Dapagliflozin

-Delile

• Ngaphambi kokuthatha i-dapagliflozin,
• Lo muthi ungadala ushintsho kushukela wakho wegazi. Kufanele wazi izimpawu zikashukela wegazi ophansi futhi ophakeme nokuthi yini okufanele uyenze uma unalezi zimpawu.
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:
• Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, yeka ukuthatha i-dapagliflozin bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo ze-ketoacidosis, yeka ukuthatha i-dapagliflozin bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo. Uma kunokwenzeka, hlola ama-ketone emchameni wakho uma unalezi zimpawu, noma ngabe ushukela wegazi lakho ungaphansi kuka-250 mg / dL:

I-Dapagliflozin isetshenziswa kanye nokudla nokuzivocavoca umzimba, futhi kwesinye isikhathi neminye imishanguzo, ukwehlisa amazinga kashukela kubantu abadala abanesifo sikashukela sohlobo lwesibili (isimo lapho ushukela wegazi uphakeme kakhulu ngoba umzimba awukhiqizi noma usebenzise i-insulin ngokwejwayelekile). I-Dapagliflozin iphinde isetshenziselwe ukunciphisa ubungozi bokudinga ukulaliswa esibhedlela ngenxa yokwehluleka kwenhliziyo kubantu abadala abanesifo sikashukela sohlobo lwesibili kanye nesifo senhliziyo nesifo segazi noma abanezici eziningi eziyingozi zokuthuthukisa isifo senhliziyo nesogazi. I-Dapagliflozin isetshenziswa futhi kubantu abadala abanokwehluleka kwenhliziyo ukunciphisa ubungozi bokudinga ukulaliswa esibhedlela nokufa ngenxa yesifo senhliziyo nesomthambo wegazi. UDapagliflozin usekilasini lemithi ebizwa nge-sodium-glucose co-transporter 2 (SGLT2) inhibitors. Yehlisa ushukela egazini ngokwenza izinso zisuse i-glucose eningi emchameni. I-Dapagliflozin ayisetshenziselwa ukwelapha uhlobo lwesifo sikashukela sohlobo 1 (isimo lapho umzimba ungakhiqizi khona i-insulin, ngakho-ke, awukwazi ukulawula inani likashukela egazini) noma i-ketoacidosis yesifo sikashukela (isimo esibi esingavela uma ushukela ophakeme wegazi ungelashwa ).

Ngokuhamba kwesikhathi, abantu abanesifo sikashukela kanye noshukela ophakeme wegazi bangakhula babe nezinkinga ezinkulu noma ezisongela impilo, kufaka phakathi isifo senhliziyo, isifo sohlangothi, izinkinga zezinso, ukulimala kwemizwa nezinkinga zamehlo. Ukuthatha i-dapagliflozin, ukwenza izinguquko endleleni ophila ngayo (isb., Ukudla, ukuzivocavoca, ukuyeka ukubhema), nokuhlola njalo ushukela wegazi lakho kungasiza ukuphatha isifo sikashukela futhi kuthuthukise impilo yakho. Lokhu kwelashwa kunganciphisa namathuba akho okuhlaselwa yisifo senhliziyo, isifo sohlangothi, noma ezinye izinkinga ezihlobene nesifo sikashukela njengokuhluleka kwezinso, ukulimala kwemizwa (okundikindiki, imilenze ebandayo noma izinyawo; ukwehla kwekhono lezocansi kwabesilisa nabesifazane), izinkinga zamehlo, kufaka phakathi izinguquko noma ukulahleka kombono, noma isifo sezinsini. Udokotela wakho nabanye abahlinzeki bezokunakekelwa kwezempilo bazokhuluma nawe ngendlela engcono yokuphatha isifo sikashukela.

IDapagliflozin iza njengethebhulethi ezothathwa ngomlomo. Kuthathwa ngokujwayelekile ngokudla noma ngaphandle kokudla kanye ngosuku ekuseni. Thatha i-dapagliflozin ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-dapagliflozin njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Udokotela wakho angakuqala ngomthamo ophansi we-dapagliflozin futhi akhuphule umthamo wakho uma kudingeka.

