I-Ponatinib

-Delile

• Ngaphambi kokuthatha i-ponatinib,
• I-Ponatinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, yeka ukuthatha i-ponatinib bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Ponatinib ingadala amahlule egazi abucayi noma asongela ukuphila emilenzeni yakho noma emaphashini, ekuhlaselweni yinhliziyo, noma kohlangothi. Tshela udokotela wakho uma ngabe uke waba negazi emaphashini noma emilenzeni yakho; isifo sohlangothi; umfutho wegazi ophakeme; i-hyperlipidemia (amazinga aphezulu we-cholesterol egazini lakho); ukushaya kwenhliziyo okuhamba kancane, okusheshayo, noma okungajwayelekile; isifo semithambo yegazi (ukuncipha kwemithambo yegazi ezinyaweni, emilenzeni, noma ezingalweni okubangela ukuba ndikindiki, ubuhlungu, noma ukubanda kuleyo ngxenye yomzimba); isifo senhliziyo; noma isifo senhliziyo. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ubuhlungu besifuba; ukuphelelwa umoya; isiyezi noma ukuquleka; ukudideka okungazelelwe noma inkinga yokukhuluma noma ukuqonda; ukuba ndikindiki okungazelelwe noma ukuba buthakathaka kobuso, ingalo, noma umlenze ohlangothini olulodwa lomzimba; ikhanda elibuhlungu ngokuzumayo; umlenze, ingalo, iqolo, intamo, noma ubuhlungu bomhlathi; umuzwa wokufudumala emlenzeni ongezansi; noma ukuvuvukala kwezinyawo, amaqakala, noma imilenze engezansi.

I-Ponatinib ingadala ukwehluleka kwenhliziyo okuyingozi noma okusongela impilo (isimo lapho inhliziyo ingakwazi ukupompa igazi elanele kwezinye izingxenye zomzimba) kanye ne-arrhythmias (isigqi senhliziyo esingajwayelekile). Tshela udokotela wakho uma uke waba nezinkinga zenhliziyo, kufaka phakathi ukwehluleka kwenhliziyo, ukwandiswa kwe-QT (isigqi senhliziyo esingajwayelekile esingaholela ekuphelelweni amandla, ekulahlekelweni ukwazi, ekuqulekeni noma ekufeni okungazelelwe) noma ukushaya kwenhliziyo okuhamba kancane, okusheshayo, noma okungafanele. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukuphefumula okuncane; ubuhlungu besifuba; ukushaya kwenhliziyo okusheshayo, okungajwayelekile, noma okushaya ngamandla; isiyezi; noma ukuquleka.

I-Ponatinib ingadala umonakalo omkhulu noma osongela impilo esibindini. Tshela udokotela wakho uma uke waba nesifo sesibindi noma waba nezinkinga ngesibindi sakho. Uma uhlangabezana nanoma yiziphi zalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukulunywa, amehlo aphuzi noma isikhumba, umchamo omnyama, noma ubuhlungu noma ukungahambi kahle endaweni yesisu ephezulu.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ngaphambi kokuba uqale futhi ngesikhathi sokwelashwa kwakho ukuze uhlole impendulo yomzimba wakho ku-ponatinib.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-ponatinib futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

I-Ponatinib isetshenziselwa ukwelapha izinhlobo ezithile ze-myeloid leukemia engapheli (i-CML; uhlobo lomdlavuza wamaseli amhlophe egazi), kufaka phakathi ukwelashwa kubantu abangasakwazi ukuzuza kweminye imishanguzo ye-CML noma abangakwazi ukuthatha le mithi ngenxa yemiphumela emibi. I-Ponatinib isetshenziselwa ukwelapha izinhlobo ezithile ze-acute lymphoblastic leukemia (BONKE; uhlobo lomdlavuza wamaseli amhlophe egazi) kubantu abangasakwazi ukuzuza kweminye imithi ye-leukemia noma abangakwazi ukuthatha le mithi ngenxa yemiphumela emibi. I-Ponatinib isekilasini lemithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo sephrotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunqanda ukusabalala kwamangqamuzana omdlavuza.

