Inaliti yeTalimogene Laherparepvec

-Delile

• Ngaphambi kokuthola umjovo we-talimogene laherparepvec,
• Umjovo weTalimogene laherparepvec ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, shayela udokotela wakho ngokushesha:

Umjovo weTalimogene laherparepvec usetshenziselwa ukwelapha isimila esithile se-melanoma (uhlobo lomdlavuza wesikhumba) esingasuswa ngokuhlinzwa noma esibuya ngemuva kokuphathwa ngokuhlinzwa. I-Talimogene laherparepvec isekilasini lemithi ebizwa ngama-oncolytic virus. Kuyindlela ebuthakathaka futhi eshintshiwe yeHerpes Simplex Virus Type I (HSV-1 ’cold virus virus’) esebenza ngokusiza ukubulala amangqamuzana omdlavuza.

Umjovo weTalimogene laherparepvec uza njengokumiswa (uketshezi) ukujova udokotela noma umhlengikazi ehhovisi lezokwelapha. Udokotela wakho uzofaka umuthi ngqo kumathumba asesikhumbeni sakho, ngaphansi kwesikhumba sakho, noma kuma-lymph node akho. Uzothola ukwelashwa kwesibili ngemuva kwamasonto amathathu ukwelashwa kokuqala, bese kuthi njalo emva kwamasonto ama-2 ngemuva kwalokho. Ubude bokwelashwa buxhomeke ekutheni izicubu zakho zisabela kanjani ekwelashweni. Udokotela wakho kungenzeka angajovi wonke amathumba ekuvakasheni ngakunye.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-talimogene laherparepvec futhi isikhathi ngasinye lapho uthola imijovo. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-talimogene laherparepvec,

