Inaliti ye-Blinatumomab

-Delile

• Ngaphambi kokuthola umjovo we-blinatumomab,
• Umjovo we-Blinatumomab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe ezigabeni EZIBALULEKILE ZESEXWAYISO noma ZOKUQAPHA, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

Umjovo we-Blinatumomab kufanele unikezwe kuphela ngaphansi kokuqondisa kukadokotela onolwazi ekusetshenzisweni kwemithi yokwelapha ngamakhemikhali.

Umjovo we-Blinatumomab ungadala ukusabela okungathi sína, okusongela ukuphila okungenzeka ngesikhathi sokufakwa kwalomuthi. Tshela udokotela wakho uma ngabe uke waphendula nge-blinatumomab noma omunye umuthi. Uzothola imithi ethile yokusiza ukuvimbela ukusabela okweqile ngaphambi kokuthola umthamo ngamunye we-blinatumomab. Uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi noma ngemuva kokuthola i-blinatumomab, tshela udokotela wakho ngokushesha: umkhuhlane, ukukhathala, ubuthakathaka, isiyezi, ikhanda elibuhlungu, isicanucanu, ukuhlanza, ukugodola, ukuqubuka, ukuvuvukala kobuso, ukuphefumula, noma ukuphefumula kanzima. Uma uhlangabezana nokusabela okunzima, udokotela wakho uzomisa ukumnika kwakho futhi aphathe izimpawu zokuphendula.

Umjovo we-Blinatumomab nawo ungadala ukusabela okubucayi, okusongela ukuphila kohlelo oluphakathi lwezinzwa. Tshela udokotela wakho uma ngabe uke wahlaselwa noma wadideka, wadideka, walahlekelwa ibhalansi, noma unenkinga yokukhuluma. Uma uhlangabezana nalezi zimpawu ezilandelayo, tshela udokotela wakho ngokushesha: ukuquleka, ukuqhaqhazela okungalawuleki kwengxenye yomzimba, ukukhuluma kanzima, ukukhuluma okungaqondakali, ukulahlekelwa ukwazi, ubunzima bokulala noma ukulala, ikhanda elibuhlungu, ukudideka noma ukulahlekelwa ibhalansi .

Khuluma nodokotela wakho ngobungozi (s) bokusebenzisa umjovo we-blinatumomab.

I-Blinatumomab isetshenziselwa abantu abadala nezingane ukuphatha izinhlobo ezithile ze-acute lymphocytic leukemia (BONKE; uhlobo lomdlavuza wamaseli amhlophe egazi) ongakatholi ngcono, noma obuyile ngemuva kokwelashwa ngeminye imithi. I-Blinatumomab nayo isetshenziswa kubantu abadala nasezinganeni ukwelapha KONKE okuxolelwe (ukwehla noma ukunyamalala kwezimpawu nezimpawu zomdlavuza), kepha obunye ubufakazi bomdlavuza busekhona. UBlinatumomab usesigabeni semithi ebizwa ngama-bispecific T-cell Invr antibodies. Isebenza ngokunciphisa noma ukumisa ukukhula kwamangqamuzana omdlavuza emzimbeni wakho.

UBlinatumomab uza njengempuphu ezohlanganiswa noketshezi oluzofakwa kancane ngaphakathi (emthanjeni) ngudokotela noma umhlengikazi esibhedlela noma esikhungweni sezokwelapha kwesinye isikhathi nasekhaya. Lo muthi unikezwa ngokuqhubekayo amasonto ama-4 alandelwe amasonto ama-2 kuye kwayi-8 lapho umuthi unganikezwa. Le nkathi yokwelashwa ibizwa ngokuthi umjikelezo, futhi umjikelezo ungaphindwa lapho kudingeka. Ubude bokwelashwa buya ngokuthi uphendula kanjani emithini.

Udokotela wakho angadinga ukubambezela ukwelashwa kwakho, ukushintsha umthamo wakho, noma ukumisa ukwelashwa kwakho uma uhlangabezana nemiphumela ethile emibi. Kubalulekile ukuthi utshele udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa ngomjovo we-blinatumomab.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-blinatumomab,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-blinatumomab, noma imiphi eminye imithi, i-benzyl alcohol. noma ezinye izithako zomjovo we-blinatumomab. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-cyclosporine (Gengraf, Neoral, Sandimmune) noma warfarin (Coumadin, Jantoven). Eminye imithi eminingi ingase futhi ihlanganyele ne-blinatumomab, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma unesifo noma ngabe uke waba nokutheleleka okuhlala kubuya. Futhi, tshela udokotela wakho uma ngabe uke welashwa ngemisebe ebuchosheni noma uthole ukwelashwa ngamakhemikhali noma wake waba nesifo sesibindi.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uzodinga ukuhlolwa kokukhulelwa ngaphambi kokuthola le mithi. Akufanele ukhulelwe ngenkathi welashwa nge-blinatumomab futhi okungenani izinsuku ezimbili ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezinhlobo zokulawulwa kokuzalwa okuzokusebenzela. Uma ukhulelwa ngenkathi usebenzisa i-blinatumomab, shayela udokotela wakho. I-Blinatumomab ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Ungancelisi ibele ngenkathi uthola i-blinatumomab futhi okungenani izinsuku ezimbili ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi umjovo we-blinatumomab ungakwenza ukozele. Ungashayeli imoto noma usebenzise imishini ngenkathi uthola lo muthi.
• ungenayo imigomo ngaphandle kokukhuluma nodokotela wakho. Tshela udokotela wakho uma uthole umuthi wokugoma emavikini amabili edlule. Ngemuva komthamo wakho wokugcina, udokotela wakho uzokutshela ukuthi kuphephile nini ukuthola umuthi wokugoma.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Umjovo we-Blinatumomab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuqunjelwa
• isifo sohudo
• ukuzuza kwesisindo
• iqolo, ukuhlangana, noma ubuhlungu bemisipha
• ukuvuvukala kwezingalo, izandla, izinyawo, amaqakala, noma imilenze engezansi
• ubuhlungu endaweni yomjovo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe ezigabeni EZIBALULEKILE ZESEXWAYISO noma ZOKUQAPHA, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ubuhlungu besifuba
• ukuba ndikindiki noma ukuncinza ezingalweni, emilenzeni, ezandleni noma ezinyaweni
• ukuphelelwa umoya
• ubuhlungu obuqhubekayo obuqala endaweni yesisu kepha bungasabalala buye emuva okungenzeka noma ngaphandle kwesicanucanu nokuhlanza
• umkhuhlane, umphimbo obuhlungu, ukukhwehlela, nezinye izimpawu zokutheleleka

Umjovo we-Blinatumomab ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• imfiva
• ukuzamazama okungalawuleki kwengxenye yomzimba
• ikhanda

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi, ngesikhathi, nangemva kokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho kumjovo we-blinatumomab nokwelapha imiphumela engemihle ngaphambi kokuba ibe mibi.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Blincyto^®