I-Ponatinib iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa kanye ngosuku noma ngaphandle kokudla. Thatha i-ponatinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-ponatinib njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Udokotela wakho angadinga ukubambezela ukwelashwa kwakho, ulungise umthamo wakho, noma umise unomphela ukwelashwa kwakho kwe-ponatinib ngokuya ngempendulo yakho ekwelashweni nanoma yimiphi imiphumela emibi oyitholayo. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Qhubeka uthathe i-ponatinib noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-ponatinib ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-ponatinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-ponatinib, noma imiphi eminye imishanguzo, i-lactose, noma ezinye izithako kumaphilisi e-ponatinib. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ketoconazole (Nizoral); imithi yokwehlisa i-asidi esiswini, njenge-lansoprazole (Prevacid); kanye ne-rifampin (Rifadin, Rimactane, eRifamate, eRifater). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-ponatinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho uma uke waba nenkinga yokopha noma wake waba nayo; isifo sikashukela; i-pancreatitis (ukuvuvukala kwamanyikwe, idlala ngemuva kwesisu elikhiqiza izinto ezizosiza ekugayeni); noma uma ungavumelani ne-lactose (ukungakwazi ukugaya imikhiqizo yobisi). Futhi, tshela udokotela wakho uma uphuza noma wake waphuza utshwala obuningi.
• kufanele wazi ukuthi i-ponatinib inganciphisa ukuzala kwabesifazane. Kodwa-ke, akufanele ucabange ukuthi wena noma umlingani wakho anikwazi ukukhulelwa. Tshela udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uma ungowesifazane, kuzodingeka wenze ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa. Kufanele usebenzise ukulawulwa kokubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nge-ponatinib kanye namasonto ama-3 ngemuva kokuyeka ukuthatha umuthi. Khuluma nodokotela wakho ngezinhlobo zokulawulwa kokuzalwa okuzokusebenzela. Uma ukhulelwa ngenkathi uthatha i-ponatinib, shayela udokotela wakho ngokushesha. I-Ponatinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa noma uhlela ukuncelisa. Akufanele uncelise ngenkathi uthatha i-ponatinib nezinsuku eziyisithupha ngemuva komthamo wakho wokugcina.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-ponatinib. Uma uhlelelwe ukuhlinzwa, udokotela wakho uzokutshela ukuthi uyeke ukuthatha i-ponatinib okungenani izinsuku eziyi-7 ngaphambi kokuhlinzwa noma inqubo. Udokotela wakho uzokutshela ukuthi uzoqala nini ukuthatha i-ponatinib futhi ngemuva kokuhlinzwa kwakho.
• kufanele wazi ukuthi umfutho wegazi wakho unganda ngesikhathi sokwelashwa kwakho nge-ponatinib. Udokotela wakho mhlawumbe uzoqapha ukucindezelwa kwakho kwegazi ngesikhathi sokwelashwa kwakho.

Ungadli inani elikhulu lamagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Ponatinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuqubuka
• isikhumba esomile
• isifo sohudo
• ukuqunjelwa
• ukulahleka kwezinwele
• amabala amhlophe noma izilonda ezindebeni noma emlonyeni nasemphinjeni
• ukulahlekelwa isifiso sokudla
• ukuncipha komzimba
• ukukhwehlela
• ubunzima bokulala noma ukulala
• iqolo, ithambo, ilunga, isitho noma ubuhlungu bemisipha

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, yeka ukuthatha i-ponatinib bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukulimaza noma ukopha okungavamile
• ezinegazi noma ezimnyama, izitulo zokulinda
• igazi emchameni
• ukuhlanza okunegazi
• ukopha okungavamile kwesitho sangasese sowesifazane noma okusinda kakhulu kunokujwayelekile okuya esikhathini
• hlanza okubukeka njengezizathu zekhofi
• ukuphuma kwamakhala kaningi
• ekhwehlela igazi
• amehlo omile, abomvu, abuhlungu, noma acasukile
• ukuzwela ekukhanyeni
• ukungaboni kahle, ama-float, umbono ophindwe kabili, noma ezinye izinguquko zombono
• amanxeba angapholi
• umkhuhlane, umphimbo obuhlungu, amakhaza, noma ezinye izimpawu zokutheleleka
• izinguquko ekunambithekeni; ubuthakathaka bemisipha; ukudonsa izinkophe noma ingxenye yobuso; ukuluma, ukushisa, ubuhlungu, noma ukulahlekelwa umuzwa ezandleni noma ezinyaweni
• ikhanda, ukuxhuzula, ukudideka, izinkinga zokucabanga, noma izinguquko noma ukulahleka kombono
• ukuncipha kokuchama
• ukukhathala ngokweqile noma ubuthakathaka
• ukuzuza kwesisindo
• ukuvuvukala kobuso bakho, izandla, izinyawo, amaqakala, noma imilenze engezansi
• ubuhlungu, ukuvuvukala, noma isisa esiswini (indawo yesisu)
• isicanucanu
• ukuhlanza
• ubuhlungu obuqhubekayo obuqala endaweni yesisu kepha bungasabalala baye emuva

I-Ponatinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• umkhuhlane, umphimbo obuhlungu, amakhaza nezinye izimpawu zokutheleleka
• ukushaya kwenhliziyo okusheshayo, okungajwayelekile, noma okushaya ngamandla
• ukukhathala
• ubuhlungu besifuba

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Iclusig^®