• Tshela udokotela kanye nosokhemisi wakho uma une-aleji ye-talimogene laherparepvec, noma imiphi eminye imithi, noma yiziphi izithako zomjovo we-talimogene laherparepvec. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma uthatha noma yimiphi imithi eyenza amasosha akho omzimba abe buthakathaka njenge-antithymocyte globulin (Atgam, Thymoglobulin), azathioprine (Azasan, Imuran), basiliximab (Simulect), belatacept (Nulojix), belimumab (Benlysta), cortisone, cyclosporine ( Gengraf, Neoral, Sandimmune), dexamethasone, fludrocortisone, methotrexate (Otrexup, Rasuvo, Trexall), methylprednisolone (Depo-medrol, Medrol, Solu-medrol), mycophenolate mofetil (Cellcept), prednisolone (Flopred, Orapred, Pediapred, Pediapred URayos), i-sirolimus (i-Rapamune), ne-tacrolimus (i-Astagraf XL, i-Prograf, i-Envarsus XR). Eminye imithi eminingi inganciphisa amasosha akho omzimba, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu. Udokotela wakho mhlawumbe uzokutshela ukuthi ungatholi i-talimogene laherparepvec uma uthatha eyodwa noma ngaphezulu yale mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: noma imiphi imishanguzo yokulwa namagciwane efana ne-acyclovir (Sitavig, Zovirax), cidofovir, docosanol (Abreva), famciclovir (Famvir), foscarnet (Foscavir), ganciclovir (Cytovene), penciclovir (Denavir) (trifluridine) I-Viroptic), i-valacyclovir (i-Valtrex), ne-valganciclovir (i-Valcyte). Le mithi ingathinta ukuthi isebenza kanjani kahle i-talimogene laherparepvec.
• Tshela udokotela wakho uma uke waba ne-leukemia (umdlavuza wamangqamuzana amhlophe egazi), i-lymphoma (umdlavuza wengxenye yesistimu yomzimba), igciwane lesandulela ngculazi (i-HIV), i-immunodeficiency syndrome (i-AIDS), noma esinye isimo lokho kudala amasosha omzimba abe buthakathaka. Udokotela wakho cishe ngeke afune ukuthi ungatholi umjovo we-talimogene laherparepvec.
• Tshela udokotela wakho ukuthi uke waphathwa ngemisebe endaweni yezicubu ze-melanoma, i-myeloma eminingi (umdlavuza wamaseli e-plasma emnkantsheni wethambo), noma yiluphi uhlobo lwesifo sokuzivikela komzimba (izimo lapho amasosha omzimba ehlasela khona izingxenye ezinempilo umzimba futhi kubangele ubuhlungu, ukuvuvukala, nokulimala), noma uma usondelana kakhulu nomuntu okhulelwe noma onamasosha omzimba antekenteke.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Akufanele ukhulelwe ngesikhathi sokwelashwa kwakho ngomjovo we-talimogene laherparepvec. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma ukhulelwa ngenkathi uthola umjovo we-talimogene laherparepvec, shayela udokotela wakho ngokushesha. Umjovo weTalimogene laherparepvec ungalimaza umbungu.
• kufanele wazi ukuthi umjovo we-talimogene laherparepvec uqukethe igciwane elingasabalala futhi lithelele abanye abantu. Kufanele uqaphele ukumboza zonke iziza zomjovo ngamabhandeshi angangeni manzi nangamanzi okungenani isonto elilodwa ngemuva kokwelapha ngakunye, noma isikhathi eside uma ngabe indawo yokujova isiphumile. Uma amabhandeshi ekhululeka noma ewa, qiniseka ukuthi uwafaka ngokushesha. Kufanele usebenzise amagilavu ​​wenjoloba noma we-latex lapho ubopha amabhande amasayithi wokujova. Kufanele uqiniseke ukuthi ufaka yonke impahla yokuhlanza, amagilavu, namabhandeshi asetshenziselwe izindawo zokujova esikhwameni sepulasitiki esivaliwe bese uzilahla kudoti.
• akufanele uthinte noma uklwebheke izindawo zokujova noma amabhandeshi. Lokhu kungasabalalisa igciwane emithini ye-talimogene laherparepvec kwezinye izingxenye zomzimba wakho. Abantu abakuzungezile kufanele baqaphele ukuthi bangahlangani ngqo nezindawo zakho zokujova, amabhandeshi, noma uketshezi lomzimba. Shayela udokotela wakho ngokushesha uma wena, noma omunye umuntu okuzungezile, eba nezimpawu zokutheleleka nge-herpes ;: ubuhlungu, ukuvutha, noma ukubhoboza i-blister ngomlomo wakho, isitho sangasese, iminwe, noma izindlebe; ubuhlungu beso, ubomvu, noma ukudwengula; ukungaboni kahle; ukuzwela ekukhanyeni; ubuthakathaka ezingalweni noma emilenzeni; ukozela ngokweqile; noma ukudideka kwengqondo.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Umjovo weTalimogene laherparepvec ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukukhathala okungavamile
• isicanucanu
• ukuhlanza
• isifo sohudo
• ukuqunjelwa
• ubuhlungu besisu
• ikhanda
• isiyezi
• ukuncipha komzimba
• isikhumba esomile, esiqhekekile, esilumayo, esivuthayo
• ubuhlungu bemisipha noma bamalunga
• ubuhlungu ezingalweni noma emilenzeni
• ukuphulukiswa okwenziwe kancane kwezindawo zokujova
• ubuhlungu ezindaweni zokujova

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, shayela udokotela wakho ngokushesha:

• ukuphelelwa umoya noma ezinye izinkinga zokuphefumula
• ukukhwehlela
• i-pink, i-cola enemibala, noma umchamo wamagwebu
• ukuvuvukala kobuso, izandla, izinyawo, noma isisu
• ukulahlekelwa umbala esikhumbeni sakho, izinwele noma amehlo
• isikhumba esifudumele, esibomvu, esivuvukile, noma esibuhlungu esizungeze indawo yomjovo
• umkhuhlane, umphimbo obuhlungu, amakhaza, noma ezinye izimpawu zokutheleleka
• izicubu ezifile noma izilonda ezivulekile kumathumba afakiwe

Umjovo weTalimogene laherparepvec ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho.

Buza usokhemisi wakho noma imiphi imibuzo onayo ngomjovo we-talimogene laherparepvec.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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