IDapagliflozin ilawula uhlobo lwesifo sikashukela esingu-2 kodwa ayiselaphi. Qhubeka uthathe i-dapagliflozin noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-dapagliflozin ngaphandle kokukhuluma nodokotela wakho.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-dapagliflozin futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ukuthola uMhlahlandlela Wezokwelapha.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-dapagliflozin,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-dapagliflozin, noma imiphi eminye imithi, noma iziphi izithako ezikumaphilisi e-dapagliflozin. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: i-angiotensin-converting enzyme (ACE) inhibitors efana ne-benazepril (Lotensin, eLotrel), i-captopril, i-enalapril (i-Vasotec, e-Vaseretic), i-fosinopril, i-lisinopril (e-Zestoretic), i-moexipril (Univasc, Uniretic), perindopril (Aceon, in Prestalia), ramipril (Altace), kanye ne-trandolapril (Mavik, eTarka); ama-angiotensin receptor blockers (ARB) afana ne-azilsartan (Edarbi, e-Edarbyclor), candesartan (Atacand, e-Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, e-Avalide), losartan (Cozaar, e-Hyzaar), olmesartan (Benicar, e-Azor, e-Benicar HCT, e-Tribenzor), e-telmisartan (Micardis, e-Micardis HCT, e-Twynsta); i-aspirin neminye imishanguzo yokulwa nokuvuvukala (i-NSAIDS) efana ne-ibuprofen (Advil, Motrin) ne-naproxen (Aleve, Naprosyn); imithi yesifo sikashukela efana ne-glimepiride (Amaryl, e-Duetact), i-glipizide (Glucotrol), i-glyburide (i-DiaBeta, i-Glynase), i-repaglinide (i-Prandin, e-Prandimet), ne-tolbutamide; isisu (‘amaphilisi amanzi’); kanye ne-insulin.
• utshele udokotela wakho uma uku-dialysis nokuthi unesifo sezinso noma wake waba nesifo sezinso. Udokotela wakho angakutshela ukuthi ungathathi i-dapagliflozin.
• tshela udokotela wakho uma uphuza njalo utshwala noma kwesinye isikhathi uphuza utshwala obuningi ngesikhathi esifushane (ukuzitika ngotshwala) noma uma udla ukudla okunesodium okuncane. Tshela nodokotela wakho uma ngabe uke wahluleka yinhliziyo, isifo se-pancreatic kubandakanya i-pancreatitis (ukuvuvukala kwamanyikwe) noma uke wahlinzwa amanyikwe, izifo ezithinta umchamo noma izinkinga zokuchama, umfutho ophansi wegazi, ukutheleleka ngemvubelo endaweni yangasese, isifo sezinso noma sesibindi. Uma ungowesilisa, tshela udokotela wakho uma ungakaze usokwe. Tshela nodokotela wakho, uma ngabe udla kancane ngenxa yokugula, ukuhlinzwa noma ushintsho ekudleni kwakho, noma usanda kuba nohudo, uhlanza, ubungaphuzi uketshezi olwanele, uhlale elangeni isikhathi eside kakhulu, noma ubulokhu ujuluka kakhulu, okungadala ukoma (ukulahleka kwenqwaba yoketshezi lomzimba).
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Ungancelisi ibele ngenkathi uthatha i-dapagliflozin. Uma ukhulelwa ngenkathi uthatha i-dapagliflozin, shayela udokotela wakho.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-dapagliflozin. Udokotela wakho mhlawumbe uzokutshela ukuthi uyeke ukuthatha i-dapagliflozin okungenani izinsuku ezintathu ngaphambi kokuhlinzwa.
• utshwala bungadala ushintsho kushukela wegazi. Buza udokotela wakho mayelana nokusetshenziswa okuphephile kweziphuzo ezidakayo ngenkathi uthatha i-dapagliflozin.
• kufanele wazi ukuthi i-dapagliflozin ingadala isiyezi, ikhanda elikhanyayo, nokuquleka lapho uvuka ngokushesha okukhulu endaweni yokulala. Uma unale nkinga, shayela udokotela wakho. Le nkinga ivame kakhulu lapho uqala ukuthatha i-dapagliflozin. Ukugwema le nkinga, phuma embhedeni kancane, uphumule izinyawo zakho phansi imizuzu embalwa ngaphambi kokuma.
• buza udokotela wakho ukuthi yini okufanele uyenze uma ugula, uba nesifo noma umkhuhlane, uba nengcindezi engajwayelekile, noma ulimele. Lezi zimo zingathinta ushukela wegazi lakho kanye nenani le-dapagliflozin ongayidinga.

