Inaliti ye-Atezolizumab

-Delile

• Kusetshenziswa umjovo we-Atezolizumab:
• Ngaphambi kokuthola umjovo we-atezolizumab,
• Umjovo we-Atezolizumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Kusetshenziswa umjovo we-Atezolizumab:

• ukwelapha izinhlobo ezithile zomdlavuza we-urothelial (umdlavuza wolwelwesi lwesinye nezinye izingxenye zomgudu womchamo) osakazeke noma ongasuswa ngokuhlinzwa kubantu abangakwazi ukuthola i-chemotherapy equkethe i-platinum (carboplatin, cisplatin),
• yedwa noma ngeminye imithi yokwelashwa ngamakhemikhali njengokwelashwa kokuqala kwezinhlobo ezithile zomdlavuza wamaphaphu weseli (non-small cell) (NSCLC) osabalalele kwezinye izingxenye zomzimba,
• ukwelapha uhlobo oluthile lwe-NSCLC olusabalalele kwezinye izingxenye zomzimba futhi oluye lwakhula ngesikhathi nangemva kokwelashwa ngeminye imishanguzo ye-chemotherapy,
• kanye neminye imithi yokwelashwa ngamakhemikhali njengokwelashwa kokuqala kohlobo oluthile lomdlavuza omncane wamaphaphu wamangqamuzana (i-SCLC) osakazeke kulo lonke iphaphu noma kwezinye izingxenye zomzimba,
• kanye neminye imithi yokwelashwa ngamakhemikhali njengokwelashwa kohlobo oluthile lomdlavuza webele oselusabalele kwezinye izingxenye zomzimba noma olungasuswa ngokuhlinzwa,
• ngokuhlanganiswa ne-bevacizumab (Avastin) ukwelapha i-hepatocellular carcinoma (HCC) esakaze noma ingasuswa ngokuhlinzwa kubantu abangakaze bathole i-chemotherapy ngaphambili, futhi
• ngokuhlanganiswa ne-cobimetinib (Cotellic) ne-vemurafenib (i-Zelboraf) ukwelapha izinhlobo ezithile ze-melanoma (uhlobo lomdlavuza wesikhumba) olusakazeke noma olungasuswa ngokuhlinzwa.

Umjovo we-Atezolizumab usesigabeni semithi ebizwa ngama-antibody monoclonal. Isebenza ngokuvimba ukusebenza kweprotheni ethile kumaseli womdlavuza. Lokhu kusiza amasosha omzimba omuntu ukulwa namaseli omdlavuza, futhi kusiza ukwehlisa ukukhula kwesimila.

Umjovo we-Atezolizumab uza njengoketshezi oluzofakwa emthanjeni ngaphezu kwemizuzu engama-30 kuye kwangama-60 ngudokotela noma umhlengikazi esibhedlela noma esikhungweni sezokwelapha. Lapho umjovo we-atezolizumab usetshenziselwa ukwelapha umdlavuza we-urothelial, i-NSCLC, i-SCLC, noma i-hepatocellular carcinoma, uvamise ukujova kanye njalo emavikini ama-2, 3, noma ama-4 kuye ngomthamo wakho inqobo nje uma udokotela wakho encoma ukuthi uthole ukwelashwa. Lapho umjovo we-atezolizumab usetshenziselwa ukwelapha umdlavuza webele uvame ukujova ngezinsuku 1 no-15 njengengxenye yomjikelezo wezinsuku ezingama-28. Lapho umjovo we-atezolizumab usetshenziselwa ukwelapha i-melanoma, uvamise ukujova njalo emavikini amabili. Ubude bokwelashwa kwakho buncike ekutheni umzimba wakho uphendula kahle kanjani emithini nasemiphumeleni oyitholayo.

Umjovo we-Atezolizumab ungadala ukusabela okukhulu ngesikhathi sokufakwa komuthi. Udokotela noma umhlengikazi uzokuqapha ngokucophelela ngenkathi uthola umuthi. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, tshela udokotela wakho ngokushesha: ukushaywa, ukushisa komzimba, ukugodola, ukuqhaqhazela, isiyezi, ukuzizwa uphelelwa amandla, ukuphefumula kanzima, ukuphefumula kanzima, ukulunywa, ukuqubuka, izinhlungu emuva noma entanyeni, noma ukuvuvukala kobuso noma izindebe .

