Inaliti ye-Alirocumab

-Delile

• Ngaphambi kokusebenzisa umjovo we-alirocumab,
• Umjovo we-Alirocumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukusebenzisa umjovo we-alirocumab bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Umjovo we-Alirocumab usetshenziswa kanye nokudla, kukodwa noma kuhlanganiswe neminye imishanguzo yokwehlisa i-cholesterol (HMG-CoA reductase inhibitors [statins] noma ezetimibe [Zetia, eLiptruzet, eVytorin]), kubantu abadala abane-hypercholesterolemia ye-heterozygous yomndeni. isimo lapho i-cholesterol ingeke isuswe emzimbeni ngokujwayelekile) ukwehlisa inani le-cholesterol enesisindo esiphansi (LDL) ('cholesterol embi') egazini. Umjovo we-Alirocumab uyasetshenziswa nakubantu abadala abanesifo senhliziyo ukwehlisa ubungozi bokushaywa unhlangothi, isifo senhliziyo, noma ubuhlungu besifuba obubi noma obusongela impilo. Umjovo we-Alirocumab usesigabeni semithi ebizwa ngeproprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor monoclonal antibodies. Isebenza ngokuvimba ukukhiqizwa kwe-cholesterol ye-LDL emzimbeni ngakho-ke kunciphisa inani le-cholesterol engakha ezindongeni zemithambo.

Ukuqoqeka kwecholesterol ezindongeni zemithambo yakho (inqubo eyaziwa njenge-atherosclerosis) kunciphisa ukugeleza kwegazi, ngakho-ke, ukunikezwa komoya-mpilo enhliziyweni yakho, ebuchosheni nakwezinye izingxenye zomzimba wakho.

Umjovo we-Alirocumab uza njengesisombululo (uketshezi) kusirinji ekhethiwe kanye nepeni lokufaka elithandwayo ukujova ngomgogodla (ngaphansi kwesikhumba) kanye njalo emavikini ama-2 noma ama-4. Sebenzisa umjovo we-alirocumab ngasikhathi sinye njalo emavikini ama-2 noma ama-4. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Sebenzisa umjovo we-alirocumab njengoba uqondisiwe. Ungawusebenzisi kakhulu lo muthi noma uwusebenzise kaningi noma isikhathi eside kunokuyalelwa ngudokotela wakho.

Ngemuva kwamasonto amane kuya kwangu-8 okwelashwa, udokotela wakho angakhuphula umthamo wakho ngokuya ngempendulo yakho kulo muthi.

Umjovo we-Alirocumab usiza ukulawula amazinga e-cholesterol, kepha ayizelaphi lezi zimo. Qhubeka nokusebenzisa umjovo we-alirocumab noma ngabe uzizwa uphilile. Ungayeki ukusebenzisa umjovo we-alirocumab ngaphandle kokukhuluma nodokotela wakho.

Umjovo we-Alirocumab ufika ezibayeni zokufaka ezikhethiwe kanye nemijovo ekhethiwe equkethe imishanguzo eyanele yedosi elilodwa. Uma udokotela wakho ekutshela ukuthi udinga ukusebenzisa ipeni noma isirinji engaphezu kwesisodwa kumthamo wakho, sebenzisa amapeni noma imijovo ngokulandelana kokungena ezindaweni ezihlukene zomjovo. Kungathatha amasekhondi afinyelela kwangu-20 ukujova umuthi. Njalo jovela i-alirocumab ngepeni noma ngomjovo wayo owuthandayo; ungalinge uyixube nomunye umuthi. Lahla izinaliti, imijovo nezinto ezisetshenzisiwe esitsheni esingamelana nokubhoboza; ungalokothi uphinde usebenzise ipeni noma isirinji. Khuluma nodokotela wakho noma usokhemisi mayelana nokuthi ungasilahla kanjani isitsha esingamelana nokubhoboza.

Ungafaka umjovo we-alirocumab ethangeni lakho, ezingalweni ezingenhla, noma endaweni yesisu, ngaphandle kwendawo engu-2-intshi ezungeze inkaba yakho (inkinobho yesisu) kanye nasokhalo lwakho. Sebenzisa indawo ehlukile ngomjovo ngamunye. Ungafaki endaweni lapho isikhumba sinobuhlungu, sibomvu, silimele, sivuvukile, sishiswe yilanga, siqinile, sishisa, singenwe yigciwane, noma silimele nganoma iyiphi indlela noma ezindaweni ezinemithambo ebonakalayo, izibazi, ukuqubuka noma ukwelulwa.

