Inaliti ye-Evolocumab

-Delile

• Ngaphambi kokusebenzisa umjovo we-evolocumab,
• Umjovo we-Evolocumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukusebenzisa umjovo we-evolocumab bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Umjovo we-Evolocumab usetshenziselwa ukunciphisa ubungozi bokushaywa unhlangothi noma isifo senhliziyo noma isidingo sokuhlinzwa kwe-coronary artery bypass (CABG) kubantu abanesifo senhliziyo. Umjovo we-Evolocumab uyasetshenziswa kanye nokudla kuphela noma kuhlanganiswe neminye imishanguzo yokwehlisa i-cholesterol efana ne-HMG-CoA reductase inhibitors (ama-statins) noma i-ezetimbe (Zetia) ukwehlisa inani le-cholesterol esezingeni eliphansi ye-lipoprotein (LDL) ('cholesterol embi ') egazini, kufaka phakathi abantu abane-heterozygous hypercholesterolemia yomndeni (HeFH; isimo esizuzwe njengefa lapho i-cholesterol ingeke isuswe emzimbeni ngokujwayelekile). Ibuye isetshenziswe kanye nezinguquko zokudla nezinye izindlela zokwelapha ukunciphisa inani eliphansi le-lipoprotein (LDL) cholesterol ('cholesterol embi') egazini kubantu abane-homozygous family hypercholesterolemia (HoFH; isimo esizuzwe njengefa lapho i-cholesterol ingeke ibe khona isuswe emzimbeni ngokujwayelekile). Umjovo we-Evolocumab usesigabeni semithi ebizwa ngeproprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor monoclonal antibody. Isebenza ngokuvimba ukukhiqizwa kwe-cholesterol ye-LDL emzimbeni ukunciphisa inani le-cholesterol engakha ezindongeni zemithambo futhi ivimbele ukugeleza kwegazi liye enhliziyweni, ebuchosheni nakwezinye izingxenye zomzimba.

Ukuqoqeka kwecholesterol ezindongeni zemithambo yakho (inqubo eyaziwa njenge-atherosclerosis) kunciphisa ukugeleza kwegazi, ngakho-ke, ukunikezwa komoya-mpilo enhliziyweni yakho, ebuchosheni nakwezinye izingxenye zomzimba wakho.

Umjovo we-Evolocumab uza njengesisombululo (uketshezi) kusirinji ekhethiwe, i-autoinjector ekhethiwe, naku-infusor esemzimbeni ene-cartridge ekhethiwe ukujova ngomgogodla (ngaphansi kwesikhumba). Lapho umjovo we-evolocumab usetshenziselwa ukwelapha i-HeFH noma isifo senhliziyo nemithambo yegazi noma ukunciphisa ubungozi bokushaywa unhlangothi, isifo senhliziyo, nokuhlinzwa kwemithambo yegazi, kuvamise ukujova njalo emavikini amabili noma kanye ngenyanga. Lapho umjovo we-evolocumab usetshenziselwa ukwelapha i-HoFH, uvamise ukujova kanye ngenyanga. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Sebenzisa umjovo we-evolocumab njengoba uqondisiwe. Ungawusebenzisi kakhulu lo muthi noma uwusebenzise kaningi noma isikhathi eside kunokuyalelwa ngudokotela wakho.

Uma usebenzisa umjovo we-evolocumab kanye ngenyanga (420 mg dose), jove kanye ngaphezulu kwemizuzu engu-9 nge-infusor esemzimbeni kanye ne-cartridge ekhethiwe yomjovo ngamunye noma ujove imijovo emi-3 ehlukene ngokulandelana ngaphakathi kwemizuzu engama-30, usebenzisa okokufaka okuhlukile isipetu noma i-autoinjector efakiwe yomjovo ngamunye.

Umjovo we-Evolocumab usiza ukulawula amazinga e-cholesterol futhi wehlise ubungozi bokushaywa unhlangothi, isifo senhliziyo, noma ukuhlinzwa kwemithambo yegazi, kepha ayizelaphi lezi zimo noma iqede lezi zingozi. Qhubeka nokusebenzisa umjovo we-evolocumab noma ngabe uzizwa uphilile. Ungayeki ukusebenzisa umjovo we-evolocumab ngaphandle kokukhuluma nodokotela wakho.

Umjovo we-Evolocumab uza nge-autoinjector ekhethiwe, imijovo ekhethiwe, naku-infusor ene-cartridge ekhethiwe equkethe imishanguzo eyanele yedosi elilodwa. Hlala njalo ujova i-evolocumab ku-autoinjector yayo ethandwayo, isirinji, noma i-infusor nge-cartridge ekhethiwe; ungalinge uyixube nomunye umuthi. Lahla izinaliti, imijovo, namadivayisi esitsheni esingamelana nokubhoboza. Khuluma nodokotela wakho noma usokhemisi mayelana nokuthi ungasilahla kanjani isitsha esingamelana nokubhoboza.

Ungafaka umjovo we-evolocumab ngaphansi kwesikhumba emathangeni akho noma endaweni yesisu, ngaphandle kwendawo engu-2-intshi ezungeze inkaba yakho (inkinobho yesisu). Uma omunye umuntu ezokujolela umuthi, lowo muntu angawufaka engalweni yakho engenhla. Sebenzisa indawo ehlukile ngomjovo ngamunye. Ungafaki umjovo we-evolocumab endaweni ethambile, elimele, ebomvu noma eqinile. Futhi, musa ukujova ezindaweni ezinezibazi noma izimpawu zokwelula.

