhliziyo noma ukwelashwa ngemisebe (x-ray) endaweni yesifuba. Tshela udokotela kanye nosokhemisi wakho uma uthatha noma wake wathola imithi ethile yokwelashwa ngamakhemikhali efana ne-daunorubicin (Cerubidine), doxorubicin (Doxil), epirubicin (Ellence), noma idarubicin (Idamycin), noma uma uke welashwa nge-mitoxantrone in okwedlule. Ingozi yokulimala kwenhliziyo ingaxhomeka enanini eliphelele le-mitoxantrone elinikezwe umuntu isikhathi esingaphezu kwempilo yonke, ngakho-ke udokotela wakho uzokhawulela inani eliphelele lamanani owatholayo uma usebenzisa le mithi ye-MS. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukuphefumula kanzima, ubuhlungu besifuba, ukuvuvukala kwemilenze noma amaqakala, noma ukushaya kwenhliziyo okungajwayelekile noma okusheshayo.

I-Mitoxantrone ingakhuphula ubungozi bokuthola i-leukemia (umdlavuza wamaseli amhlophe egazi), ikakhulukazi uma inikezwa ngemithamo ephezulu noma kanye neminye imithi ethile yamakhemikhali.

Khuluma nodokotela wakho ngezingozi zokusebenzisa umjovo we-mitoxantrone.

Umjovo we-Mitoxantrone usetshenziselwa abantu abadala abanezinhlobo ezahlukahlukene ze-multiple sclerosis (MS; isifo lapho izinzwa zingasebenzi kahle futhi abantu bangathola ubuthakathaka, ukuba ndikindiki, ukulahleka kokuhlangana kwemisipha, nezinkinga ngombono, ukukhuluma, nokulawula isinye) kufaka phakathi Okulandelayo:

• amafomu wokubuyisela emuva (inkambo yesifo lapho izimpawu zivela khona ngezikhathi ezithile), noma
• ukubuyela emuva okuqhubekayo (inkambo yesifo ngokubuyela emuva ngezikhathi ezithile), noma
• amafomu wesibili aqhubekayo (inkambo yesifo lapho ukubuyela emuva kwenzeka kaningi).

Umjovo weMitoxantrone nawo uyasetshenziswa kanye nemithi ye-steroid ukudambisa izinhlungu kubantu abanomdlavuza we-Prostate ongaphendulanga kweminye imithi. Umjovo weMitoxantrone uyasetshenziswa neminye imithi yokwelapha izinhlobo ezithile ze-leukemia. Umjovo weMitoxantrone usesigabeni semithi ebizwa ngama-anthracenediones. IMitoxantrone iphatha i-MS ngokumisa amaseli athile amasosha omzimba ukuthi afinyelele ebuchosheni nakumgogodla futhi enze umonakalo. IMitoxantrone ilapha umdlavuza ngokumisa ukukhula nokusabalala kwamangqamuzana omdlavuza.

Umjovo weMitoxantrone uza njengoketshezi oluzonikezwa ngemithambo (emthanjeni) ngudokotela noma umhlengikazi esibhedlela noma emtholampilo. Lapho umjovo we-mitoxantrone usetshenziselwa ukwelapha i-MS, uvame ukunikezwa kanye ezinyangeni ezi-3 cishe iminyaka emibili kuya kwemi-3 (isiyonke semithamo eyi-8 kuye kwayi-12). Lapho umjovo we-mitoxantrone usetshenziselwa ukwelapha umdlavuza we-Prostate, uvame ukunikezwa kanye ezinsukwini ezingama-21. Lapho umjovo we-mitoxantrone usetshenziselwa ukwelapha i-leukemia, uzoqhubeka nokuthola lo muthi ngokuya ngesimo sakho nokuthi uphendula kanjani ekwelashweni.

Uma usebenzisa umjovo we-mitoxantrone ye-MS, kufanele wazi ukuthi ilawula i-MS kepha ayiyelaphi. Qhubeka nokuthola ukwelashwa noma ngabe uzizwa uphilile. Khuluma nodokotela wakho uma ungasafuni ukuthola ukwelashwa ngomjovo we-mitoxantrone.