Funda ngokucophelela imiyalelo yomkhiqizi yokusetshenziswa eza nomuthi. Le miyalo ichaza ukuthi ungawufaka kanjani umthamo womjovo we-alirocumab. Qiniseka ukuthi ubuza usokhemisi noma udokotela wakho uma unemibuzo mayelana nokuthi ungawujova kanjani lo muthi.

Susa isirinji efakiwe noma ipeni lokufaka elifakwe efrijini bese ulivumela lifudumale ekamelweni lokushisa cishe imizuzu engama-30 kuye kwangama-40 ngaphambi kokulisebenzisa. Ungasifaki isirinji ekhethiwe noma ipeni lokufaka elincanyelwayo emuva esiqandisini ngemuva kokufudunyezwa ekamelweni lokushisa.

Ngaphambi kokusebenzisa umjovo we-alirocumab, bheka isixazululo kusirinji noma ipeni oyikhethile eduze. Umuthi kufanele ucacele ophuzi okhanyayo futhi ungenazinhlayiya ezintantayo. Unganyakazisi isirinji ekhethiwe noma ipeni lokufaka elithanjisiwe eligcwele umjovo we-alirocumab.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokusebenzisa umjovo we-alirocumab,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-alirocumab injection, noma imuphi omunye umuthi, noma iziphi izithako zomjovo we-alirocumab. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho uma ngabe uke waba nezimo zezempilo noma wake waba nazo.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi usebenzisa umjovo we-alirocumab, shayela udokotela wakho.

Yidla ukudla okunamafutha aphansi, okunamafutha amancane. Qiniseka ukuthi ulandela zonke izincomo zokuzivocavoca nezokudla ezenziwa ngudokotela wakho noma udokotela odlayo. Ungavakashela iwebhusayithi ye-National Cholesterol Education Program (NCEP) ukuthola eminye imininingwane yokudla ku: http://www.nhlbi.nih.gov/health/public/heart/chol/chol_tlc.pdf.

Uma ujova umjovo we-alirocumab njalo emavikini ama-2, jovela umjovo we-alirocumab umjovo ngokushesha nje uma uwukhumbula uma kungakapheli izinsuku eziyi-7 zedosi elilahlekile bese uqala uhlelo lwakho lokuqala. Kodwa-ke, uma isikhathi eside kunezinsuku eziyi-7 kusuka kumthamo ongabanjwanga, weqa lo mthamo, bese ulinda kuze kufike umthamo wakho olandelayo ohleliwe njalo.

Uma ujova umjovo we-alirocumab njalo emavikini amane, jovela umjovo ongabanjwanga we-alirocumab injection ngokushesha nje uma uwukhumbula uma kungakapheli izinsuku eziyi-7 zedosi elilahlekile bese uqala uhlelo lwakho lokuqala. Uma sekude kunezinsuku eziyi-7 kusuka kumthamo ongabanjwanga, bese ujove umthamo bese uqala uhlelo olusha lwamaviki angu-4 olususelwa kulolu suku.

Musa ukujova umthamo ophindwe kabili ukwenzela umthamo ongabanjwanga. Shayela udokotela wakho uma uphuthelwa umthamo futhi unemibuzo mayelana nokuthi wenzeni.

Umjovo we-Alirocumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ububomvu, ukulunywa, ukuvuvukala, ubuhlungu, noma isisa endaweni yomjovo
• izimpawu ezinjengomkhuhlane, umkhuhlane, ikhanda elibuhlungu, amakhaza

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukusebenzisa umjovo we-alirocumab bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukulunywa
• ukuqubuka
• isifuba
• ukuphefumula kanzima noma ukugwinya
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe namehlo

Umjovo we-Alirocumab ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi usebenzisa lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Yigcine esiqandisini, kodwa ungayifaki iqhwa. Umjovo we-Alirocumab nawo ungagcinwa ekamelweni lokushisa kuze kufike ku-77 degrees F (25 degrees C) kwikhathoni lokuqala kuze kube yizinsuku ezingama-30. Ngemuva kwezinsuku ezingama-30, i-alirocumab kufanele ilahlwe kude. Gcina umjovo we-alirocumab uvikelekile ekukhanyeni kwikhathoni yoqobo.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho kumjovo we-alirocumab.

Ungavumeli omunye umuntu asebenzise imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Okubalulekile^®