IValsartan neSacubitril

-Delile

• Ngaphambi kokuthatha i-valsartan ne-sacubitril,
• IValsartan ne-sacubitril kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, shayela udokotela wakho ngokushesha:

Tshela udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Ungathathi inhlanganisela ye-valsartan ne-sacubitril uma ukhulelwe. Uma ukhulelwa ngenkathi uthatha i-valsartan ne-sacubitril, yeka ukuthatha i-valsartan ne-sacubitril bese ushayela udokotela wakho ngokushesha. Ukuhlanganiswa kwe-valsartan ne-sacubitril kungadala ukufa noma ukulimala okungathi sína embungwini lapho kuthathwe ezinyangeni eziyisithupha zokugcina zokukhulelwa.

Ukuhlanganiswa kwe-valsartan ne-sacubitril kuvame ukusetshenziselwa ukuhambisana neminye imithi yokwehlisa ingozi yokufa nokulaliswa esibhedlela kubantu abadala abanezinhlobo ezithile zokwehluleka kwenhliziyo. Inhlanganisela ye-valsartan ne-sacubitril isetshenziselwa ukwelapha izinhlobo ezithile zokwehluleka kwenhliziyo ezinganeni ezinonyaka owodwa nangaphezulu. UValsartan usesigabeni semithi ebizwa ngama-angiotensin II receptor antagonists. Isebenza ngokuvimba ukusebenza kwezinto ezithile zemvelo eziqinisa imithambo yegazi, ivumele igazi ukuba ligeleze ngokushelela nenhliziyo ikwazi ukupompa kahle. ISacubitril isekilasini lemithi ebizwa nge-neprilysin inhibitors. Isebenza ukusiza ukulawula ivolumu yegazi.

Inhlanganisela ye-valsartan ne-sacubitril iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa kabili ngosuku noma ngaphandle kokudla. Ukukusiza ukuthi ukhumbule ukuthatha inhlanganisela ye-valsartan ne-sacubitril, yithathe ngezikhathi ezifanayo nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-valsartan ne-sacubitril njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Uma wena noma ingane yakho ungakwazi ukugwinya amaphilisi, usokhemisi wakho angalungisa le mithi njengokumiswa ngomlomo (uketshezi). Shake ibhodlela lokumiswa kahle ngaphambi komthamo ngamunye.

Udokotela wakho angakuqala ngomthamo ophansi we-valsartan ne-sacubitril futhi ukhuphule kancane umthamo wakho.

Inhlanganisela ye-valsartan ne-sacubitril ilawula ukwehluleka kwenhliziyo kepha ayiyelaphi. Qhubeka uthathe i-valsartan ne-sacubitril noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-valsartan ne-sacubitril ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-valsartan ne-sacubitril,