Udokotela wakho kungadingeka ukuthi anciphise ukumnika kwakho, akubambezele noma ayeke ukwelashwa kwakho, noma akuphathe ngeminye imishanguzo uma uhlangabezana nemiphumela ethile emibi. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho ngomjovo we-atezolizumab.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa ngomjovo we-atezolizumab futhi isikhathi ngasinye lapho uthola umuthi. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-atezolizumab,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-atezolizumab, noma imiphi eminye imithi, noma yiziphi izithako zomjovo we-atezolizumab. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• tshela udokotela wakho uma welashelwa ukutheleleka okuthile. Phinda utshele udokotela wakho uma uke wafakelwa isitho somzimba; izinkinga zamaphaphu noma zokuphefumula; isifo esithinta isistimu yakho yezinzwa efana ne-myasthenia gravis (ukuphazamiseka kwesistimu yezinzwa okubangela ukuba buthakathaka kwemisipha) noma isifo i-Guillain-Barre syndrome (ubuthakathaka, ukuncinza, nokukhubazeka okungenzeka ngenxa yokulimala okungazelelwe kwezinzwa); isifo se-autoimmune (isimo lapho amasosha omzimba ehlasela ingxenye enempilo yomzimba) njengesifo sikaCrohn (isimo lapho amasosha omzimba ehlasela ulwelwesi lwendlela yokugaya edala ubuhlungu, isifo sohudo, ukwehla kwesisindo nomkhuhlane), ulcerative colitis ( isimo esidala ukuvuvukala nezilonda emgqeni wekholoni [amathumbu amakhulu] ne-rectum) noma i-lupus (isimo lapho amasosha omzimba ahlasela khona izicubu nezitho eziningi kubandakanya isikhumba, amalunga, igazi, nezinso); noma isifo sesibindi.
• utshele udokotela wakho uma ukhulelwe, noma uhlele ukukhulelwa. Akufanele ukhulelwe ngesikhathi sokwelashwa kwakho nezinyanga ezi-5 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma ukhulelwa ngenkathi uthola umjovo we-atezolizumab, shayela udokotela wakho ngokushesha.
• tshela udokotela wakho uma uncelisa. Udokotela wakho uzokutshela ukuthi ungancelisi ngesikhathi sokwelashwa kwakho nezinyanga ezi-5 ngemuva komthamo wakho wokugcina.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Umjovo we-Atezolizumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• iqolo, intamo, noma ubuhlungu bamalunga
• ukuqubuka
• ukulunywa
• unenkinga yokulala noma ukuhlala ulele
• ukukhathala ngokweqile
• isikhumba esiphaphathekile
• ngizwe kubanda
• ukuvuvukala kwezingalo
• ukulahlekelwa isifiso sokudla
• isicanucanu
• ukuhlanza
• isifo sohudo
• ukuqunjelwa
• ukulahleka kwezinwele
• ukujula kwezwi noma ukushaqeka
• ukuzuza kwesisindo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• uhudo, ubuhlungu besisu, igazi noma amafinyila esitobhini, noma ukubambezeleka okumnyama, okunamathelayo, indle
• ubuhlungu obuqhubekayo obuqala ngaphezulu kwesobunxele noma maphakathi nesisu kepha bungadlulela emuva, umkhuhlane, isicanucanu, ukuhlanza
• ukuqunjelwa ngesisu noma ukuvuvukala
• umkhuhlane, umphimbo obuhlungu, ukukhwehlela, ukubanda, izimpawu ezinjengomkhuhlane, ukuchama kaningi, okuphuthumayo, okunzima, noma okubuhlungu, noma ezinye izimpawu zokutheleleka
• umchamo obomvana, obomvu, noma onsundu
• ukuncipha kokuchama, ukuvuvukala emilenzeni yakho, emaqakaleni noma ezinyaweni
• umlenze ofudumele, obomvu, ovuvukile noma othambile
• ukukhwehlela okusha noma okuba kubi okungaba yigazi, ukuphefumula okuncane, noma ubuhlungu besifuba
• ukuphuzi kwesikhumba noma kwamehlo, ukukhathala ngokweqile, ukopha noma ukulimaza kalula, isicanucanu noma ukuhlanza, ubuhlungu besisu, umchamo onombala omnyama, ukuncipha kwesifiso
• ikhanda elingapheli noma ikhanda elingajwayelekile, ukoma okwandayo noma ukuchama, ukushintsha kombono, ukwehla kokushayela ucansi
• ukushaya kwenhliziyo okusheshayo, ukwanda kwesifiso sokudla, ukunciphisa umzimba ngokungazelelwe, ukuzwa ukushisa, ukuguquka kwemizwelo
• ubuthakathaka bemisipha, ukuba ndikindiki noma ukuncinza ezandleni zakho, ezinyaweni, ezingalweni, noma emilenzeni, umkhuhlane, ukudideka, ukuguquka kwemizwelo noma isimilo, ukuzwela ekukhanyeni, ukuqina kwentamo
• ukufiphala noma ukubona kabili, noma ezinye izinkinga zombono, ubuhlungu bamehlo noma ubomvu
• isiyezi noma ukuzwa ukuquleka
• uzizwe ulambile kakhulu noma womile kunokujwayelekile, ukwanda kokuchama, ukukhathala ngokweqile, ubuthakathaka, ukuphefumula okunuka izithelo
• ushintsho esimweni sokuziphatha noma ekuziphatheni (ukwehla kokushayela ucansi, ukucasuka, ukudideka, noma ukukhohlwa)
• ubuhlungu besifuba, ukuqabuleka komoya, ukushaya kwenhliziyo okungajwayelekile, ukuvuvukala kwamaqakala, ukungakwazi ukuzivocavoca ngendlela owawenza ngayo

Umjovo we-Atezolizumab ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zebhu ngaphambi nangesikhathi sokwelashwa kwakho ngomjovo we-atezolizumab ukuhlola impendulo yomzimba wakho emithini. Kwezinye izimo, udokotela wakho uzokuyalela ukuhlolwa kwelebhu ngaphambi kokuba uqale ukwelashwa kwakho ukuze ubone ukuthi umdlavuza wakho ungelashwa nge-atezolizumab.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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