Uma usebenzisa umjovo we-mitoxantrone ye-MS, cela usokhemisi noma udokotela wakho ukuthola ikhophi lemininingwane yomkhiqizi yesiguli.

Umjovo weMitoxantrone kwesinye isikhathi uyasetshenziswa ukwelapha i-non-Hodgkin's lymphoma (NHL; umdlavuza oqala ohlotsheni lwengqamuzana legazi elimhlophe ngokuvamile elilwa nokutheleleka). Khuluma nodokotela wakho ngezingozi zokusebenzisa lo muthi ngesimo sakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokusebenzisa umjovo we-mitoxantrone,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane emzimbeni we-mitoxantrone injection, noma imiphi eminye imithi, ama-sulfite, noma ezinye izithako zomjovo we-mitoxantrone. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imithi efakwe kuhlu esigabeni ESIBALULEKILE SESEXWAYISO. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma ngabe uke waba nezinkinga zokuvala igazi, i-anemia (ukuncipha kwenani lamaseli abomvu egazini), noma isifo sesibindi.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Akufanele ukhulelwe ngenkathi usebenzisa umjovo we-mitoxantrone. Khuluma nodokotela wakho ngezindlela ezisebenzayo zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma ukhulelwa ngenkathi usebenzisa umjovo we-mitoxantrone, shayela udokotela wakho ngokushesha. Umjovo weMitoxantrone ungalimaza umbungu. Uma usebenzisa umjovo we-mitoxantrone ukwelapha i-MS, noma ngabe usebenzisa ukulawulwa kokuzalwa, udokotela wakho kufanele akunikeze isivivinyo sokukhulelwa ngaphambi kokwelapha ngakunye. Kufanele ube nokuhlolwa kokukhulelwa okungekuhle ngaphambi kokuqala kokwelashwa ngakunye.
• tshela udokotela wakho uma uncelisa. Ungancelisi ibele ngenkathi usebenzisa umjovo we-mitoxantrone.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi usebenzisa umjovo we-mitoxantrone.
• kufanele wazi ukuthi umjovo we-mitoxantrone uluhlaza okwesibhakabhaka ngombala futhi kungadala ukuthi izingxenye ezimhlophe zamehlo akho zibe nombala oluhlaza okwesibhakabhaka izinsuku ezimbalwa ngemuva kokuthola umthamo ngamunye. Kungashintsha futhi umbala womchamo wakho ube umbala oluhlaza okwesibhakabhaka cishe amahora angama-24 ngemuva kokuthola umthamo.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Shayela udokotela wakho ngokushesha uma ungakwazi ukugcina i-aphoyintimenti yokuthola umthamo womjovo we-mitoxantrone.

Umjovo weMitoxantrone ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• isifo sohudo
• ukuqunjelwa
• isilungulela
• ukulahlekelwa isifiso sokudla
• izilonda emlonyeni nasolimini
• ikhala eligijimayo noma eligxishiwe
• ukuncipha noma ukulahleka kwezinwele
• izinguquko endaweni ezungeze noma ngaphansi kwezinzipho nezinzwane
• izikhathi ezingaphendulwanga noma ezingajwayelekile zokuya esikhathini
• ukukhathala ngokweqile
• ubuthakathaka
• ikhanda
• ukuhlungu obusemhlane

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• ukopha okungajwayelekile noma ukulinyazwa
• amachashazi amancane abomvu noma ansomi esikhunjeni
• isifuba
• ukulunywa
• ukuqubuka
• ubunzima bokugwinya
• ukuphelelwa umoya
• ukuquleka
• isiyezi
• isikhumba esiphaphathekile
• ukuphuzi kwesikhumba noma kwamehlo
• isithuthwane
• ububomvu, ubuhlungu, ukuvuvukala, ukushisa, noma ukushintsha kombala okuluhlaza okwesibhakabhaka lapho kunikezwe khona umjovo

Umjovo weMitoxantrone ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho kumjovo we-mitoxantrone.

Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nomjovo we-mitoxantrone.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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• I-DHAD

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