• Tshela udokotela wakho kanye nosokhemisi uma une-allergen (ukuvuvukala kobuso bakho, izindebe, ulimi, noma umphimbo, noma ukuphefumula kanzima) ku-valsartan, amanye ama-angiotensin receptor blockers (ARB) afana ne-azilsartan (Edarbi, e-Edarbyclor), candesartan (Atacand, e-Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, e-Avalide), losartan (Cozaar, e-Hyzaar), olmesartan (Benicar, e-Azor, e-Benicar HCT, e-Tribenzor), telmisartan (Micardis, e Micardis HCT, e Twynsta); i-angiotensin-converting enzyme (ACE) inhibitors efana ne-benazepril (Lotensin, eLotrel), i-captopril, i-enalapril (i-Vasotec, ngesi-Vaseretic), i-fosinopril, i-lisinopril (e-Prinzide, e-Zestoretic), i-moexipril (Univasc, i-Uniretic) , e-Prestalia), i-quinapril (i-Accupril, nge-Accuretic, ngesi-Quinaretic), i-ramipril (i-Altace), noma i-trandolapril (i-Mavik, eTarka); sacubitril; noma imiphi eminye imithi; noma yiziphi izithako kumaphilisi e-valsartan nakuma-sacubitril. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• tshela udokotela wakho uma unesifo sikashukela (ushukela ophakeme wegazi) futhi uthatha i-aliskiren (Tekturna, Tekturna HCT). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-valsartan ne-sacubitril; uma unesifo sikashukela futhi uthatha i-aliskiren. Tshela nodokotela noma usokhemisi wakho uma uthatha i-ACE inhibitor efana ne-benazepril (Lotensin, eLotrel), i-captopril, i-enalapril (i-Vasotec, ngesi-Vaseretic), i-fosinopril, i-lisinopril (ePrinzide, eZestoretic), moexipril (Univasc, in Uniretic ), perindopril (Aceon, in Prestalia), quinapril (Accupril, in Accuretic, in Quinaretic), ramipril (Altace), noma trandolapril (Mavik, eTarka), noma uma uyekile ukuthatha i-ACE inhibitor emahoreni angama-36 adlule. Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-valsartan ne-sacubitril uma uthatha i-ACE-inhibitor.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qinisekisa ukusho okulandelayo: i-ARB efana ne-azilsartan (Edarbi, e-Edarbyclor), candesartan (Atacand, e-Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, e-Avalide), losartan (Cozaar, e-Hyzaar), olmesartan (IBenicar, e-Azor, eBenicar HCT, eTribenzor), telmisartan (Micardis, eMicardis HCT, eTwynsta); i-aspirin neminye imishanguzo yokulwa nokuvuvukala (i-NSAID) efana ne-ibuprofen (Advil, Motrin) ne-naproxen (Aleve, Naprosyn) kanye ne-COX-2 inhibitors ekhethiwe efana ne-celecoxib (Celebrex); i-diuretics ('amaphilisi amanzi'), kufaka phakathi i-potassium-sparing diuretics efana ne-amiloride (Midamor), spironolactone (Aldactone, e-Aldactazide), ne-triamterene (Dyrenium, eDyazide, eMaxzide); gemfibrozil (Lopid); eminye imithi yokwelapha umfutho wegazi ophakeme noma inkinga yenhliziyo; i-lithium (i-Lithobid); nezithako ze-potassium. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho uma ngabe uke waba ne-angioedema noma ifa (isimo esizuzwe njengefa esidala iziqephu zokuvuvukala ezandleni, ezinyaweni, ebusweni, emoyeni noma emathunjini); isifo sikashukela noma izinso, noma isifo sesibindi.
• tshela udokotela wakho uma uncelisa. Ungancelisi ibele ngenkathi uthatha i-valsartan ne-sacubutril.
• kufanele wazi ukuthi i-valsartan ne-sacubutril kungadala isizungu, ikhanda elikhanyayo, nokuquleka lapho uvuka ngokushesha okukhulu endaweni yokulala. Lokhu kuvame kakhulu lapho uqala ukuthatha i-valsartan ne-sacubitril. Ukusiza ukugwema le nkinga, phuma embhedeni kancane, uphumule izinyawo zakho phansi imizuzu embalwa ngaphambi kokuma.
• kufanele wazi ukuthi isifo sohudo, ukuhlanza, ukungaphuzi uketshezi olwanele, nokujuluka kakhulu kungadala ukwehla kwengcindezi yegazi, okungadala ikhanda elincane nokuquleka. Tshela udokotela wakho uma unanoma iyiphi yalezi zinkinga noma uzithuthukise ngesikhathi sokwelashwa kwakho.

Ungasebenzisi okokufaka usawoti okuqukethe i-potassium ngaphandle kokukhuluma nodokotela wakho. Uma udokotela wakho ekutshela ukuthi udle usawoti ophansi noma ukudla okune-sodium eningi, landela lezi zinkomba ngokucophelela.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

IValsartan ne-sacubitril kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukukhwehlela
• ukukhathala ngokweqile

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, shayela udokotela wakho ngokushesha:

• ukuqubuka
• ukulunywa
• ukuvuvukala kwezindebe, ulimi, ubuso, noma umphimbo
• ukuphefumula kanzima

Ukuhlanganiswa kwe-valsartan ne-sacubitril kungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina amaphilisi ekamelweni lokushisa kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Gcina ibhodlela lokumiswa ngomlomo ekamelweni lokushisa kuze kube yizinsuku eziyi-15; ungayifaki esiqandisini.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho anga-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-valsartan naku-sacubitril.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Entresto^®