UBrigatinib

-Delile

• Ngaphambi kokuthatha i-brigatinib,
• I-Brigatinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Brigatinib isetshenziselwa ukwelapha uhlobo oluthile lomdlavuza wamaphaphu weseli (non-small cell lung cancer) (NSCLC) oselusabalele nakwezinye izingxenye zomzimba. UBrigatinib usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo sephrotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunciphisa noma ukumisa ukusabalala kwamangqamuzana omdlavuza.

UBrigatinib uza njengethebhulethi azoyithatha ngomlomo. Imvamisa kuthathwa noma ngaphandle kokudla kanye ngosuku. Thatha i-brigatinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-brigatinib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlafune noma uwachoboze.

Uma uhlanza ngemuva kokuthatha i-brigatinib, ungathathi omunye umthamo. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Udokotela wakho angakuqala ngomthamo ophansi we-brigatinib futhi akhuphule umthamo wakho kanye ngemuva kwezinsuku eziyi-7 zokwelashwa.

Udokotela wakho kungadingeka ukuthi ayeke ukwelashwa kwakho okwesikhashana noma unomphela noma anciphise umthamo wakho we-brigatinib noma eminye imishanguzo oyiphuzayo, kuya ngemiphumela oyitholayo ngenkathi welashwa. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Ungayeki ukuthatha i-brigatinib ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-brigatinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-brigatinib, noma imiphi eminye imithi, noma iziphi izithako ezikumaphilisi e-brigatinib. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ama-antifungal anjenge-itraconazole (Onmel, Sporanox, Tolsura), ketoconazole, buprenorphine ne-naloxone (Suboxone), carbamazepine (Equetro, Tegretol, Teril, others), clarithromycin, cyclosporine (Gengraf, Neoral ), diltiazem (Cardizem, Cartia, Diltzac, others), efavirenz (Sustiva, e-Atripla, Symfi), erythromycin (EES, Eryc, Erythrocin), indinavir (Crixivan), nefazodone, nelfinavir (Viracept), nevirapine (Virireptine) ; phenytoin (Dilantin, Phenytek), pioglitazone (Actos, in Actoplus Met, Duetact, Oseni), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, in Rifamate, in Rifater), ritonavir (Norvir, in Kaletra, Technivie, sirolimus (Rapamune), tacrolimus (Astagraf, Envarsus, Prograf), noma verapamil (Calan, Verelan, in Tarka). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingase futhi ihlanganyele ne-brigatinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• utshele udokotela wakho uma uke waba nomfutho wegazi ophakeme noma wake waba nawo; ukushaya kwenhliziyo okuhamba kancane; isifo sikashukela noma ezinye izinkinga zikashukela egazini; noma isifo sezinso noma sesibindi.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uhlele ukuba nobaba wengane. I-Brigatinib ingaphazamisa ukusebenza kwezindlela zokuvimbela inzalo zamahomoni (amaphilisi okulawula ukubeletha, amabala, izindandatho, okufakelwayo noma imijovo), ngakho-ke akufanele usebenzise lokhu njengendlela yakho kuphela yokulawula ukubeletha ngenkathi welashwa. Kufanele usebenzise ukulawulwa kokuzalwa okungenayo i-hormonal njengendlela yokuvimbela (idivaysi evimbela isidoda ukuba singene esibelethweni njengekhondomu noma i-diaphragm). Buza udokotela wakho ukuthi akusize ukhethe indlela yokulawula ukubeletha ezokusebenzela. Uma ungowesifazane, kuzodingeka usebenzise ukulawulwa kokuzalwa okungewona okwe-hormonal ngesikhathi sokwelashwa kwakho nezinyanga ezi-4 ngemuva komthamo wakho wokugcina. Uma ungowesilisa, wena nomlingani wakho wesifazane kufanele nisebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa futhi niqhubeke nokusebenzisa ukubeletha izinyanga ezintathu ngemuva komthamo wakho wokugcina. I-Brigatinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngesikhathi sokwelashwa kwakho nge-brigatinib futhi kuze kube yiviki elilodwa ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala emadodeni. Khuluma nodokotela wakho ngezingozi zokuthatha i-brigatinib.

Gwema ukudla isithelo samagilebhisi nokuphuza ijusi lamagilebhisi ngenkathi uthatha i-brigatinib.

Yeqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa esivamile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

Uma uphuthelwa ukuthatha i-brigatinib izinsuku eziyi-14 noma ngaphezulu, khuluma nodokotela wakho ngaphambi kokuqala ukuyithatha futhi. Kuzodingeka uqale kabusha ukuyithatha ngomthamo ophansi.

I-Brigatinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• isifo sohudo
• ukuhlanza
• ukuqunjelwa
• ukukhathala
• ukuqubuka
• ikhanda
• ukuba ndikindiki, ubuhlungu, ukudlikizela, noma umuzwa ovuthayo ezinyaweni noma ezandleni
• ubuhlungu emuva noma ngokuhlanganyela
• ukulahlekelwa isifiso sokudla
• ubunzima bokulala noma ukulala

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuphefumula okuncane noma ukuphefumula kanzima
• ubuhlungu besifuba
• ukukhwehlela noma ungenawo amafinyila
• imfiva
• ikhanda, isiyezi, ikhanda elikhanyayo, noma ukuzizwa uphela amandla
• ukufiphala noma ukubona kabili
• ebona ukukhanya kokukhanya
• ukukhanya kulimaza amehlo akho
• ukubona '' ama-floaters '' noma amachashazi amancane
• ukoma ngokweqile, ukuchama njalo, ukulamba ngokweqile, ukungaboni kahle, noma ubuthakathaka
• ubuhlungu besisu obungasakazeka emhlane noma buba bibi ngokudla; ukuncipha komzimba; noma isicanucanu
• ukushaya kwenhliziyo okuhamba kancane noma okungajwayelekile
• ubuhlungu bemisipha, ukudumba, ubumnene, noma ubuthakathaka

I-Brigatinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzoku-oda ukuhlolwa kwelebhu ngaphambi kokuba uqale ukwelashwa kwakho ukuze ubone ukuthi umdlavuza wakho ungelashwa nge-brigatinib. Udokotela wakho naye uzo-oda izivivinyo ezithile zelebhu futhi ahlole umfutho wegazi lakho ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-brigatinib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Alunbrig^®