Idelalisib

-Delile

• Ngaphambi kokuthatha idelalisib,
• I-Idelalisib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Idelalisib ingadala ukulimala kwesibindi okubi noma okusongela impilo. Tshela udokotela wakho uma uke waba nesifo sesibindi noma wake waba naso. Ingozi yokulimala kwesibindi ingakhuphuka kubantu abathatha eminye imishanguzo eyaziwa ngokudala ukulimala kwesibindi, nakubantu asebavele benesifo sesibindi. Tshela udokotela wakho kanye nosokhemisi ngemithi oyiphuzayo ukuze bakwazi ukubheka ukuthi ngabe ikhona yini imishanguzo yakho engakhuphula ubungozi bokuthi uzoba nokulimala kwesibindi ngenkathi welashwa nge-idelalisib. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukukhathala ngokweqile, ukulahlekelwa isifiso sokudla, ukuncipha komzimba, isicanucanu, ukuhlanza, ukopha okungavamile noma ukulimaza, ukuphuzi kwesikhumba noma kwamehlo, umchamo omnyama ophuzi noma onsundu, izihlalo eziphaphathekile , noma ubuhlungu engxenyeni engaphezulu kwesokudla yesisu.

I-Idelalisib ingadala isifo sohudo, i-colitis (ukuvuvukala kwamathumbu amakhulu), noma izimbobo esiswini noma emathunjini. Tshela udokotela wakho uma unesifo sohudo noma uma uke waba nesifo sokudlikiza noma ezinye izimo ezithinta isisu noma amathumbu akho. Ingozi yohudo ingakhuphuka kubantu abathatha eminye imishanguzo eyaziwa ngokubangela isifo sohudo. Tshela udokotela wakho kanye nosokhemisi ngemithi oyiphuzayo ukuze bakwazi ukubheka ukuthi ngabe imiphi imithi yakho ingakhuphula ubungozi bokuthi uzoba nohudo ngesikhathi ukwelashwa kwakho nge-idelalisib. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: uma inani lakho lokuhamba kwamathumbu ngosuku lenyuka ngo-6 noma ngaphezulu, isisu noma izinhlungu, ukugodola, umkhuhlane, isicanucanu, noma ukugabha.

I-Idelalisib ingadala i-pneumonitis ebucayi noma esongela impilo (ukuvuvukala kwamaphaphu). Tshela udokotela wakho uma unesifo samaphaphu noma unenkinga yokuphefumula. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukukhwehlela okusha noma okuya kuba kubi, ukuphefumula kanzima, ukuphefumula, noma ukuphefumula okuncane.

I-Idelalisib ingadala izifo ezinzima noma ezisongela impilo. Tshela udokotela wakho uma unesifo, noma uma uke waba ne-cytomegalovirus (CMV; ukutheleleka ngegciwane okungadala izimpawu ezigulini ezinamasosha omzimba abuthakathaka). Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: umkhuhlane, umphimbo obuhlungu, amakhaza, ubuhlungu, ukuchama kaningi, noma ubunzima, noma ezinye izimpawu zokutheleleka.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ukuze ahlole impendulo yomzimba wakho ku-idelalisib.

Khuluma nodokotela wakho ngezingozi zokuthatha i-idelalisib.

I-Idelalisib isetshenziswa kanye nomunye umuthi i-rituximab (Rituxan) ukwelapha i-lymphocytic leukemia (CLL; uhlobo lomdlavuza oqala kumaseli amhlophe egazi) kubantu abanomdlavuza obuyile ngemuva kokuthola ezinye izindlela zokwelashwa komdlavuza. Ibuye isetshenziselwe ukwelapha izinhlobo ezithile ze-follicular lymphoma (FL; uhlobo lomdlavuza oluqala kumaseli amhlophe egazi) kanye ne-lymphocytic lymphoma (SLL: uhlobo lomdlavuza oqala kumaseli amhlophe egazi) kubantu abanomdlavuza owafika emuva ngemuva kokuphathwa okungenani ezinye izindlela zokwelashwa ezimbili zomdlavuza. U-Idelalisib usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba ukusebenza kweprotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunqanda ukusabalala kwamangqamuzana omdlavuza.

