Inaliti yeTrabectedin

-Delile

• Ngaphambi kokuthola umjovo we-trabectedin,
• Umjovo weTrabectedin ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

Umjovo we-Trabectedin usetshenziselwa ukwelapha i-liposarcoma (umdlavuza oqala kumaseli anamafutha) noma i-leiomyosarcoma (umdlavuza oqala ngezicubu zemisipha ebushelelezi) osabalele kwezinye izingxenye zomzimba futhi awukwazi ukwelashwa ngokuhlinzwa kubantu asebevele belashwa ngemithi ethile yamakhemikhali. I-Trabectedin isekilasini lemithi ebizwa ngama-alkylating agents. Isebenza ngokunciphisa noma ukumisa ukukhula kwamangqamuzana omdlavuza emzimbeni wakho.

Umjovo weTrabectedin uza njengempuphu ezohlanganiswa noketshezi oluzofakwa ngaphezu kwamahora angama-24 ngemithambo (emthanjeni) ngudokotela noma umhlengikazi esikhungweni sezokwelapha. Imvamisa unikezwa kanye njalo emavikini ama-3 inqobo nje uma udokotela wakho encoma ukuthi uthole ukwelashwa.

Udokotela wakho angabambezela noma ayeke ukwelashwa kwakho ngomjovo we-trabectedin ngokuya ngempendulo yakho emithini kanye neminye imiphumela emibi ohlangabezana nayo. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho.

Udokotela wakho mhlawumbe uzokunikeza umuthi okufanele uwuthathe ngaphambi kokuthola umthamo ngamunye we-trabectedin ukusiza ukuvimbela imiphumela emibi.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-trabectedin,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-trabectedin injection, noma imuphi omunye umuthi, noma iziphi izithako zomjovo we-trabectedin. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ama-antifungal athile afana ne-itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), ne-voriconazole (Vfend); i-boceprevir (i-Victrelis); i-clarithromycin (i-Biaxin, ku-Prevpac); i-conivaptan (iVaprisol); imishanguzo ethile ye-HIV okubandakanya i-indinavir (Crixivan), lopinavir (eKaletra), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra, Technivie, others), kanye ne-saquinavir (Invirase); nefazodone; i-phenobarbital; i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); i-telaprevir (Incivek; ayisatholakali e-U.S.); kanye ne-telithromycin (Ketek). Udokotela wakho angadinga ukushintsha imithamo noma isikhathi semithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingase futhi ihlanganyele ne-trabectedin, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• utshele udokotela wakho uma uke waba nesifo sesibindi noma sezinso.
• kufanele wazi ukuthi umjovo we-trabectedin ungadala ukungabi nenzalo (ubunzima bokukhulelwa); noma kunjalo, akufanele ucabange ukuthi awukwazi ukukhulelwa. Tshela udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uma ungowesifazane, kufanele usebenzise ukulawulwa kokubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nge-trabectedin futhi okungenani izinyanga ezimbili ngemuva kokuyeka ukusebenzisa umuthi. Uma ungowesilisa, wena nomlingani wakho wesifazane kufanele nisebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa nge-trabectedin futhi niqhubeke izinyanga ezinhlanu ngemuva kokuyeka ukuthola umjovo we-trabectedin. Uma ukhulelwa ngenkathi usebenzisa umjovo we-trabectedin, shayela udokotela wakho. Umjovo we-Trabectedin ungalimaza umbungu futhi wandise ingozi yokulahleka kokukhulelwa.
• tshela udokotela wakho uma uncelisa. Ungancelisi ibele ngenkathi uthola umjovo we-trabectedin.

Ungadli i-grapefruit noma uphuze ijusi lamagilebhisi ngenkathi uthola lo muthi.

Umjovo weTrabectedin ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukukhathala
• ikhanda
• ubuhlungu obuhlangene
• ukuqunjelwa
• isifo sohudo
• ukuncipha kokudla
• ubunzima bokulala noma ukulala

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• ububomvu, ukuvuvukala, ukulunywa nokungaphatheki kahle noma ukuvuza endaweni yokujova
• ukuvuvukala kobuso
• ukuphefumula kanzima
• ukuqina kwesifuba
• isifuba
• ukuqubuka
• isiyezi esinzima noma ikhanda elikhanyayo
• imfiva
• ukulimaza noma ukopha okungavamile
• ukuphaphatheka
• ukuphuzi kwesikhumba namehlo
• ubuhlungu endaweni ephezulu yesisu
• isicanucanu
• ukuhlanza
• ubunzima bokugxila
• ukudideka
• ubuhlungu besifuba
• ukuphelelwa umoya
• ukuvuvukala kwemilenze yakho, amaqakala, noma izinyawo
• ubuhlungu bemisipha noma ubuthakathaka

Umjovo we-Trabectedin ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-trabectedin.

Buza usokhemisi wakho noma imiphi imibuzo onayo ngomjovo we-trabectedin.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Yondelis^®