I-Obeticholic Acid

-Delile

• Ngaphambi kokuthatha i-obeticholic acid,
• I-Obeticholic acid ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Obeticholic acid ingadala ukulimala kwesibindi okungathi sína noma okusongela ukuphila, ikakhulukazi uma umthamo we-obeticholic acid ungalungiswa lapho isifo sesibindi siba sibi. Uma uhlangabezana nalezi zimpawu ezilandelayo ngenkathi uthatha i-obeticholic acid, shayela udokotela wakho ngokushesha: ukuphuzi kwesikhumba noma kwamehlo, umchamo omnyama, indle emnyama yokulinda, ukukhwehlela noma ukugabha igazi, isicanucanu, ukuhlanza, ubuhlungu besisu, ukuvuvukala ngaphakathi nangaseduzane indawo yesisu, ukwehla kwesisindo, ukungathandi ukudla, ukukhathala, isifo sohudo, ukudideka, ukukhuluma okungaqondakali, ukukhathazeka, ukuguquguquka kwemizwelo, izinguquko ebuntwini, noma ukuchama kaningi.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho angalawula izivivinyo ezithile ngaphambi nangesikhathi sokwelashwa kwakho ukuze uhlole ukusebenza kwesibindi sakho kanye nempendulo yomzimba wakho ku-obeticholic acid.

I-Obeticholic acid isetshenziswa yodwa noma ihlanganiswe ne-ursodiol (i-Actigall, i-Urso) ukwelapha i-cholangitis eyinhloko ye-biliary (PBC; uhlobo lwesifo sesibindi esonakalisa imithambo yenyongo, evumela i-bile ukuthi ihlale esibindini bese idala umonakalo) kubantu abangakwazi ukuthatha i-ursodiol noma kubantu abangazange baphathwe ngempumelelo nge-ursodiol kuphela. I-Obeticholic acid isekilasini lemithi ebizwa ngama-farnesoid X receptor agonists. Isebenza ngokunciphisa ukukhiqizwa kwenyongo esibindini nokwandisa ukususwa kwenyongo esibindini.

I-Obeticholic acid iza njengethebhulethi ezothathwa ngomlomo. Kuthathwa ngokujwayelekile kanye ngosuku noma ngaphandle kokudla. Thatha i-obeticholic acid ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-obeticholic acid njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Udokotela wakho kungadingeka ukuthi ayeke ukwelashwa kwakho okwesikhashana noma unomphela noma anciphise umthamo wakho we-obeticholic acid ngesikhathi sokwelashwa kwakho. Lokhu kuzoya ngokuthi umuthi usebenza kanjani kuwe noma uma uhlangabezana nemiphumela ethile emibi. Qhubeka uthathe i-obeticholic acid noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-obeticholic acid ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-obeticholic acid,

• Tshela udokotela kanye nosokhemisi wakho uma uxabana ne-obeticholic acid, noma imiphi eminye imithi, noma iziphi izithako ezibhebheni ze-obeticholic acid. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: i-caffeine (etholakala emithini ethile yokwelapha ukozela nekhanda), i-theophylline (i-Elixophyllin, i-Theo-24, i-Theochron, abanye), i-tizanidine (i-Zanaflex), noma i-warfarin (i-Coumadin, i-Jantoven). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-obeticholic acid, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• uma uthatha i-cholestyramine (Prevalite), i-colestipol (i-Colestid), noma i-colesevelam (i-Welchol), thatha okungenani amahora amane ngaphambi noma amahora amane ngemuva kwe-obeticholic acid.
• Tshela udokotela wakho uma unenkinga yokuvinjelwa kwe-bile (ukuvinjelwa kwamashubhu athwala inyongo kusuka esibindini kuya enyongweni nasemathunjini amancane). Udokotela wakho angakutshela ukuthi ungathathi i-obeticholic acid.
• utshele udokotela wakho uma ngabe uke waba ne-cholesterol ephezulu noma isifo se-thyroid.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-obeticholic acid, shayela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Obeticholic acid ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ubuhlungu bomlomo noma bomphimbo
• ukushaya kwenhliziyo okusheshayo, okungajwayelekile, noma okushaya ngamandla
• ukuqubuka
• isiyezi
• ukuquleka
• ukuvuvukala kwezandla, izinyawo, amaqakala, noma imilenze engezansi
• ukukhathala noma ubuthakathaka
• ubuhlungu obuhlangene noma besisipha
• ukuqunjelwa

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• ukulunywa okukhulu
• umkhuhlane, ukubanda, noma ezinye izimpawu zokutheleleka
• ukoma, ukucasuka, ububomvu, ukuqhekeka noma ukudonsa kwesikhumba

I-Obeticholic acid ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ukuphuzi kwesikhumba noma kwamehlo
• umchamo onombala omnyama
• ukulahlekelwa isifiso sokudla
• ubuhlungu engxenyeni engenhla kwesokudla yesisu
• isicanucanu
• ukuhlanza
• ukuvuvukala endaweni ezungeze isisu

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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