U-Idelalisib uza njengethebhulethi azoyithatha ngomlomo. Imvamisa kuthathwa ngokudla noma ngaphandle kokudla kabili ngosuku. Thatha idelalisib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-idelalisib njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Udokotela wakho anganciphisa umthamo wakho we-idelalisib noma akutshele ukuthi uyeke ukuthatha umuthi isikhashana noma unomphela uma uba nemiphumela emibi ngesikhathi sokwelashwa kwakho. Lokhu kuncike ekutheni umuthi usebenza kanjani kuwe kanye nemiphumela emibi oyitholayo. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Qhubeka uthathe i-idelalisib noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-idelalisib ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha idelalisib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-idelalisib, noma imuphi omunye umuthi, noma iziphi izithako ezibhebheni ze-idelalisib. Uma ngabe uke waphathwa kabi emzimbeni esikhathini esedlule, njengokuvuvukala kobuso bakho, izindebe noma umphimbo; ubunzima bokugwinya noma ukuphefumula; noma uxebuka, isikhumba esikhanyayo, udokotela wakho uzokutshela ukuthi ungathathi i-idelalisib.Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: carbamazepine (Carbatrol, Epitol, Equetro, abanye); i-clarithromycin (i-Biaxin, ku-PrevPac); itraconazole (Onmel, Sporanox); ketoconazole (Nizoral); imishanguzo esetshenziselwa ukwelapha igciwane lengculazi (i-HIV) njenge-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, eKaletra, e Technivie); i-midazolam; nefazodone; i-phenobarbital; i-phenytoin (iDilantin, Phenytek); i-pioglitazone (Actos, e-Actoplus Met, eDuetact, e-Oseni); i-rifabutin (i-Mycobutin); kanye ne-rifampin (Rifadin, Rimactane, eRifamate, eRifater). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingase futhi ihlanganyele ne-idelalisib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• utshele udokotela wakho kanye nosokhemisi ukuthi yimiphi imikhiqizo yamakhambi oyithathayo, ikakhulukazi iSort John's wort. Akufanele uthathe i-wort yaseSt. John ngesikhathi sokwelashwa kwakho nge-idelalisib.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uhlele ukuba nobaba wengane. Akufanele ukhulelwe ngesikhathi sokwelashwa kwakho nge-idelalisib.Kufanele usebenzise ukulawulwa kokuzalwa ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nge-idelalisib futhi okungenani inyanga eyodwa ngemuva komthamo wakho wokugcina. Uma ungowesilisa futhi umlingani wakho angakhulelwa, kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho nezinyanga ezi-3 ngemuva komthamo wakho wokugcina. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-idelalisib, shayela udokotela wakho ngokushesha. U-Idelalisib angalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngenkathi uthatha i-idelalisib futhi okungenani inyanga eyodwa ngemuva komthamo wakho wokugcina.

Khuluma nodokotela wakho ngokudla isithelo samagilebhisi nokuphuza ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Uma uphuthelwa umthamo we-idelalisib ngaphansi kwamahora ayisithupha, thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula bese uthatha umthamo olandelayo ngesikhathi esihleliwe. Kodwa-ke, uma uphuthelwa umthamo ngaphezu kwamahora we-6, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Idelalisib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• ubunzima bokulala noma ukulala
• ukuncipha kokudla
• ukoma okwandisiwe
• isilungulela
• ubuhlungu obuhlangene
• ukujuluka ebusuku
• ukungabi namandla
• ukuvuvukala kwezandla, izinyawo, amaqakala, noma imilenze engezansi

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• isikhumba esibomvu, sokuluma, sokuxebuka, noma sokushwabana
• izilonda noma izilonda esikhumbeni, ezindebeni, noma emlonyeni wakho
• ubunzima bokugwinya noma ukuphefumula; ukuvuvukala kobuso, izindebe, noma umphimbo; isifuba; ukulunywa

I-Idelalisib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Ukugcine ekamelweni lokushisa kude nokukhanya, ukushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Zydelig^®