Safinamide

-Delile

• Ngaphambi kokuthatha i-safinamide,
• ISafinamide ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

ISafinamide isetshenziswa kanye nenhlanganisela ye-levodopa ne-carbidopa (iDuopa, iRytary, iSinemet, nezinye) ukwelapha iziqephu '' zokucisha '' (izikhathi zobunzima bokuhamba, ukuhamba nokukhuluma okungenzeka njengoba umuthi uphela noma ungahleliwe) ku abantu abanesifo sikaParkinson's (PD; ukuphazamiseka kwesistimu yezinzwa okubangela ubunzima ngokunyakaza, ukulawula imisipha, nokulinganisela). ISafinamide iseqenjini lemithi ebizwa nge-monoamine oxidase type B (MAO-B) inhibitors. Isebenza ngokwandisa inani le-dopamine (into yemvelo edingekayo ukulawula ukunyakaza) ebuchosheni.

ISafinamide iza njengethebhulethi ukuyiphuza ngomlomo. Imvamisa kuthathwa noma ngaphandle kokudla kanye ngosuku. Thatha i-safinamide ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-safinamide ngendlela eqondiswe ngayo. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Udokotela wakho kungenzeka akuqale ngomthamo ophansi we-safinamide futhi angakhuphula umthamo wakho kanye ngemuva kokungenani amasonto ama-2 okwelashwa.

Ungayeki ukuthatha i-safinamide ngaphandle kokukhuluma nodokotela wakho. Udokotela wakho mhlawumbe uzokwehlisa umthamo wakho ngaphambi kokuma. Uma ngokungazelelwe uyeka ukuthatha i-safinamide, ungahlangabezana nezimpawu zokuhoxa ezifana nomkhuhlane; ukuqina kwemisipha; ukudideka; noma ushintsho olwazini. Tshela udokotela wakho uma uhlangabezana nalezi zimpawu lapho umthamo wakho we-safinamide wehla.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-safinamide,