Funda ngokucophelela imiyalelo yomkhiqizi yokusetshenziswa eza nomuthi. Le miyalo ichaza ukuthi ungawujova kanjani umthamo womjovo we-evolocumab. Qiniseka ukuthi ubuza usokhemisi noma udokotela wakho ukuthi wena noma umuntu ozojova unemibuzo mayelana nokuthi ungawujova kanjani lo muthi. Bheka Imiyalo yokusetshenziswa kusuka kumkhiqizi ku-https: //bit.ly/3jTG7cx.

Susa isirinji efakiwe noma i-autoinjector efakwe efrijini bese uyivumela ukuba ifudumale ekamelweni lokushisa imizuzu engama-30 ngaphambi kokuyisebenzisa. Susa i-infusor nge-cartridge ekhethiwe kusuka esiqandisini bese uyivumela ukuthi ifudumale ekamelweni lokushisa imizuzu engu-45 ngaphambi kokuyisebenzisa. Ungafaki umjovo we-evolocumab emanzini ashisayo, i-microwave, noma uyibeke elangeni.

Ngaphambi kokusebenzisa umjovo we-evolocumab, bheka isixazululo eduze. Umuthi kufanele ucacele ophuzi okhanyayo futhi ungenazinhlayiya ezintantayo. Unganyakazisi isirinji ekhethiwe, i-autoinjector efakiwe, noma i-infusor ngegobolondo eligcwalisiwe eliqukethe umjovo we-evolocumab.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokusebenzisa umjovo we-evolocumab,

• Tshela udokotela wakho kanye nosokhemisi uma une-aleji kumjovo we-evolocumab, noma imiphi eminye imishanguzo, i-latex, i-raber, noma ezinye izithako zomjovo we-evolocumab. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho uma ngabe uke waba nezimo zezempilo noma wake waba nazo.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi usebenzisa umjovo we-evolocumab, shayela udokotela wakho.

Yidla ukudla okunamafutha aphansi, okunamafutha amancane. Qiniseka ukuthi ulandela zonke izincomo zokuzivocavoca nezokudla ezenziwa ngudokotela wakho noma udokotela odlayo. Ungavakashela iwebhusayithi ye-National Cholesterol Education Program (NCEP) ukuthola eminye imininingwane yokudla ku: http://www.nhlbi.nih.gov/health/public/heart/chol/chol_tlc.pdf.

Uma ufaka umjovo we-evolocumab njalo emavikini ama-2 futhi uma kungakapheli izinsuku eziyi-7 kusuka kumthamo wakho olahlekile, wufake ngomjovo ngokushesha uma usukhumbula bese uqhubeka nesimiso sakho sokulinganisa. Kodwa-ke, uma kunezinsuku ezingaphezu kwezingu-7 kusuka kumthamo wakho olahlekile, weqe bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Musa ukujova umthamo ophindwe kabili ukwenzela umthamo ongabanjwanga. Shayela udokotela wakho uma uphuthelwa umthamo futhi unemibuzo mayelana nokuthi wenzeni.

Uma ujova umjovo we-evolocumab kanye ngenyanga futhi uma kungakapheli izinsuku eziyi-7 kusuka kumthamo wakho ogejuliwe, yijove ngokushesha nje lapho uyikhumbula bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Kodwa-ke, uma ufaka umjovo we-evolocumab kanye ngenyanga futhi kunezinsuku ezingaphezu kwezingu-7 kusuka kumthamo wakho olahlekile, wufake ngokushesha bese uqala uhlelo olusha lokulinganisa ngokusekelwe kulolu suku. Musa ukujova umthamo ophindwe kabili ukwenzela umthamo ongabanjwanga. Shayela udokotela wakho uma uphuthelwa umthamo futhi unemibuzo mayelana nokuthi wenzeni.

Umjovo we-Evolocumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ububomvu, ukulunywa, ukuvuvukala, ubuhlungu, noma isisa endaweni yomjovo
• izimpawu ezinjengomkhuhlane, ikhala eligobayo, umphimbo obuhlungu, umkhuhlane, noma ukugodola
• ubuhlungu noma ukushisa ngesikhathi uchama
• ubuhlungu bemisipha noma beqolo
• isiyezi
• ubuhlungu besisu

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukusebenzisa umjovo we-evolocumab bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukulunywa
• ukuqubuka
• isifuba
• ukuphefumula kanzima noma ukugwinya
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe namehlo

Umjovo we-Evolocumab ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi usebenzisa lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Yigcine esiqandisini, kodwa ungayifaki iqhwa. Ungashiyi umjovo we-evolocumab ngaphandle kwesiqandisi izinsuku ezingaphezu kwezingu-30. Umjovo we-Evolocumab ungagcinwa ekamelweni lokushisa lekhathuni lokuqala kuze kube yizinsuku ezingama-30. Gcina umjovo we-evolocumab kude nokukhanya okuqondile.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho kumjovo we-evolocumab.

Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nomjovo we-evolocumab.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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