Inaliti yeRamucirumab

-Delile

• Ngaphambi kokuthola umjovo we-ramucirumab,
• Umjovo weRamucirumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

Umjovo weRamucirumab usetshenziswa wedwa futhi uhlanganiswe nomunye umuthi wokwelapha ngamakhemikhali ukwelapha umdlavuza wesisu noma umdlavuza osendaweni lapho isisu sihlangana khona nomphimbo (ishubhu eliphakathi komphimbo nesisu) lapho lezi zimo zingathuthuki ngemuva kokwelashwa neminye imithi. I-Ramucirumab isetshenziswa futhi ngokuhlangana ne-docetaxel ukwelapha uhlobo oluthile lomdlavuza wamaphaphu weseli ongesona omncane (i-NSCLC) osabalalele kwezinye izingxenye zomzimba kubantu asebelashwe ngeminye imishanguzo yamakhemikhali futhi abangazange bathuthuke noma babe babi kakhulu. Isetshenziswa futhi ngokuhlangana ne-erlotinib (Tarceva) kuhlobo oluthile lwe-NSCLC eselusabalalele kwezinye izingxenye zomzimba. I-Ramucirumab isetshenziswa futhi ngokuhlangana neminye imishanguzo yokwelapha ngamakhemikhali ukwelapha umdlavuza wekholoni (amathumbu amakhulu) noma i-rectum esabalele kwezinye izingxenye zomzimba kubantu asebevele belashwa ngeminye imishanguzo ye-chemotherapy futhi abangazange bathuthuke noma babe babi kakhulu. I-Ramucirumab isetshenziswa yodwa ukwelapha abantu abathile abane-hepatocellular carcinoma (HCC; uhlobo lomdlavuza wesibindi) asebevele belashwa nge-sorafenib (Nexafar). URamucirumab usesigabeni semithi ebizwa ngama-antibody monoclonal. Isebenza ngokumisa ukukhula kwamangqamuzana omdlavuza.

Umjovo weRamucirumab uza njengoketshezi oluzofakwa emthanjeni ngaphezu kwemizuzu engama-30 noma engama-60 ngudokotela noma umhlengikazi esibhedlela noma esikhungweni sezokwelapha. Ukwelashwa komdlavuza wesisu, umdlavuza wekoloni noma i-rectum, noma i-HCC, kuvame ukunikezwa kanye njalo emavikini amabili. Ekwelapheni i-NSCLC kanye ne-erlotinib, i-ramucirumab ivame ukunikezwa kanye njalo emavikini amabili. Ekwelapheni i-NSCLC kanye ne-docetaxel, i-ramucirumab ivame ukunikezwa kanye njalo emavikini amathathu. Ubude bokwelashwa kwakho buncike ekutheni umzimba wakho uphendula kahle kanjani emithini nasemiphumeleni oyitholayo.

Udokotela wakho angadinga ukuphazamisa noma ayeke ukwelashwa kwakho uma uhlangabezana nemiphumela ethile emibi. Udokotela wakho uzokunika eminye imithi yokuvikela noma yokwelapha imiphumela ethile engemihle ngaphambi kokuba uthole umjovo ngamunye womjovo we-ramucirumab. Tshela udokotela wakho noma umhlengikazi uma uhlangabezana nanoma ikuphi kwalokhu okulandelayo ngenkathi uthola i-ramucirumab: ukuzamazama okungalawuleki kwengxenye yomzimba; ubuhlungu beqolo noma ama-spasms; ubuhlungu besifuba nokuqina; Ukugodola; ukuqhuma; ukuphelelwa umoya; ukushaya; ubuhlungu, ukushisa, ukuba ndikindiki, ukubhoboza, noma ukuhayiza ezandleni noma ezinyaweni noma esikhunjeni; ubunzima bokuphefumula; noma ukushaya kwenhliziyo okusheshayo.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-ramucirumab,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-ramucirumab noma eminye imithi noma enye yezithako zomjovo we-ramucirumab. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi uke waba nomfutho wegazi ophakeme noma unesifo se-thyroid noma sesibindi. Tshela nodokotela wakho uma unesilonda esingakapholi okwamanje, noma uma uba nesilonda ngesikhathi sokwelashwa esingapholi kahle.
• kufanele wazi ukuthi i-ramucirumab ingadala ukungabi nenzalo kwabesifazane (kunzima ukukhulelwa); noma kunjalo, akufanele ucabange ukuthi awukwazi ukukhulelwa. Tshela udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Kufanele uhlolwe ukukhulelwa ngaphambi kokuqala ukwelashwa. Kufanele usebenzise ukulawulwa kokubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho futhi okungenani izinyanga ezintathu ngemuva kokwelashwa kwakho kokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ukhulelwa ngesikhathi sokwelashwa kwakho ngomjovo we-ramucirumab, shayela udokotela wakho ngokushesha. URamucirumab angalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngesikhathi sokwelashwa kwakho nge-ramucirumab kanye nezinyanga ezimbili ngemuva komthamo wakho wokugcina.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthola umjovo we-ramucirumab. Udokotela wakho angakutshela ukuthi ungawutholi umjovo we-ramucirumab phakathi nezinsuku ezingama-28 ngaphambi kokuhlinzwa kwakho. Ungavunyelwa ukuqala kabusha ukwelashwa ngomjovo we-ramucirumab uma okungenani kungakapheli izinsuku eziyi-14 ukuhlinzwa kwakho nesilonda selulama.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Shayela udokotela wakho ngokushesha uma ungakwazi ukugcina i-aphoyintimenti yokuthola umthamo womjovo we-ramucirumab.

Umjovo weRamucirumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• izilonda emlonyeni noma emphinjeni

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• ukuqubuka
• ubuthakathaka obungazelelwe bengalo noma bomlenze
• ukujula kolunye uhlangothi lobuso
• kunzima ukukhuluma noma ukuqonda
• ubuhlungu besifuba noma behlombe
• inkulumo ehamba kancane noma enzima
• ubuhlungu besifuba
• ukuphelelwa umoya
• ikhanda
• isiyezi noma ukuquleka
• isithuthwane
• ukudideka
• ushintsho kumbono noma ukulahleka kombono
• ukukhathala ngokweqile
• ukuvuvukala kobuso, amehlo, isisu, izandla, izinyawo, amaqakala noma imilenze engezansi
• ukuzuza kwesisindo okungaqondakali
• umchamo onamagwebu
• umphimbo obuhlungu, umkhuhlane, amakhaza, ukukhwehlela okuqhubekayo nokucinana, noma ezinye izimpawu zokutheleleka
• ukukhwehlela noma ukugabha igazi noma okokusebenza okubukeka njengezizathu zekhofi, ukuphuma okungavamile noma ukulimaza, umchamo obomvana, obomvu, noma onsundu, ukunyakaza kwamathumbu abomvu noma okulindile
• uhudo, ukuhlanza, ubuhlungu besisu, umkhuhlane, noma ukugodola

Umjovo weRamucirumab ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi usebenzisa lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Kwezinye izimo, udokotela wakho angayalela ukuhlolwa kwelebhu ngaphambi kokuba uqale ukwelashwa kwakho ukubona ukuthi umdlavuza wakho ungelashwa nge-ramucirumab. Udokotela wakho uzohlola umfutho wegazi lakho futhi avivinye umchamo wakho njalo lapho welashwa nge-ramucirumab.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UCyramza^®