UNintedanib

-Delile

• Ngaphambi kokuthatha i-nintedanib,
• INintedanib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

INintedanib isetshenziselwa ukwelapha idiopathic pulmonary fibrosis (IPF; scarring of the lungs with an unknown cause). Ibuye isetshenziselwe ukwelapha izinhlobo ezithile zezifo zamaphaphu ezingapheli (i-ILD; isifo esiqhubekayo lapho kukhona ukwanda kwamaphaphu). INintedanib ibuye isetshenziselwe ukwehlisa izinga lokwehla kokusebenza kwamaphaphu kubantu abane-systemic sclerosis-associated interstitial lung disease (SSc-ILD; esaziwa nangokuthi yi-scleroderma-associated ILD: isifo lapho kunokubaba kwamaphaphu okuvame ukubulala ). UNintedanib usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba ukusebenza kwama-enzyme abandakanyeka ekudaleni i-fibrosis.

UNintedanib uza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa ngokudla njalo emahoreni ayi-12 (kabili ngosuku). Thatha amaphilisi we-nintedanib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-nintedanib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi ngoketshezi; ungawahlafune noma uwachoboze.

Udokotela wakho angadinga ukwehlisa umthamo wakho noma ayeke ukwelashwa uma uhlangabezana nemiphumela emibi ethile. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-nintedanib,

• Tshela udokotela kanye nosokhemisi wakho uma une-allergic ku-nintedanib, noma imiphi eminye imithi, noma iziphi izithako ezikuma-capsules we-nintedanib Buza usokhemisi wakho noma hlola imininingwane yesiguli somkhiqizi ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: ama-anticoagulants (’’ ama-thinner egazi ’’) afana ne-warfarin (Coumadin, Jantoven); i-aspirin nezinye izidakamizwa ezingezona ukuvuvukala (i-NSAIDS) ezifana ne-ibuprofen (Advil, Motrin, ezinye) ne-naproxen (i-Aleve, i-Anaprox, iNaprelan); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); i-erythromycin (i-EES, i-Ery-Tab, i-Eryc); ketoconazole; laxatives; i-steroids yomlomo efana ne-dexamethasone (i-Decadron, i-Dexpak), i-methylprednisolone (i-Medrol) ne-prednisone; i-phenytoin (iDilantin, Phenytek); i-pirfenidone (i-Esbriet); i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); noma izithambisi zendle. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma wena noma omunye emndenini wakho eke waba nenkinga yokopha, uma ngabe uke waba nesifo sesibindi noma senhliziyo, isifo se-diverticular (diverticulitis; izikhwama ezincane emgodini wamathumbu amakhulu angavuvukala), noma amahlule egazi, futhi uma ngabe uke wahlinzwa isisu muva nje.
• Tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma kungenzeka ukhulelwe. Akufanele uqale ukuthatha i-nintedanib kuze kube yilapho ukuhlolwa kokukhulelwa kukhombisa ukuthi awukhulelwe. Akufanele ukhulelwe ngenkathi uthatha i-nintedanib; umuthi ungalimaza ingane yakho engakazalwa. INintedanib inganciphisa ukusebenza kahle kwezindlela zokuvimbela inzalo ngamahomoni (amaphilisi okulawula ukubeletha, amabala, izindandatho, okufakelwa emzimbeni noma imijovo), ngakho-ke akufanele uzisebenzise njengendlela yakho yokulawula inzalo kuphela. Kufanele futhi usebenzise indlela yokuvimbela inzalo (idivaysi evimba isidoda ukuthi singene esibelethweni njengekhondomu noma idayaphragm). Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho futhi okungenani izinyanga ezintathu ngemuva komthamo wakho wokugcina we-nintedanib. Uma ukhulelwa ngenkathi uthatha i-nintedanib, shayela udokotela wakho ngokushesha.
• tshela udokotela wakho uma uncelisa.
• utshele udokotela wakho uma usebenzisa imikhiqizo kagwayi. Ukubhema ugwayi kunganciphisa ukusebenza kwalo muthi. Kufanele uyeke ukubhema ngaphambi kokuthi uqale ukuthatha i-nintedanib futhi ugweme ukubhema ngesikhathi sokwelashwa kwakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa umthamo we-nintedanib, weqa umthamo ongabanjwanga bese uqhubeka nesimiso sakho esijwayelekile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

INintedanib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• ukuncipha kokudla
• ukuncipha komzimba

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• isifo sohudo
• ukukhathala ngokweqile
• ukopha okungajwayelekile noma ukulinyazwa
• ukungabi namandla
• ukulahlekelwa isifiso sokudla
• ubuhlungu engxenyeni engenhla kwesokudla yesisu
• ukuphuzi kwesikhumba noma kwamehlo
• umchamo omnyama noma onsundu (ombala wetiye)
• ubuhlungu besifuba
• ubuhlungu ezingalweni zakho, emuva, entanyeni, noma emhlathini
• ukuphelelwa umoya
• ukuba ndikindiki noma ubuthakathaka ohlangothini olulodwa lomzimba wakho
• kunzima ukukhuluma
• ikhanda
• isiyezi
• amanxeba angapholi
• ubuhlungu noma ukuvuvukala esiswini sakho, isicanucanu, ukuhlanza, umkhuhlane, amakhaza, noma igazi esitulweni sakho
• ukuqubuka
• ukulunywa

INintedanib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-nintedanib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Ofev^®