• Tshela udokotela kanye nosokhemisi wakho uma une-aleji ku-safinamide (ukuvuvukala komlomo noma kolimi, ukuphefumula okuncane), noma imuphi omunye umuthi, noma iziphi izithako ezisemaphilisi e-safinamide. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• utshele udokotela wakho uma uthatha noma yikuphi kokulandelayo: ama-amphetamine (ama-stimulants, ’uppers’) njenge-amphetamine (Adderall, Adzenys, Dyanavel XR, e-Adderall), dextroamphetamine (Dexedrine, e-Adderall), ne-methamphetamine (Desoxyn); imishanguzo ethile efana ne-amitriptyline (Elavil), amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Tofranil), mirtazapine (Remeron) ne-trazodone; buspirone; i-cyclobenzaprine (Amrix); i-methylphenidate (Aptensio, Metadate, Ritalin, abanye); ama-opioid afana ne-meperidine (Demerol), i-methadone (i-Dolophine, i-Methadose), i-propoxyphene (ayisatholakali e-U.S.; I-Darvon), noma i-tramadol (i-Conzip, i-Ultram, ku-Ultracet); i-serotonin ne-norepinephrine reuptake inhibitors (SSNRIs) ekhethiwe njenge-duloxetine (Cymbalta) ne-venlafaxine (Effexor); ne-wort yaseSt. Phinda utshele udokotela wakho uma uthatha i-MAO inhibitor efana ne-isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), noma i-tranylcypromine (iParnate) noma uyekile ukuthatha kubo emasontweni amabili edlule. Udokotela wakho uzokutshela ukuthi akufanele uthathe i-safinamide kanye neminye yale mithi. Uma uyeka ukuthatha i-safinamide, kufanele ulinde okungenani izinsuku eziyi-14 ngaphambi kokuba uqale ukuthatha noma iyiphi yale mithi. Futhi, ungathathi i-dextromethorphan (eRobitussin DM; etholakala kokukhwehlela okungabhaliswanga nemikhiqizo ebandayo) kanye ne-safinamide.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: imishanguzo yokuthambisa imishanguzo efana ne-clozapine (Clozaril, Fazaclo, Versacloz) ne-olanzapine (Zyprexa); i-benzodiazepines efana ne-alprazolam (Xanax), i-diazepam (i-Diastat, i-Valium), i-lorazepam (i-Ativan), i-temazepam (i-Restoril), ne-triazolam (i-Halcion); imithi yemikhuhlane kanye ne-allergies (ama-decongestants) kufaka phakathi leyo efakwe esweni noma ekhaleni; imatinib (Gleevec); i-irinotecan (Camptosar, Onivyde); i-isoniazid (iLaniazid, eRifamate, eRifater); i-lapatinib (iTykerb); i-methotrexate (i-Otrexup, i-Rasuvo); i-metoclopramide (Reglan); mitoxantrone; i-rosuvastatin (iCrestor); i-serotonin reuptake inhibitors ekhethiwe efana ne-citalopram (Celexa), i-escitalopram (Lexapro), i-fluoxetine (i-Prozac, i-Sarafem, i-Symbyax, abanye), i-fluvoxamine (i-Luvox), i-paroxetine (i-Brisdelle, i-Paxil, i-Pexeva), ne-sertraline (i-Zoloft); i-sulfasalazine (i-Azulfidine); ne-topotecan (i-Hycamtin). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• tshela udokotela wakho uma unesifo sesibindi. Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-safinamide.
• Tshela udokotela wakho uma uke waba nokugula kwengqondo okufana ne-schizophrenia (ukugula kwengqondo okubangela ukucabanga okuphazamisekile, ukulahlekelwa intshisekelo empilweni, nemizwelo enamandla noma engajwayelekile), i-bipolar disorder (imizwa eguquka isuke ekucindezelekeni iye ekuthokozeni okungavamile) , noma i-psychosis; noma uma unengcindezi ephezulu yegazi noma ephansi; i-dyskinesia (ukunyakaza okungavamile); noma izinkinga zokulala. Phinda utshele udokotela wakho uma wena noma ilunga lomndeni ninenkinga nge-retina yamehlo akho noma i-albinism (isimo esizuzwe njengefa esidala ukungabi bikho kwesikhumba, izinwele namehlo).
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uma ukhulelwa ngenkathi uthatha i-safinamide, shayela udokotela wakho.
• tshela udokotela wakho uma uncelisa noma uhlela ukuncelisa.
• kufanele wazi ukuthi i-safinamide ingakwenza ukozele noma ikubangele ukuthi ulale ngokuzumayo phakathi nemisebenzi yakho ejwayelekile yansuku zonke. Ungahle ungazeli ukozela noma ube nezinye izimpawu zokuxwayisa ngaphambi kokuba ulale ngokuzumayo.Ungashayeli imoto, sebenzisa imishini, usebenze ezindaweni eziphakeme, noma uhlanganyele emisebenzini engaba yingozi ekuqaleni kokwelashwa kwakho uze wazi ukuthi umuthi ukuthinta kanjani. Uma ulala ngokungazelelwe ngenkathi wenza okuthile njengokubuka ithelevishini, ukukhuluma, ukudla, noma ukugibela emotweni, noma uma wozela kakhulu, ikakhulukazi ngesikhathi sasemini, shayela udokotela wakho ucingo. Ungashayeli, usebenze ezindaweni eziphakeme, noma usebenzise imishini uze ukhulume nodokotela wakho.
• khumbula ukuthi utshwala bungangezela ukozela okubangelwa yilomuthi. Ungaphuzi utshwala ngenkathi uthatha i-safinamide.
• kufanele wazi ukuthi abanye abantu abathathe imishanguzo efana ne-safinamide baba nezinkinga zokugembula noma ezinye izifiso ezinamandla noma isimilo ebesibaphoqa noma singavamile kubo, njengokukhuphuka kwezifiso zocansi noma isimilo. Shayela udokotela wakho uma unesifiso sokugembula okunzima ukusilawula, unezikhalazo ezinkulu, noma awukwazi ukulawula ukuziphatha kwakho. Tshela amalungu omndeni wakho ngale ngozi ukuze bakwazi ukubiza udokotela noma ngabe awuboni ukuthi ukugembula kwakho noma yiziphi ezinye izifiso ezinamandla noma ukuziphatha okungajwayelekile kube yinkinga.

Ungahle uzwe ukusabela okungathi sína uma udla ukudla okune-tyramine enkulu ngesikhathi sokwelashwa kwakho nge-safinamide. I-Tyramine itholakala ekudleni naseziphuzweni eziningi, kufaka phakathi inyama, izinkukhu, inhlanzi, noma ushizi oshunqisiwe, osugugile, ogcinwe ngendlela engafanele noma okonakele; izithelo ezithile, imifino, nobhontshisi; iziphuzo ezidakayo; nemikhiqizo yemvubelo ebilile. Udokotela wakho noma isazi sokudla uzokutshela ukuthi yikuphi ukudla okufanele ukugweme ngokuphelele, nokuthi yikuphi ukudla ongakudla ngamanani amancane. Uma udla ukudla okune-tyramine enkulu ngenkathi uthatha i-safinamide, xhumana nodokotela wakho.

Yeqa umthamo ophuthelwe uthathe umthamo wakho olandelayo ngesikhathi esijwayelekile ngosuku olulandelayo. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

ISafinamide ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ubunzima bokulala noma ukulala

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukunyuka komzimba noma ukunyakaza komzimba okuvame kakhulu ongakwazi ukukulawula
• umbono uyashintsha
• ukusangana (ukubona izinto noma ukuzwa amazwi angekho)
• izinkolelo eziyinkohliso (ukukholelwa izinto ezingesizo ezangempela)
• ukudinwa, ukubona izinto ezingekho kahle, ukushisa komzimba, ukujuluka, ukudideka, ukushaya kwenhliziyo okusheshayo, ukuqhaqhazela, ukuqina kwemisipha okunzima noma ukudikiza, ukulahlekelwa ukuhlangana, isicanucanu, ukuhlanza noma isifo sohudo

ISafinamide ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Xadago^®