Qiniseka ukuthi ulandela zonke izincomo zokuzivocavoca nezokudla ezenziwa ngudokotela wakho noma udokotela odlayo. Kubalulekile ukudla ukudla okunempilo nokuvivinya umzimba njalo.

Landela imiyalo kadokotela wakho mayelana nokuphuza uketshezi olwanele usuku lonke ngenkathi ukule mithi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

Lo muthi ungadala ushintsho kushukela wakho wegazi. Kufanele wazi izimpawu zikashukela wegazi ophansi futhi ophakeme nokuthi yini okufanele uyenze uma unalezi zimpawu.

I-Dapagliflozin ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuchama kakhulu, kufaka phakathi nasebusuku
• ukoma okwandisiwe

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• ukuchama njalo, okuphuthumayo, okushisayo, noma okubuhlungu
• umchamo onamafu, obomvu, opinki, noma onsundu
• umchamo onukayo onamandla
• ukuncipha kwenani lomchamo
• ubuhlungu be-pelvic noma be-rectal
• (kwabesifazane) iphunga lesitho sangasese sowesifazane, ukuphuma okumhlophe noma okuphuzi kwesitho sangasese sowesifazane (kungaba nesigaxa noma kubukeke njenge-cottage shizi), noma ukulunywa kwesitho sangasese sowesifazane
• (emadodeni) ububomvu, ukulunywa, noma ukuvuvukala kwenduku; ukuqhuma emthondweni; ukukhishwa okunuka kabi okuvela epeni; noma ubuhlungu esikhunjeni esizungeze ipipi
• ukuzizwa ukhathele, ubuthakathaka, noma ungakhululekile; kanye nomkhuhlane nobuhlungu, isisa, ubomvu, nokuvuvukala kwezitho zangasese noma indawo ephakathi kwezitho zangasese kanye nengxenyeni
• ukuvuvukala kwemilenze noma izinyawo

Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, yeka ukuthatha i-dapagliflozin bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuqubuka
• isifuba
• ukulunywa
• ukuphefumula kanzima noma ukugwinya
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe, umlomo, noma amehlo
• ukushaqeka

Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo ze-ketoacidosis, yeka ukuthatha i-dapagliflozin bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo. Uma kunokwenzeka, hlola ama-ketone emchameni wakho uma unalezi zimpawu, noma ngabe ushukela wegazi lakho ungaphansi kuka-250 mg / dL:

• isicanucanu
• ukuhlanza
• ubuhlungu bendawo esiswini
• ukukhathala
• ukuphefumula kanzima

I-Dapagliflozin ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho mhlawumbe uzo-oda izivivinyo ezithile zaselebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-dapagliflozin.

Amazinga kashukela egazini lakho kufanele ahlolwe njalo ukuthola impendulo yakho ku-dapagliflozin. Udokotela wakho uzo-oda ezinye izivivinyo zelebhu, kufaka phakathi i-hemoglobin ye-glycosylated (HbA1c), ukuhlola impendulo yakho ku-dapagliflozin. Udokotela wakho uzokutshela nokuthi ungayihlola kanjani impendulo yakho kulo muthi ngokulinganisa amazinga kashukela egazini lakho ekhaya. Landela le miyalo ngokucophelela.

Ngaphambi kokwenza noma yiluphi uvivinyo lwelabhoratri, tshela udokotela wakho kanye nabasebenzi belebhuthi ukuthi uthatha i-dapagliflozin. Ngenxa yendlela osebenza ngayo lo muthi, umchamo wakho ungahlola ukuthi une-glucose.

Kufanele njalo ufake isongo lokuhlonza isifo sikashukela ukuze uqiniseke ukuthi uthola ukwelashwa okufanele esimeni esiphuthumayo.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Farxiga^®

• Qtern^® (equkethe iDapagliflozin, Saxagliptin)
• Qternmet^® I-XR (equkethe iDapagliflozin, Metformin, Saxagliptin)
• Xigduo^® I-XR (equkethe iDapagliflozin, Metformin)